sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Veillonella
colorectal cancer
Veillonella is an interesting but still moderate-confidence signal in colorectal cancer.
Veillonella shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.
veillonella
Credibility score
55
Human translation
3/5
Reproducibility
4/5
Novelty
3/5
Actionability
5/5
Credibility 55Human translation 3/5Reproducibility 4/5Novelty 3/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
20 papersComparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses.
2016Oncology reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Shifts in the Fecal Microbiota Associated with Adenomatous Polyps.
2017Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Microbiota in Patients Treated by Surgery or Chemotherapy by 16S rRNA Sequencing Reveals Potential Biomarkers for Colorectal Cancer Therapy.
2018Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interactions between the gut microbiome and host gene regulation in cystic fibrosis.
2020Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of postoperative adjuvant chemotherapy and palliative chemotherapy on the gut microbiome in colorectal cancer.
2020Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Randomised clinical study: oral aspirin 325 mg daily vs placebo alters gut microbial composition and bacterial taxa associated with colorectal cancer risk.
2020Alimentary pharmacology & therapeutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the salivary and fecal microbiome in patients with primary sclerosing cholangitis.
2021Hepatology international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota.
2020World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiome Composition in Lynch Syndrome With and Without History of Colorectal Neoplasia and Non-Lynch Controls.
2024Journal of gastrointestinal cancer
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Veillonella Bacteremia in a Patient With Metastatic Colorectal Carcinoma.
2023Cureus
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Berberine might block colorectal carcinogenesis by inhibiting the regulation of B-cell function by Veillonella parvula.
2023Chinese medical journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal Microbiome in Patients with Early Bowel Polyps: Inferences from Short-Read and Long-Read 16S rRNA Sequencing.
2023Cancers
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The relationship between gastric microbiome features and responses to neoadjuvant chemotherapy in gastric cancer.
2024Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The effect of daily usage of Listerine Cool Mint mouthwash on the oropharyngeal microbiome: a substudy of the PReGo trial.
2024Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome related to metabolic diseases after moderate-to-vigorous intensity exercise.
2024Journal of exercise science and fitness
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-cohort analysis reveals colorectal cancer tumor location-associated fecal microbiota and their clinical impact.
2025Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial profiling of colorectal cancer biopsies: a culture-based study in Indian patients.
2025Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Stabilization of human RNA and DNA in stool samples at room temperature.
2025BioTechniques
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Signatures of Colorectal Cancer in the Jordanian Population: A Regional Case-Control Analysis Using 16S rRNA Profiling.
2025Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal bacterial flora in patients with colon cancer and control subjects.
1981Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. 1. Abt. Originale A, Medizinische Mikrobiologie, Infektionskrankheiten und Parasitologie = International journal of microbiology and hygiene. A, Medical microbiology, infectious...
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
12 papersAlterations in intestinal microbiota of colorectal cancer patients receiving radical surgery combined with adjuvant CapeOx therapy.
2019Science China. Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A metagenomic assessment of gut microbiota in Indian colon cancer patients.
2022Journal of cancer research and therapeutics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Changes of gut microbiota in colorectal cancer patients with Pentatrichomonas hominis infection.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Inflammation-associated nitrate facilitates ectopic colonization of oral bacterium Veillonella parvula in the intestine.
2022Nature microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered gut microbiome composition by appendectomy contributes to colorectal cancer.
2023Oncogene
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Irinotecan-gut microbiota interactions and the capability of probiotics to mitigate Irinotecan-associated toxicity.
2023BMC microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
SAELGMDA: Identifying human microbe-disease associations based on sparse autoencoder and LightGBM.
2023Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Biomimetic piezoelectric nanomaterial-modified oral microrobots for targeted catalytic and immunotherapy of colorectal cancer.
2024Science advances
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Effects of Aspirin Intervention on Inflammation-Associated Lingual Bacteria: A Pilot Study from a Randomized Clinical Trial.
2024Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota, immune cell, colorectal cancer association mediators: a Mendelian randomization study.
2025BMC cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Exploring the genetic determinants of the oral microbiome's role in gastrointestinal cancer risk: Mendelian randomization and genetic correlation analysis in an East Asian population.
2025Discover oncology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersAnaerobic gut bacteria and their potential role in the initiation, exacerbation, and development of human colorectal cancer: a narrative review.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.