review_heavy
Review literature is very dense relative to primary central evidence.
fulltoplow inflation risk
Streptococcus
inflammatory bowel disease
Streptococcus looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Streptococcus shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
streptococcus
Credibility score
68
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
4/5
Credibility 68Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
18 papersInflammatory bowel disease and Streptococcus bovis.
2006Digestive diseases and sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Human inflammatory bowel disease does not associate with Lawsonia intracellularis infection.
2006BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers.
2014DNA research : an international journal for rapid publication of reports on genes and genomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Glucocorticoid and dietary effects on mucosal microbiota in canine inflammatory bowel disease.
2019PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease.
2020Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Detection of Streptococcus gallolyticus in colorectal cancer and inflammatory bowel disease patients compared to control group in southwest of Iran.
2020Molecular biology reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis.
2022Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinctive gut microbiomes of ankylosing spondylitis and inflammatory bowel disease patients suggest differing roles in pathogenesis and correlate with disease activity.
2022Arthritis research & therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative real-time PCR analysis of bacterial biomarkers enable fast and accurate monitoring in inflammatory bowel disease.
2022PeerJ
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients.
2023EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Bidirectional Effects of Periodontal Disease and Oral Dysbiosis on Gut Inflammation in Inflammatory Bowel Disease.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the salivary microbiome of adults with inflammatory bowel disease.
2025Journal of oral microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Combined metabolomic and metagenomic analysis reveals inflammatory bowel disease diversity in pediatric and adult patients.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial L-form isolation from inflammatory bowel disease patients.
1983Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersNew Pneumococcal Vaccines for Prevention of Invasive Pneumococcal Disease in Adult Patients With Inflammatory Bowel Disease.
2023Inflammatory bowel diseases
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
11 papersSubgingival microflora in inflammatory bowel disease patients with untreated periodontitis.
2013European journal of gastroenterology & hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Identification of shared and disease-specific host gene-microbiome associations across human diseases using multi-omic integration.
2022Nature microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota.
2023Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome signatures of Yorkshire Terrier enteropathy during disease and remission.
2023Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Composition of the colon microbiota in the individuals with inflammatory bowel disease and colon cancer.
2024Folia microbiologica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Rapamycin extenuates experimental colitis by modulating the gut microbiota.
2023Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A DNA Nanopatch-Bacteriophage System Targeting Streptococcus Gallolyticus for Inflammatory Bowel Disease Treatment and Colorectal Cancer Prevention.
2025Advanced materials (Deerfield Beach, Fla.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel plant-derived compounds modulate gut microbiome dysbiosis in colitis mice: A potential therapeutic avenue for inflammatory bowel disease.
2026Microbiological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease.
2025Journal of periodontology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
21 papersPlasma and tissue kallikrein in arthritis and inflammatory bowel disease.
1999Immunopharmacology
Relevant review or meta-analysis for the signal-disease area.
Yogurt and gut function.
2004The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Surveillance of patients at increased risk of colon cancer: inflammatory bowel disease and other conditions.
2008Gastroenterology clinics of North America
Relevant review or meta-analysis for the signal-disease area.
Probiotics.
2009Indian journal of medical microbiology
Relevant review or meta-analysis for the signal-disease area.
The microbiota in inflammatory bowel disease in different age groups.
2009Digestive diseases (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Effects of immunosuppressants on immune response to vaccine in inflammatory bowel disease.
2015Chinese medical journal
Relevant review or meta-analysis for the signal-disease area.
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
2019Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Preventing Infections by Encapsulated Bacteria Through Vaccine Prophylaxis in Inflammatory Bowel Disease.
2020Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome in primary sclerosing cholangitis: A review.
2020World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
New Insights into the Role of Oral Microbiota Dysbiosis in the Pathogenesis of Inflammatory Bowel Disease.
2022Digestive diseases and sciences
Relevant review or meta-analysis for the signal-disease area.
Immune response to influenza and pneumococcal vaccines in adults with inflammatory bowel disease: A systematic review and meta-analysis of 1429 patients.
2022Vaccine
Relevant review or meta-analysis for the signal-disease area.
Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response.
2022Current microbiology
Relevant review or meta-analysis for the signal-disease area.
Insight into the Relationship between Oral Microbiota and the Inflammatory Bowel Disease.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
The microbiome and rheumatic heart disease: current knowledge and future perspectives.
2023Acta cardiologica
Relevant review or meta-analysis for the signal-disease area.
In Vivo Functional Properties of Dairy Bacteria.
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go?
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
The role of interleukin-36 in health and disease states.
2024Journal of the European Academy of Dermatology and Venereology : JEADV
Relevant review or meta-analysis for the signal-disease area.
Oral Anti-Inflammatory and Symbiotic Effects of Fermented Lingonberry Juice-Potential Benefits in IBD.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Roles of Streptococcus mutans in human health: beyond dental caries.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.