Highlighting new phylogenetic specificities of Crohn's disease microbiota.
2011Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
supportedmidmoderate inflation risk
Subdoligranulum
crohn's disease
Subdoligranulum is an interesting but still moderate-confidence signal in crohn's disease.
Subdoligranulum shows a moderate evidence base in crohn's disease, with multiple central papers and additional supporting literature.
subdoligranulum
Credibility score
35
Human translation
4/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 35Human translation 4/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
Main caveats
- directionality and confounding still require curated review
Primary central evidence
13 papersCampylobacter concisus and exotoxin 9 levels in paediatric patients with Crohn's disease and their association with the intestinal microbiota.
2014Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Longitudinal Changes in Fecal Calprotectin Levels Among Pregnant Women With and Without Inflammatory Bowel Disease and Their Babies.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota profile in patients with inflammatory bowel disease in Taiwan.
2021Journal of the Chinese Medical Association : JCMA
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between ustekinumab therapy and changes in specific anti-microbial response, serum biomarkers, and microbiota composition in patients with IBD: A pilot study.
2022PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosa-Associated Oscillospira sp. Is Related to Intestinal Stricture and Post-Operative Disease Course in Crohn's Disease.
2023Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial butyrate capacity is reduced in inflamed mucosa in patients with ulcerative colitis.
2024Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn's disease: a prospective trial.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[1]The human gut microbiota in IBD, characterizing hubs, the core microbiota and terminal nodes: a network-based approach.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
New potential biomarkers of ulcerative colitis and disease course - integrated metagenomic and metabolomic analysis among Polish patients.
2025Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predicting Risk of Post-Treatment Relapse in Patients with Inflammatory Bowel Disease Based on Intestinal Microbiota.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota composition and function are associated with anxiety and depression in patients with inflammatory bowel disease.
2025PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
4 papersVitamin D administration leads to a shift of the intestinal bacterial composition in Crohn's disease patients, but not in healthy controls.
2018Journal of digestive diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Combined analysis of metagenomic data revealed consistent changes of gut microbiome structure and function in inflammatory bowel disease.
2021Journal of applied microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Heat-Killed Bifidobacterium bifidum B1628 May Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, and the Anti-Inflammatory Effect Is Associated with Gut Microbiota Modulation.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersCharacteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.