preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Staphylococcus
colorectal cancer
Staphylococcus has meaningful literature visibility in colorectal cancer, but the current evidence mix suggests a substantial risk of overclaiming.
Staphylococcus shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.
staphylococcus
Credibility score
78
Human translation
2/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 78Human translation 2/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
23 papersEndoscopic ultrasound-guided biopsy for the diagnosis of focal lesions of the spleen.
2003The American journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Significant changes in the intestinal environment after surgery in patients with colorectal cancer.
2013Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Chemical profiling and pharmaco-toxicological activity of Origanum sipyleum extracts: Exploring for novel sources for potential therapeutic agents.
2019Journal of food biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Engineering a Biodegradable Multifunctional Antibacterial Bioactive Nanosystem for Enhancing Tumor Photothermo-Chemotherapy and Bone Regeneration.
2020ACS nano
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrative Analysis of Fecal Metagenomics and Metabolomics in Colorectal Cancer.
2020Cancers
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Bloodstream infections in cancer patients].
2020Medicina
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Isolation of Novel Probiotic Lactobacillus and Enterococcus Strains From Human Salivary and Fecal Sources.
2020Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A teleost bactericidal permeability-increasing protein-derived peptide that possesses a broad antibacterial spectrum and inhibits bacterial infection as well as human colon cancer cells growth.
2021Developmental and comparative immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Insights from Bacterial 16S rRNA Gene into Bacterial Genera and Predicted Metabolic Pathways Associated with Stool Consistency in Rectal Cancer Patients: A Proof of Concept.
2023Biological research for nursing
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mechanical and oral antibiotics bowel preparation for elective rectal cancer surgery: A propensity score matching analysis using a nationwide inpatient database in Japan.
2023Annals of gastroenterological surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal Microbiota from Colorectal Cancer, Adenoma and Normal Epithelium Reveals the Imprint of Fusobacterium nucleatum in Cancerogenesis.
2023Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Antiproliferative Activity and Impact on Human Gut Microbiota of New O-Alkyl Derivatives of Naringenin and Their Oximes.
2023International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comprehensive analysis of distal-less homeobox family gene expression in colon cancer.
2023World journal of gastrointestinal oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome diversity in African American, European American, and Egyptian colorectal cancer patients.
2023Heliyon
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct intratumoral microbiome of young-onset and average-onset colorectal cancer.
2024EBioMedicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated analysis of gut microbiota and metabolomic profiling in colorectal cancer metastasis.
2024Environmental toxicology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prevalence and Outcomes of Sepsis in Patients With Colon Carcinoma: Organism-Specific Analysis.
2024Cureus
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal flora.
2025BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal bacterial biomarkers and blood biochemical indicators as potential key factors in the development of colorectal cancer.
2025mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Isolation, Screening, and Identification of Staphylococcus epidermidis with Effective Probiotic Attributes.
2025Current microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Nα-acetyl-L-lysine/Loxl2/H2O2 promotes intestinal tumor growth in Drosophila and cell proliferation in human colorectal cancer.
2025Cell reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immunotherapy of human colon cancer by antibody-targeted superantigens.
1995Cancer immunology, immunotherapy : CII
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Advanced colorectal cancer is associated with impaired interleukin 12 and enhanced interleukin 10 production.
1998Clinical cancer research : an official journal of the American Association for Cancer Research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersStaphylococcus cohnii septicaemia in a patient with colon cancer.
2003Journal of medical microbiology
Human primary paper with plausible association relevance to the disease context.
Relationship between the severity of diversion colitis and the composition of colonic bacteria: a prospective study.
2014Gut and liver
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
34 papersActivation of human peritoneal immune cells in early stages of gastric and colon cancer.
2007Surgery
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Synthesis and evaluation of (Z)-2,3-diphenylacrylonitrile analogs as anti-cancer and anti-microbial agents.
2013European journal of medicinal chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Whole genome sequence and comparative genomic analysis of multidrug-resistant Staphylococcus capitis subsp. urealyticus strain LNZR-1.
2014Gut pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anticancer metallohelices: nanomolar potency and high selectivity.
2016Chemical science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High Fat High Calories Diet (HFD) Increase Gut Susceptibility to Carcinogens by Altering the Gut Microbial Community.
2020Journal of Cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The High-Fat Diet Based on Extra-Virgin Olive Oil Causes Dysbiosis Linked to Colorectal Cancer Prevention.
2020Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bio fabrication of silver nanoparticles with antibacterial and cytotoxic abilities using lichens.
2020Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A type VII secretion system of Streptococcus gallolyticus subsp. gallolyticus contributes to gut colonization and the development of colon tumors.
2021PLoS pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
New iridium bis-terpyridine complexes: synthesis, characterization, antibiofilm and anticancer potentials.
2021Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integration of the Microbiome, Metabolome and Transcriptomics Data Identified Novel Metabolic Pathway Regulation in Colorectal Cancer.
2021International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antiproliferative Properties of 7,8-Ethylene Diamine Chelator-Lipophilic Fluoroquinolone Derivatives Against Colorectal Cancer Cell Lines.
2022Anti-cancer agents in medicinal chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ligiamycins A and B, Decalin-Amino-Maleimides from the Co-Culture of Streptomyces sp. and Achromobacter sp. Isolated from the Marine Wharf Roach, Ligia exotica.
2022Marine drugs
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[A Preliminary Study on the Effect of CD47-Targeted Immunotherapy on Oral-Gut Microbiota].
2022Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Flavonoid Intake in Relation to Colorectal Cancer Risk and Blood Bacterial DNA.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oxathiazinane derivatives display both antineoplastic and antibacterial activity: a structure activity study.
2023Journal of cancer research and clinical oncology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enhancement of physicochemical characterization of nanocomposites on Ag+/Fe2+ codoped hydroxyapatite for antibacterial and anticancer properties.
2023Colloids and surfaces. B, Biointerfaces
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prevalence, Microbiological Profile, and Risk Factors of Surgical Site Infections in Saudi Patients with Colorectal Cancer.
2023Saudi journal of medicine & medical sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel family of [RuCp(N,N)(P)]+ compounds with simultaneous anticancer and antibacterial activity: Biological evaluation and solution chemistry studies.
2023European journal of medicinal chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antimicrobial, Anticancer, and Antioxidant Activities of Maize and Clover Pollen Grains Extracts: A Comparative Study with Phytochemical Characterizations.
2023Pharmaceuticals (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Evaluation of the Phenolic Composition and Biological Activities of Six Aqueous Date (Phoenix dactylifera L.) Seed Extracts Originating from Different Countries: A Comparative Analysis.
2023Foods (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Antibacterial, antibiofilm, and anticancer activity of silver-nanoparticles synthesized from the cell-filtrate of Streptomyces enissocaesilis.
2024BMC biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of p-coumaric acid on probiotic properties of Lactobacillus acidophilus LA-5 and lacticaseibacillus rhamnosus GG.
2024Archives of microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Biomimetic piezoelectric nanomaterial-modified oral microrobots for targeted catalytic and immunotherapy of colorectal cancer.
2024Science advances
Disease-relevant preclinical or model-based paper useful as supporting evidence.
An In Vitro Study on the Cytotoxic, Antioxidant, and Antimicrobial Properties of Yamogenin-A Plant Steroidal Saponin and Evaluation of Its Mechanism of Action in Gastric Cancer Cells.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Catalase-positive Staphylococcus epidermidis based cryo-millineedle platform facilitates the photo-immunotherapy against colorectal cancer via hypoxia improvement.
2024Journal of colloid and interface science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Phylosymbiosis and Elevated Cancer Risk in Genetically Depauperate Channel Island Foxes.
2025Molecular ecology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
In vitro antimicrobial and cytotoxic potential against colorectal cancer cell lines using ethanolic leaf extract of Sansevieria trifasciata (Agavaceae).
2024Indian journal of pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Magnetically triggered thermoelectric heterojunctions with an efficient magnetic-thermo-electric energy cascade conversion for synergistic cancer therapy.
2025Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pterostilbene Exhibited the Anticancer Effect Against 1, 2-Dimethylhydrazine (DMH)-Induced Colorectal Cancer via Alteration of Oxidative Stress, Inflammation and Gut Microbiota.
2025Journal of biochemical and molecular toxicology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series.
2025EJHaem
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Escherichia coli Sternoclavicular Septic Arthritis Secondary to Colon Cancer-associated Bacteremia.
2025Internal medicine (Tokyo, Japan)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
VSIG4-Expressing Macrophages Contribute to Antiparasitic and Antimetastatic Responses in the Peritoneal Cavity.
2025European journal of immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eubacterium limosum modulates tumor microenvironments and produces antitumor metabolites active against colorectal cancer.
2025The ISME journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Qingjie Fuzheng Granule prevents colitis-associated colorectal cancer by inhibiting abnormal activation of NOD2/NF-κB signaling pathway mediated by gut microbiota disorder.
2025Chinese herbal medicines
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
3 papersClostridium difficile, the Difficult "Kloster" Fuelled by Antibiotics.
2019Current microbiology
Relevant review or meta-analysis for the signal-disease area.
Traditional application and modern pharmacological research of Artemisia annua L.
2020Pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.