preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
candidateweakhigh inflation risk
Staphylococcus
autism
Staphylococcus has meaningful literature visibility in autism, but the current evidence mix suggests a substantial risk of overclaiming.
Staphylococcus has a broader but less central evidence footprint in autism, with support coming from indirect, review, or preclinical literature.
staphylococcus
Credibility score
7
Human translation
2/5
Reproducibility
1/5
Novelty
5/5
Actionability
1/5
Credibility 7Human translation 2/5Reproducibility 1/5Novelty 5/5Actionability 1/5
Why this scores the way it does
- meaningful supporting human literature
Main caveats
- preclinical evidence outweighs human evidence
- limited central evidence
Internal review flags
1 flagsPrimary central evidence
1 papersGut Microbiota Ecology and Inferred Functions in Children With ASD Compared to Neurotypical Subjects.
2022Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersBacterial variation in the oral microbiota in multiple sclerosis patients.
2021PloS one
Human primary paper with plausible association relevance to the disease context.
Autologous umbilical cord blood infusion for the treatment of autism in young children: A within-subjects open label study on safety (assessed via caregiver report) and efficacy.
2024Autism research : official journal of the International Society for Autism Research
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
4 papersThe Independent and Combined Effects of Omega-3 and Vitamin B12 in Ameliorating Propionic Acid Induced Biochemical Features in Juvenile Rats as Rodent Model of Autism.
2018Journal of molecular neuroscience : MN
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Risk of Major Mental Disorder after Severe Bacterial Infections in Children and Adolescents: A Nationwide Longitudinal Study.
2022Neuropsychobiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Induction of core symptoms of autism spectrum disorder by in vivo CRISPR/Cas9-based gene editing in the brain of adolescent rhesus monkeys.
2021Science bulletin
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Therapeutic efficacy of sulforaphane in autism spectrum disorders and its association with gut microbiota: animal model and human longitudinal studies.
2023Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersThe microbiota, chemical symbiosis, and human disease.
2014Journal of molecular biology
Relevant review or meta-analysis for the signal-disease area.