sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Veillonella
crohn's disease
Veillonella appears to be a strong and relatively human-grounded signal in crohn's disease.
Veillonella shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
veillonella
Credibility score
90
Human translation
4/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 90Human translation 4/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
33 papersPrediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.
2017Lancet (London, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis.
2017World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Cross sectional evaluation of the gut-microbiome metabolome axis in an Italian cohort of IBD patients.
2017Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut mucosal-associated microbiota better discloses inflammatory bowel disease differential patterns than faecal microbiota.
2019Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of the Salivary Microbiome During Different Phases of Crohn's Disease.
2020Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamic Alteration of the Gut Microbiota Associated with Obesity and Intestinal Inflammation in Ovariectomy C57BL/6 Mice.
2022International journal of endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary inflammatory potential mediated gut microbiota and metabolite alterations in Crohn's disease: A fire-new perspective.
2022Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Oral Microbiome in Treatment-Naïve Paediatric IBD Patients Exhibits Dysbiosis Related to Disease Severity that Resolves Following Therapy.
2023Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
2023International microbiology : the official journal of the Spanish Society for Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Metagenomic Composition and Effects of Fecal-Microbe-Derived Extracellular Vesicles on Intestinal Permeability Depend on the Patient's Disease.
2023International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Pre-Diagnostic Saliva Microbiota of School-Aged Children Who Developed Type 1 Diabetes or Inflammatory Bowel Diseases.
2023International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Signatures Are Associated With Psychopathological Profiles in Patients With Ulcerative Colitis: Results From an Italian Tertiary IBD Center.
2023Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota analyses of inflammatory bowel diseases from a representative Saudi population.
2023BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Pro-Inflammatory Diet Is Correlated with High Veillonella rogosae, Gut Inflammation and Clinical Relapse of Inflammatory Bowel Disease.
2023Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Serial Fecal Microbiota Infusions via Colonoscopy for Active Ulcerative Colitis: A Feasibility, Safety, and Translational Monocentric Italian Study.
2023Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Deciphering salivary microbiome signature in Crohn's disease patients with different factors contributing to dysbiosis.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exclusive Enteral Nutrition Mediates Beneficial Gut Microbiome Enrichment in Acute Severe Colitis.
2024Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparative diet-gut microbiome analysis in Crohn's disease and Hidradenitis suppurativa.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis and Associated Stool Features Improve Prediction of Response to Biological Therapy in Inflammatory Bowel Disease.
2024Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Detecting and quantifying Veillonella by real-time quantitative PCR and droplet digital PCR.
2024Applied microbiology and biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients.
2024Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inflammatory bowel disease associated with primary sclerosing cholangitis is associated with an altered gut microbiome and bile acid profile.
2024Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of neural alterations in patients with Crohn's disease with a novel multiparametric brain MRI-based radiomics model.
2024Insights into imaging
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the salivary microbiome of adults with inflammatory bowel disease.
2025Journal of oral microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[1]The human gut microbiota in IBD, characterizing hubs, the core microbiota and terminal nodes: a network-based approach.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and metabolome interactions in Crohn's disease: mechanistic insights into exclusive enteral nutrition-induced remission.
2025Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics integration reveals functional signatures of gut microbiome in atherosclerosis.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
First insights into microbial changes within an Inflammatory Bowel Disease Family Cohort study.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Genetic architecture of primary sclerosing cholangitis: shared pathways with inflammatory bowel disease and gut-liver axis mediation.
2026International journal of surgery (London, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Network and machine learning integration reveals gut microbiome biomarkers in pediatric IBD.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
11 papersNLRX1 Modulates Immunometabolic Mechanisms Controlling the Host-Gut Microbiota Interactions during Inflammatory Bowel Disease.
2018Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Influence of cigarette smoking on the human duodenal mucosa-associated microbiota.
2018Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium Veillonella parvula in the intestine.
2022Nature microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
SAELGMDA: Identifying human microbe-disease associations based on sparse autoencoder and LightGBM.
2023Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Regulation of gut microbiota and alleviation of DSS-induced colitis by vitexin.
2023European journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Isolation, identification, and significance of salivary Veillonella spp., Prevotella spp., and Prevotella salivae in patients with inflammatory bowel disease.
2023Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Baseline colitogenicity and acute perturbations of gut microbiota in immunotherapy-related colitis.
2025The Journal of experimental medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Veillonella intestinal colonization promotes C. difficile infection in Crohn's disease.
2025Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersDifferences in Gut Microbiota in Patients With vs Without Inflammatory Bowel Diseases: A Systematic Review.
2020Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
A study on the causal relationship between the gut microbiome and herpes zoster using Mendelian randomization.
2024Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis of Gut Microbiota in Microscopic Colitis: Diagnostic and Therapeutic Implications.
2025Diagnostics (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Anaerobic gut bacteria and their potential role in the initiation, exacerbation, and development of human colorectal cancer: a narrative review.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.