Skin Microbiome Compositional Changes in Atopic Dermatitis Accompany Dead Sea Climatotherapy.
2019Photochemistry and photobiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
supportedtopmoderate inflation risk
Streptococcus
atopic dermatitis
Streptococcus is an interesting but still moderate-confidence signal in atopic dermatitis.
Streptococcus shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
streptococcus
Credibility score
53
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 53Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- retrieval noise or disease-specificity issues may remain
Primary central evidence
12 papersSkin Microbiome Differences in Atopic Dermatitis and Healthy Controls in Egyptian Children and Adults, and Association with Serum Immunoglobulin E.
2019Omics : a journal of integrative biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the skin microbiome are associated with disease severity and treatment in the perioral zone of the skin of infants with atopic dermatitis.
2019European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Imbalance of Gut Streptococcus, Clostridium, and Akkermansia Determines the Natural Course of Atopic Dermatitis in Infant.
2020Allergy, asthma & immunology research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interactions Between IL-17 Variants and Streptococcus in the Gut Contribute to the Development of Atopic Dermatitis in Infancy.
2021Allergy, asthma & immunology research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China.
2021Journal of asthma and allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study.
2022Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Method for estimating disease risk from microbiome data using structural equation modeling.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gasdermin A Is Required for Epidermal Cornification during Skin Barrier Regeneration and in an Atopic Dermatitis-Like Model.
2023The Journal of investigative dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Co-occurrence network analysis reveals the alterations of the skin microbiome and metabolome in adults with mild to moderate atopic dermatitis.
2024mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Stratum corneum and microbial biomarkers precede and characterize childhood atopic dermatitis.
2024Journal of the European Academy of Dermatology and Venereology : JEADV
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Digital health framework for the predictive surveillance and diagnosis of atopic dermatitis.
2025Water research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersCharacterization of skin microbiota in patients with atopic dermatitis and in normal subjects using 16S rRNA gene-based comprehensive analysis.
2007Journal of medical microbiology
Human primary paper with plausible association relevance to the disease context.
Distinct Skin Microbiota Imbalance and Responses to Clinical Treatment in Children With Atopic Dermatitis.
2020Frontiers in cellular and infection microbiology
Human primary paper with plausible association relevance to the disease context.
Associations between early-life exposures and the infant skin microbiome.
2026The British journal of dermatology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
10 papersFrequency and clinical role of Staphylococcus aureus overinfection in atopic dermatitis in children.
2003Pediatric dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Streptococcus pyogenes upper respiratory infection and atopic conditions other than asthma: a retrospective cohort study.
2012Primary care respiratory journal : journal of the General Practice Airways Group
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis.
2012Genome research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiologic characterisation of bacterial infections in children with atopic dermatitis.
2022Southern African journal of infectious diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A cohort study of intrapartum group B streptococcus prophylaxis on atopic dermatitis in 2-year-old children.
2022BMC pediatrics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin microbiome and causal relationships in three dermatological diseases: Evidence from Mendelian randomization and Bayesian weighting.
2024Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Exploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Single-cell sequencing of human Langerhans cells identifies altered gene expression profiles in patients with atopic dermatitis.
2025ImmunoHorizons
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Environmental and skin-nasal microbiome variation in South African children with atopic dermatitis.
2025BMC microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin microbiome composition and function in the development of atopic diseases during infancy.
2025bioRxiv : the preprint server for biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
19 papersProbiotics.
2008American family physician
Relevant review or meta-analysis for the signal-disease area.
Bacterial skin colonization and infections in patients with atopic dermatitis.
2012Anais brasileiros de dermatologia
Relevant review or meta-analysis for the signal-disease area.
Staphylococcal and streptococcal superantigen exotoxins.
2013Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
Medical Complications of Tattoos: A Comprehensive Review.
2016Clinical reviews in allergy & immunology
Relevant review or meta-analysis for the signal-disease area.
An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis.
2018International journal of dermatology
Relevant review or meta-analysis for the signal-disease area.
Topical probiotics: the unknowns behind their rising popularity.
2019Dermatology online journal
Relevant review or meta-analysis for the signal-disease area.
Skin microbiota: Friend or foe in pediatric skin health and skin disease.
2019Pediatric dermatology
Relevant review or meta-analysis for the signal-disease area.
Frequency and Clinical Features Associated With Eczema Herpeticum in Hospitalized Children With Presumed Atopic Dermatitis Skin Infection.
2020The Pediatric infectious disease journal
Relevant review or meta-analysis for the signal-disease area.
The microbiome and its impact on food allergy and atopic dermatitis in children.
2020Postepy dermatologii i alergologii
Relevant review or meta-analysis for the signal-disease area.
The Translational Relevance of Human Circulating Memory Cutaneous Lymphocyte-Associated Antigen Positive T Cells in Inflammatory Skin Disorders.
2021Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Low Pneumococcal Vaccination among Patients with Psoriasis in Germany: Results from Vac-Pso.
2022Vaccines
Relevant review or meta-analysis for the signal-disease area.
In Vivo Functional Properties of Dairy Bacteria.
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.
The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update.
2023Frontiers in molecular biosciences
Relevant review or meta-analysis for the signal-disease area.
Secondary Bacterial Infections in Patients with Atopic Dermatitis or Other Common Dermatoses.
2024American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
The role of interleukin-36 in health and disease states.
2024Journal of the European Academy of Dermatology and Venereology : JEADV
Relevant review or meta-analysis for the signal-disease area.
The skin barrier and microbiome in infantile atopic dermatitis development: can skincare prevent onset?
2024International immunology
Relevant review or meta-analysis for the signal-disease area.
Vaccines in Dermatology-Present and Future: A Review.
2025Vaccines
Relevant review or meta-analysis for the signal-disease area.
Skin microbiota in atopic dermatitis: victim or executioner?
2025Clinical microbiology reviews
Relevant review or meta-analysis for the signal-disease area.
The Role of Skin Microbiota in Facial Dermatoses and Related Factors: A Narrative Review.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.