sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Subdoligranulum
obesity
Subdoligranulum is an interesting but still moderate-confidence signal in obesity.
Subdoligranulum shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
subdoligranulum
Credibility score
55
Human translation
4/5
Reproducibility
4/5
Novelty
3/5
Actionability
3/5
Credibility 55Human translation 4/5Reproducibility 4/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
20 papersLong-Term Vegan Meditation Improved Human Gut Microbiota.
2020Evidence-based complementary and alternative medicine : eCAM
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Anti-obesity effects of Chenpi: an artificial gastrointestinal system study.
2022Microbial biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and BMI throughout childhood: the role of firmicutes, bacteroidetes, and short-chain fatty acid producers.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in the gut microbiome composition of Korean children and adult samples based on different DNA isolation kits.
2022PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Effect of Short-Term Consumption of Lactic Acid Bacteria on the Gut Microbiota in Obese People.
2022Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific gut bacterial and fungal microbiota pattern in the first half of pregnancy is linked to the development of gestational diabetes mellitus in the cohort including obese women.
2022Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Facilitating a high-quality dietary pattern induces shared microbial responses linking diet quality, blood pressure, and microbial sterol metabolism in caregiver-child dyads.
2022Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The fecal microbiotas of women of Pacific and New Zealand European ethnicities are characterized by distinctive enterotypes that reflect dietary intakes and fecal water content.
2023Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of summer acupoint application treatment (SAAT) on gut microbiota in healthy Asian adults: A randomized controlled trial.
2023Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Consumption of yacon flour and energy-restricted diet increased the relative abundance of intestinal bacteria in obese adults.
2023Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Potassium sodium hydrogen citrate intervention on gut microbiota and clinical features in uric acid stone patients.
2024Applied microbiology and biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota in Patients with Non-Alcoholic Fatty Liver Disease without Type 2 Diabetes: Stratified by Body Mass Index.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhancing gut microbiota and microbial function with inulin supplementation in children with obesity.
2024International journal of obesity (2005)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Examination of sex-specific interactions between gut microbiota and host metabolism after 12-week combined polyphenol supplementation in individuals with overweight or obesity.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Influence of gender, age, and body mass index on the gut microbiota of individuals from South China.
2024Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Regular Consumption of Black Tea Kombucha Modulates the Gut Microbiota in Individuals with and without Obesity.
2025The Journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Time-Restricted Eating (Early and Late) Combined with Energy Restriction vs. Energy Restriction Alone on the Gut Microbiome in Adults with Obesity.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.
2025Journal of microbiology and biotechnology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Leptin receptor gene influences pig gut microbiota both through feed intake and independently.
2025Animal microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
8 papersThe anti-obesity effect of Ephedra sinica through modulation of gut microbiota in obese Korean women.
2014Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of the Brown Seaweed Laminaria japonica Supplementation on Serum Concentrations of IgG, Triglycerides, and Cholesterol, and Intestinal Microbiota Composition in Rats.
2018Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Osteoprotective effect of green tea polyphenols and annatto-extracted tocotrienol in obese mice is associated with enhanced microbiome vitamin K2 biosynthetic pathways.
2020The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
From correlation to causality: the case of Subdoligranulum.
2020Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Geranylgeraniol and Green Tea Polyphenols Mitigate Negative Effects of a High-Fat Diet on Skeletal Muscle and the Gut Microbiome in Male C57BL/6J Mice.
2022Metabolites
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High barley intake in non-obese individuals is associated with high natto consumption and abundance of butyrate-producing bacteria in the gut: a cross-sectional study.
2024Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Optimal Algorithm for Gut Microbiota Differentiation: A Pilot Study of Adolescents with Different Body Weights.
2025Frontiers in bioscience (Scholar edition)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Dysbiosis and Toxic Metabolite Pathways Linked to Childhood Obesity in Eastern China.
2025Toxics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
3 papersCharacteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota profiles in two New Zealand cohorts with overweight and prediabetes: a Tū Ora/PREVIEW comparative study.
2023Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut microbial signatures associated with the Indian lean MASLD phenotype.
2025Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.