preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Staphylococcus
inflammatory bowel disease
Staphylococcus has meaningful literature visibility in inflammatory bowel disease, but the current evidence mix suggests a substantial risk of overclaiming.
Staphylococcus shows a moderate evidence base in inflammatory bowel disease, with multiple central papers and additional supporting literature.
staphylococcus
Credibility score
39
Human translation
1/5
Reproducibility
4/5
Novelty
3/5
Actionability
2/5
Credibility 39Human translation 1/5Reproducibility 4/5Novelty 3/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
7 papersStaphylococcus aureus in inflammatory bowel disease.
2001Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Defensin-immunology in inflammatory bowel disease.
2009Gastroenterologie clinique et biologique
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Coexistence of Clostridioides difficile and Staphylococcus aureus in gut of Iranian outpatients with underlying inflammatory bowel disease.
2020Anaerobe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Machine Learning Based Metagenomic Prediction of Inflammatory Bowel Disease.
2021Studies in health technology and informatics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Case report: Chronic granulomatous disease presenting with early-onset inflammatory bowel disease and normal oxidative burst testing.
2022Frontiers in pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Unraveling the blood microbiome: novel insights into inflammasome responses in Crohn's disease.
2024European journal of gastroenterology & hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adverse Events and Immune Response in Psoriasis Patients Receiving Interleukin-17 Inhibitors.
2025Acta dermato-venereologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersEscherichia coli RclA is a highly active hypothiocyanite reductase.
2022Proceedings of the National Academy of Sciences of the United States of America
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
22 papersMicrobial induction of inflammatory bowel disease associated gene TL1A (TNFSF15) in antigen presenting cells.
2009European journal of immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Serious infections in patients with inflammatory bowel disease receiving anti-tumor-necrosis-factor-alpha therapy: an Australian and New Zealand experience.
2010Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Subgingival microflora in inflammatory bowel disease patients with untreated periodontitis.
2013European journal of gastroenterology & hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human colonic mucus is a reservoir for antimicrobial peptides.
2013Journal of Crohn's & colitis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gene expression profiles of ileal inflammatory bowel disease correlate with disease phenotype and advance understanding of its immunopathogenesis.
2013Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Probiotic Lactobacillus rhamnosus inhibits the formation of neutrophil extracellular traps.
2014Journal of immunology (Baltimore, Md. : 1950)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation.
2017Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Saccharin Supplementation Inhibits Bacterial Growth and Reduces Experimental Colitis in Mice.
2020Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered Pattern of Immunoglobulin A-Targeted Microbiota in Inflammatory Bowel Disease After Fecal Transplantation.
2022Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Bifidobacterium bifidum TMC3115 Promotes Early Life Intestinal Microbiota Building to Alleviate Symptoms of Inflammatory Bowel Disease].
2022Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A novel gut inflammatory rat model by laparotomic injection of peptidoglycan from Staphylococcus aureus.
2022Archives of microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Chemoprofiling and antimicrobial activity of medicinal herbs used in the treatment of inflammatory bowel disease.
2023Cellular and molecular biology (Noisy-le-Grand, France)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
GLP-1 receptor agonists alleviate colonic inflammation by modulating intestinal microbiota and the function of group 3 innate lymphoid cells.
2024Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Proteolytic bacteria expansion during colitis amplifies inflammation through cleavage of the external domain of PAR2.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of antibiotic and disinfectant exposure on the mouse gut microbiome and immune function.
2024Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Therapeutic Potential of Cajanus cajan (L.) Millsp. Leaf Extract in Modulating Gut Microbiota and Immune Response for the Treatment of Inflammatory Bowel Disease.
2025Pharmaceuticals (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel plant-derived compounds modulate gut microbiome dysbiosis in colitis mice: A potential therapeutic avenue for inflammatory bowel disease.
2026Microbiological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ultra-processed foods sourced 7-ketositosterol aggravates colitis through gut dysbiosis induced-PDLIM3 activation.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pyoderma Gangrenosum Secondary to Melanotan.
2025Cureus
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Studies on isolated gut mucosal lymphocytes in inflammatory bowel disease. Detection of activated T cells and enhanced proliferation to Staphylococcus aureus and lipopolysaccharides.
1981Digestive diseases and sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Monocytes in inflammatory bowel disease: phagocytosis and intracellular killing.
1980Journal of clinical pathology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Interleukin 4 in inflammatory bowel disease and mucosal immune reactivity.
1996Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
16 papersUse of infliximab in pediatric patients with inflammatory bowel disease.
2001The Annals of pharmacotherapy
Relevant review or meta-analysis for the signal-disease area.
Neutrophil dysfunction in glycogen storage disease Ib: association with Crohn's-like colitis.
1991Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Prevalence and incidence of antimicrobial-resistant organisms among hospitalized inflammatory bowel disease patients.
2013The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
Relevant review or meta-analysis for the signal-disease area.
Hydradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Advances in atopic dermatitis in 2015.
2016The Journal of allergy and clinical immunology
Relevant review or meta-analysis for the signal-disease area.
Clinical Signs, Pathophysiology and Management of Cutaneous Side Effects of Anti-Tumor Necrosis Factor Agents.
2017American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
Bacterial Dysbiosis and Translocation in Psoriasis Vulgaris.
2019Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
[Chronic granulomatous disease. Update and review].
2019Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome in chronic rheumatic and inflammatory bowel diseases: Similarities and differences.
2019United European gastroenterology journal
Relevant review or meta-analysis for the signal-disease area.
The Microbiome in Hidradenitis Suppurativa: A Review.
2021Dermatology and therapy
Relevant review or meta-analysis for the signal-disease area.
Association of Gut Microbiota with Inflammatory Bowel Disease and COVID-19 Severity: A Possible Outcome of the Altered Immune Response.
2022Current microbiology
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Cross talk between bacterial and human gene networks enriched using ncRNAs in IBD disease.
2023Scientific reports
Relevant review or meta-analysis for the signal-disease area.
Haematopoietic Stem Cell Transplantation for Chronic Granulomatous Disease.
2023Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
2024Allergologie select
Relevant review or meta-analysis for the signal-disease area.
Hidradenitis Suppurativa from a Multi-Omic Scope.
2025Journal of cutaneous medicine and surgery
Relevant review or meta-analysis for the signal-disease area.