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supportedtopmoderate inflation risk

Tryptophan metabolism

atopic dermatitis

Tryptophan metabolism is an interesting but still moderate-confidence signal in atopic dermatitis.

Tryptophan metabolism shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.

tryptophan_metabolism
Credibility score
54
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
3/5
Credibility 54Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 3/5
Why this scores the way it does
  • moderate central evidence base
  • dense review literature
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

14 papers
Non-invasive skin biomarkers quantification of psoriasis and atopic dermatitis: cytokines, antioxidants and psoriatic skin auto-fluorescence.
2012
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Importance of tryptophan nitration of carbonic anhydrase III for the morbidity of atopic dermatitis.
2014
Free radical biology & medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exaggerated IDO1 expression and activity in Langerhans cells from patients with atopic dermatitis upon viral stimulation: a potential predictive biomarker for high risk of Eczema herpeticum.
2015
Allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases.
2016
The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbe-host interplay in atopic dermatitis and psoriasis.
2019
Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolomics Distinguishes DOCK8 Deficiency from Atopic Dermatitis: Towards a Biomarker Discovery.
2019
Metabolites
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in Gut Microbiota of Patients with Atopic Dermatitis During Balneotherapy.
2022
Clinical, cosmetic and investigational dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bifidobacterium longum mediated tryptophan metabolism to improve atopic dermatitis via the gut-skin axis.
2022
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Indole-3-Lactic Acid, a Metabolite of Tryptophan, on IL-4 and IL-13-Induced Human Skin-Equivalent Atopic Dermatitis Models.
2022
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comprehensive Genomic Characterization of Staphylococcus aureus Isolated from Atopic Dermatitis Patients in Japan: Correlations with Disease Severity, Eruption Type, and Anatomical Site.
2023
Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Efficacy and associated neurotransmitters of digital cognitive behavior therapy for atopic dermatitis: A comparative effectiveness research.
2025
Asian Pacific journal of allergy and immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dupilumab therapy improves gut microbiome dysbiosis and tryptophan metabolism in Chinese patients with atopic dermatitis.
2024
International immunopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated plasma metabolomic and cytokine analysis reveals a distinct immunometabolic signature in atopic dermatitis.
2024
Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study.
2025
The World Allergy Organization journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Preclinical supporting evidence

12 papers
FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses.
2002
Journal of immunology (Baltimore, Md. : 1950)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis.
2004
Journal of dermatological science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor.
2019
The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of the dipeptide L-glutamic acid-L-tryptophan on dermatitis in mice and human keratinocytes.
2022
Heliyon
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Identification of Malassezia species isolated from some Malassezia associated skin diseases.
2022
Journal de mycologie medicale
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Limosilactobacillus reuteri Attenuates Atopic Dermatitis via Changes in Gut Bacteria and Indole Derivatives from Tryptophan Metabolism.
2022
International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated transcriptomic and metabolomic analyses of DNCB-induced atopic dermatitis in mice.
2023
Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Aromatic oil from lavender as an atopic dermatitis suppressant.
2024
PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin microbe-dependent TSLP-ILC2 priming axis in early life is co-opted in allergic inflammation.
2024
Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Therapeutic Mechanism of Kynurenine, a Metabolite of Probiotics, on Atopic Dermatitis in Mice.
2025
Foods (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Phytic Acid Improves the Skin Barrier Function in Murine Models of Atopic Dermatitis Through Skin Microbiota-Derived Indole-3-Propionic Acid.
2025
Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Commensal Staphylococci attenuate Staphylococcus aureus skin colonization and inflammation via AHR-dependent signaling.
2025
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

17 papers
[Skin diseases with photosensitivity].
1992
La Revue du praticien
Relevant review or meta-analysis for the signal-disease area.
Tryptophan Metabolism in Allergic Disorders.
2016
International archives of allergy and immunology
Relevant review or meta-analysis for the signal-disease area.
Aryl Hydrocarbon Receptor in Atopic Dermatitis and Psoriasis.
2019
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
The Role of the Microbiome and Microbiome-Derived Metabolites in Atopic Dermatitis and Non-Histaminergic Itch.
2020
American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
The Metabolomics of Childhood Atopic Diseases: A Comprehensive Pathway-Specific Review.
2020
Metabolites
Relevant review or meta-analysis for the signal-disease area.
A New Insight into the Potential Role of Tryptophan-Derived AhR Ligands in Skin Physiological and Pathological Processes.
2021
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Bacterial Metabolites: A Link between Gut Microbiota and Dermatological Diseases.
2023
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Melatonin in Dermatologic Allergic Diseases and Other Skin Conditions: Current Trends and Reports.
2023
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Bacterial Metabolites and Inflammatory Skin Diseases.
2023
Metabolites
Relevant review or meta-analysis for the signal-disease area.
Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications.
2023
Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis.
2023
Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Unraveling the gut-skin axis in atopic dermatitis: exploiting insights for therapeutic strategies.
2024
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
The Aryl Hydrocarbon Receptor (AHR): Peacekeeper of the Skin.
2025
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Skin-associated commensal microorganisms and their metabolites.
2025
Journal of applied microbiology
Relevant review or meta-analysis for the signal-disease area.
The brain-gut-skin axis in inflammatory and disfiguring skin diseases: mechanistic insights, clinical correlations, and therapeutic strategies.
2026
Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Gut Dysbiosis and the Molecular Landscape of the Gut-Skin Axis: Comparative Insights and Therapeutic Implications for Atopic Dermatitis and Psoriasis.
2026
Cells
Relevant review or meta-analysis for the signal-disease area.
Atopic dermatitis: Multi-omics insights into microbiota-driven modulation of the gut-skin axis.
2026
Microbial pathogenesis
Relevant review or meta-analysis for the signal-disease area.