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supportedmidmoderate inflation risk

Shannon diversity

autism

Shannon diversity is an interesting but still moderate-confidence signal in autism.

Shannon diversity shows a moderate evidence base in autism, with multiple central papers and additional supporting literature.

shannon_diversity
Credibility score
39
Human translation
3/5
Reproducibility
3/5
Novelty
3/5
Actionability
3/5
Credibility 39Human translation 3/5Reproducibility 3/5Novelty 3/5Actionability 3/5
Why this scores the way it does
  • moderate central evidence base
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

11 papers
Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified.
2013
PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Correlation between gut microbiota and behavior symptoms in children with autism spectrum disorder].
2019
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Association between the clinical efficacy of fecal microbiota transplantation in recipients and the choice of donor].
2020
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Imbalance in the Gut Microbiota of Children With Autism Spectrum Disorders.
2021
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Individual Brain Morphological Connectome Indicator Based on Jensen-Shannon Divergence Similarity Estimation for Autism Spectrum Disorder Identification.
2022
Frontiers in neuroscience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism.
2022
Brain, behavior, and immunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Establishment and preliminary clinical application of human intestinal fluid transplantation].
2022
Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Diversity and functional prediction of gut microbiota in children with autism spectrum disorder].
2022
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A comparative study on dietary diversity and gut microbial diversity in children with autism spectrum disorder, attention-deficit hyperactivity disorder, their neurotypical siblings, and non-related neurotypical volunteers: a cross-sectional study.
2024
Journal of child psychology and psychiatry, and allied disciplines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome differences in children with Attention Deficit Hyperactivity Disorder and Autism Spectrum Disorder and effects of probiotic supplementation: A randomized controlled trial.
2025
Research in developmental disabilities
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Characterization of Gut Microbiota in Children with Autism Spectrum Disorder: Microbial Signatures and Modulation by Anti-Inflammatory Diet and Probiotics.
2025
Pharmaceuticals (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Heterozygous Variants in KMT2E Cause a Spectrum of Neurodevelopmental Disorders and Epilepsy.
2019
American journal of human genetics
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

9 papers
Mitochondrial Fatty Acid β-Oxidation and Resveratrol Effect in Fibroblasts from Patients with Autism Spectrum Disorder.
2021
Journal of personalized medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Attention/Deficit Hyperactivity Disorder in Adolescent and Young Adult Males With Fragile X Syndrome.
2022
American journal on intellectual and developmental disabilities
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Female zebrafish (Danio rerio) demonstrate stronger preference for established shoals over newly-formed shoals in the three-tank open-swim preference test.
2022
PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characteristics of children on the autism spectrum who benefit the most from receiving intervention in inclusive versus specialised early childhood education settings.
2022
Autism research : official journal of the International Society for Autism Research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Inductively coupled plasma mass spectrometry based urine metallome to construct clinical decision models for autism spectrum disorder.
2022
Metallomics : integrated biometal science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Barriers to Providing Transitional Supports for Autistic Students: Insights of School Professionals.
2025
Journal of autism and developmental disorders
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterizing Occupational Therapy Intervention for Children on the Autism Spectrum.
2024
The American journal of occupational therapy : official publication of the American Occupational Therapy Association
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Brain functional connectivity correlates of autism diagnosis and familial liability in 24-month-olds.
2025
Journal of neurodevelopmental disorders
Disease-relevant preclinical or model-based paper useful as supporting evidence.
3KO-NSCs ameliorate behavioral deficits and modulate gut microbiota in a VPA-induced C57BL/6 mouse model of autism.
2025
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

9 papers
Environmental evaluation of a child with developmental disability.
2007
Pediatric clinics of North America
Relevant review or meta-analysis for the signal-disease area.
Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria.
2013
Journal of the National Cancer Institute
Relevant review or meta-analysis for the signal-disease area.
What is the prevalence of autism spectrum disorder and ASD traits in psychosis? A systematic review.
2017
Psychiatry research
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in the High-Risk Construct of Severe Mental Disorders: A Mini Review.
2020
Frontiers in psychiatry
Relevant review or meta-analysis for the signal-disease area.
Interventions for Transition-Age Youth With Disabilities: A Meta-Analysis of Group Design Studies.
2022
American journal on intellectual and developmental disabilities
Relevant review or meta-analysis for the signal-disease area.
Feasibility and Impact of Integrating an Artificial Intelligence-Based Diagnosis Aid for Autism Into the Extension for Community Health Outcomes Autism Primary Care Model: Protocol for a Prospective Observational Study.
2022
JMIR research protocols
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
2023
Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Retrospective review: single- and multidonor washed microbiota transplantation have equivalent efficacy in the treatment of autism.
2025
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
AI-Enabled Technologies and Biomarker Analysis for the Early Identification of Autism and Related Neurodevelopmental Disorders.
2025
Children (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.