review_heavy
Review literature is very dense relative to primary central evidence.
fulltoplow inflation risk
Streptococcus
crohn's disease
Streptococcus looks like a credible signal in crohn's disease, though some caution is still warranted.
Streptococcus shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
streptococcus
Credibility score
61
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 61Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
16 papersA Distinct Gut Microbiota Exists Within Crohn's Disease-Related Perianal Fistulae.
2019The Journal of surgical research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel disease.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal Microbiome Profiles Polygenic Irritable Bowel Syndrome in Mestizo Individuals.
2020Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Antitumor Necrosis Factor-like Ligand 1A Therapy Targets Tissue Inflammation and Fibrosis Pathways and Reduces Gut Pathobionts in Ulcerative Colitis.
2022Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gastrointestinal microbiome and Helicobacter pylori: Eradicate, leave it as it is, or take a personalized benefit-risk approach?
2022World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Host-microbiota interaction-mediated resistance to inflammatory bowel disease in pigs.
2022Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrative multi-omics deciphers the spatial characteristics of host-gut microbiota interactions in Crohn's disease.
2023Cell reports. Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Deciphering salivary microbiome signature in Crohn's disease patients with different factors contributing to dysbiosis.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reverse-engineered exclusive enteral nutrition in pediatric Crohn's disease: A pilot trial.
2024Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients.
2024Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis.
2024Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the salivary microbiome of adults with inflammatory bowel disease.
2025Journal of oral microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Smoking affects gut immune system of patients with inflammatory bowel diseases by modulating metabolomic profiles and mucosal microbiota.
2025Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decoding IBD progression: a dynamic biomarker atlas for personalized disease stratification.
2025Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
10 papersNew-Onset of Crohn's Disease Is Associated with Antistreptolysin O Positive Titers.
2020Clinical and experimental gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Childhood Invasive Bacterial Disease in Kathmandu, Nepal (2005-2013).
2022The Pediatric infectious disease journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Identification of shared and disease-specific host gene-microbiome associations across human diseases using multi-omic integration.
2022Nature microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota.
2023Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome signatures of Yorkshire Terrier enteropathy during disease and remission.
2023Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Rapamycin extenuates experimental colitis by modulating the gut microbiota.
2023Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary whey protein protects against Crohn's disease by orchestrating cross-kingdom interaction between the gut phageome and bacteriome.
2025Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease.
2025Journal of periodontology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
21 papersYogurt and gut function.
2004The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Behcet's disease.
2004Clinical and experimental medicine
Relevant review or meta-analysis for the signal-disease area.
Probiotics.
2009Indian journal of medical microbiology
Relevant review or meta-analysis for the signal-disease area.
The microbiota in inflammatory bowel disease in different age groups.
2009Digestive diseases (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Mobile microbiome: oral bacteria in extra-oral infections and inflammation.
2013Journal of dental research
Relevant review or meta-analysis for the signal-disease area.
Psoriasis is not an autoimmune disease?
2015Experimental dermatology
Relevant review or meta-analysis for the signal-disease area.
Effects of immunosuppressants on immune response to vaccine in inflammatory bowel disease.
2015Chinese medical journal
Relevant review or meta-analysis for the signal-disease area.
Identification of universal gut microbial biomarkers of common human intestinal diseases by meta-analysis.
2017FEMS microbiology ecology
Relevant review or meta-analysis for the signal-disease area.
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
2019Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Mechanisms of microbial pathogenesis and the role of the skin microbiome in psoriasis: A review.
2019Clinics in dermatology
Relevant review or meta-analysis for the signal-disease area.
Preventing Infections by Encapsulated Bacteria Through Vaccine Prophylaxis in Inflammatory Bowel Disease.
2020Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Vaccine therapy for dysbiosis-related diseases.
2020World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
New Insights into the Role of Oral Microbiota Dysbiosis in the Pathogenesis of Inflammatory Bowel Disease.
2022Digestive diseases and sciences
Relevant review or meta-analysis for the signal-disease area.
Carcinogenic microbiota and its role in colorectal cancer development.
2022Seminars in cancer biology
Relevant review or meta-analysis for the signal-disease area.
Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response.
2022Current microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
The microbiome and rheumatic heart disease: current knowledge and future perspectives.
2023Acta cardiologica
Relevant review or meta-analysis for the signal-disease area.
The role of interleukin-36 in health and disease states.
2024Journal of the European Academy of Dermatology and Venereology : JEADV
Relevant review or meta-analysis for the signal-disease area.
Oral Anti-Inflammatory and Symbiotic Effects of Fermented Lingonberry Juice-Potential Benefits in IBD.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Roles of Streptococcus mutans in human health: beyond dental caries.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.