review_heavy
Review literature is very dense relative to primary central evidence.
supportedtopmoderate inflation risk
Streptococcus
colorectal cancer
Streptococcus is an interesting but still moderate-confidence signal in colorectal cancer.
Streptococcus shows a moderate evidence base in colorectal cancer, with multiple central papers and additional supporting literature.
streptococcus
Credibility score
56
Human translation
4/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 56Human translation 4/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
13 papersThe oral microbiota in colorectal cancer is distinctive and predictive.
2018Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Moderate alteration to gut microbiota brought by colorectal adenoma resection.
2019Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of human gut microbiome in young-onset colorectal cancer.
2021Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal Microbiota in Colorectal Adenoma-Carcinoma Sequence.
2022Frontiers in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlations between Intestinal Microbiota and Clinical Characteristics in Colorectal Adenoma/Carcinoma.
2022BioMed research international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prediction model of poorly differentiated colorectal cancer (CRC) based on gut bacteria.
2022BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Postoperative Probiotics Administration Attenuates Gastrointestinal Complications and Gut Microbiota Dysbiosis Caused by Chemotherapy in Colorectal Cancer Patients.
2023Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Streptococcus gallolyticus infection: A neglected marker for colorectal cancer?
2023Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The effect of daily usage of Listerine Cool Mint mouthwash on the oropharyngeal microbiome: a substudy of the PReGo trial.
2024Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbial subtypes and clinicopathological value for colorectal cancer.
2024Cancer medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-cohort analysis reveals colorectal cancer tumor location-associated fecal microbiota and their clinical impact.
2025Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Colorectal cancer-associated Streptococcus gallolyticus: a hidden diversity expose.
2025Journal of bacteriology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct microbiota composition and dendritic cell activation in the appendix microenvironment of ulcerative colitis patients.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
5 papersStreptococcus thermophilus Inhibits Colorectal Tumorigenesis Through Secreting β-Galactosidase.
2021Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A pathogenicity locus of Streptococcus gallolyticus subspecies gallolyticus.
2023Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bloodstream Infection and Colorectal Cancer Risk in Queensland Australia, 2000-2019.
2023The American journal of medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Aging characteristics of colorectal cancer based on gut microbiota.
2023Cancer medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Streptococcus gallolyticus supernatant induces M2 macrophage polarization and activates IL-17 F signaling in colorectal tumorigenesis.
2025Gut pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
26 papersProtective role of probiotics and prebiotics in colon cancer.
2001The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Yogurt and gut function.
2004The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Microbial and viral pathogens in colorectal cancer.
2011The Lancet. Oncology
Relevant review or meta-analysis for the signal-disease area.
Genomics, evolution, and molecular epidemiology of the Streptococcus bovis/Streptococcus equinus complex (SBSEC).
2015Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota imbalance and colorectal cancer.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Significance of Streptococcus gallolyticus subsp. gallolyticus Association With Colorectal Cancer.
2018Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
The gut microbiome and colorectal cancer: a review of bacterial pathogenesis.
2018Journal of gastrointestinal oncology
Relevant review or meta-analysis for the signal-disease area.
Microbiome Dysbiosis and Predominant Bacterial Species as Human Cancer Biomarkers.
2020Journal of gastrointestinal cancer
Relevant review or meta-analysis for the signal-disease area.
The Role of the Gut Microbiota in Colorectal Cancer Causation.
2019International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
The Intestinal Microbiota and Colorectal Cancer.
2020Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota-derived metabolites in CRC progression and causation.
2021Journal of cancer research and clinical oncology
Relevant review or meta-analysis for the signal-disease area.
Microbe-based management for colorectal cancer.
2021Chinese medical journal
Relevant review or meta-analysis for the signal-disease area.
Carcinogenic microbiota and its role in colorectal cancer development.
2022Seminars in cancer biology
Relevant review or meta-analysis for the signal-disease area.
Microbiome and colorectal carcinogenesis: Linked mechanisms and racial differences.
2022World journal of gastrointestinal oncology
Relevant review or meta-analysis for the signal-disease area.
Effect of gut microbiota in the colorectal cancer and potential target therapy.
2022Discover oncology
Relevant review or meta-analysis for the signal-disease area.
The Tissue-Associated Microbiota in Colorectal Cancer: A Systematic Review.
2022Cancers
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer.
2023Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Relevant review or meta-analysis for the signal-disease area.
Risk of colorectal cancer due to Streptococcus gallolyticus: a systematic review.
2023The Medical journal of Malaysia
Relevant review or meta-analysis for the signal-disease area.
Microbiota composition and its impact on DNA methylation in colorectal cancer.
2023Frontiers in genetics
Relevant review or meta-analysis for the signal-disease area.
Relationship between oral microbiota and colorectal cancer: A systematic review.
2024Journal of periodontal research
Relevant review or meta-analysis for the signal-disease area.
Microbiome landscapes of the bladder, intestine, and vagina in bladder cancer: a systematic review.
2025Discover oncology
Relevant review or meta-analysis for the signal-disease area.
Emerging New Treatments for Colon Cancer.
2025Current medicinal chemistry
Relevant review or meta-analysis for the signal-disease area.
Potential Pathogens Associated with Colorectal Cancer.
2025Current pharmaceutical biotechnology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and diet in colorectal cancer: Converging determinants of carcinogenesis.
2026Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Bacteriology of the gut and its clinical implications.
1974The Western journal of medicine
Relevant review or meta-analysis for the signal-disease area.