preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Shannon diversity
atopic dermatitis
Shannon diversity has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Shannon diversity shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
shannon_diversity
Credibility score
39
Human translation
2/5
Reproducibility
4/5
Novelty
4/5
Actionability
3/5
Credibility 39Human translation 2/5Reproducibility 4/5Novelty 4/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
10 papersEffect of an Emollient on the Mycobiome of Atopic Dermatitis Patients.
2018Journal of drugs in dermatology : JDD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood.
2020Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota development during infancy: Impact of introducing allergenic foods.
2021The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial.
2021Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The phageome in normal and inflamed human skin.
2023Science advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and plasma metabolites in pregnant mothers and infant atopic dermatitis: A multi-omics study.
2025The World Allergy Organization journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
ROCKET: a phase 3 program evaluating the efficacy and safety of rocatinlimab in moderate-to-severe atopic dermatitis.
2025Immunotherapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An Indole-Rich Postbiotic Reduces Itching in Dogs: A Randomized, Double-Blinded Placebo-Controlled Study.
2025Animals : an open access journal from MDPI
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Efficacy and Safety of Tralokinumab Across Racial Subgroups in Adults with Moderate-to-Severe Atopic Dermatitis: Post Hoc Analysis of Phase III Trials.
2026American journal of clinical dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of feeding type on gut microbiota and atopic dermatitis in cesarean delivered infants: a combined birth cohort study.
2026Food science of animal resources
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
4 papersChanges in Skin and Nasal Microbiome and Staphylococcal Species Following Treatment of Atopic Dermatitis with Dupilumab.
2021Microorganisms
Human primary paper with plausible association relevance to the disease context.
Study of The specificity of gut microbiota in adult patients with delayed-onset of atopic dermatitis.
2022Allergologia et immunopathologia
Human primary paper with plausible association relevance to the disease context.
Multi-omics analysis of Gwakhyangjeonggi-san for gastrointestinal complications in atopic dermatitis: A randomized, double-blinded, placebo-controlled, parallel-group clinical trial.
2024Journal of ethnopharmacology
Human primary paper with plausible association relevance to the disease context.
Associations between early-life exposures and the infant skin microbiome.
2026The British journal of dermatology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
18 papersEffects of a New Emollient-Based Treatment on Skin Microflora Balance and Barrier Function in Children with Mild Atopic Dermatitis.
2016Pediatric dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The influence of treatment in alpine and moderate maritime climate on the composition of the skin microbiome in patients with difficult to treat atopic dermatitis.
2019Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Apple cider vinegar soaks do not alter the skin bacterial microbiome in atopic dermatitis.
2021PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dupilumab Therapy Improves Stratum Corneum Hydration and Skin Dysbiosis in Patients With Atopic Dermatitis.
2021Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Heterogeneous origin of IgE in atopic dermatitis and psoriasis revealed by B cell receptor repertoire analysis.
2022Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Skin and Nose Microbiome and Its Association with Filaggrin Gene Mutations in Pediatric Atopic Dermatitis.
2022Dermatology (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparing the psychometric properties of the EQ-5D-3L and EQ-5D-5L descriptive systems and utilities in atopic dermatitis.
2023The European journal of health economics : HEPAC : health economics in prevention and care
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical niclosamide (ATx201) reduces Staphylococcus aureus colonization and increases Shannon diversity of the skin microbiome in atopic dermatitis patients in a randomized, double-blind, placebo-controlled Phase 2 trial.
2022Clinical and translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Limosilactobacillus reuteri FN041 prevents atopic dermatitis in pup mice by remodeling the ileal microbiota and regulating gene expression in Peyer's patches after vertical transmission.
2022Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin microbiome and its association with host cofactors in determining atopic dermatitis severity.
2023Journal of the European Academy of Dermatology and Venereology : JEADV
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tralokinumab treatment improves the skin microbiota by increasing the microbial diversity in adults with moderate-to-severe atopic dermatitis: Analysis of microbial diversity in ECZTRA 1, a randomized controlled trial.
2023Journal of the American Academy of Dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects on the Skin Microbiome by a Moisturizer Formulated for Eczema-Prone and Sensitive Skin.
2025Journal of drugs in dermatology : JDD
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Clinically Meaningful Improvements in Adolescents with Moderate-to-Severe Atopic Dermatitis Treated with Tralokinumab who did not Achieve Clear or Almost Clear Skin at Week 16.
2025Dermatology and therapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of a Gel Containing the Defined Microalgae Extract Spiralin® on the Skin Microbiome and Clinical Activity in Atopic Dermatitis: A Double-Blind, Intraindividual Vehicle-Controlled Proof-Of-Concept Study.
2025Skin pharmacology and physiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary modulation of gut microbiota and its role in atopic dermatitis: integrative evidence from animal and human studies.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Resilience of the Skin Microbiome in Atopic Dermatitis During Short-Term Topical Treatment.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Facial Skin Mycobiome in Atopic Dermatitis With and Without Facial Involvement and Healthy Controls: A Case-Control Study.
2026Experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel Therapeutic Approaches for Treating Moderate-to-Severe Atopic Dermatitis in Infants with Polyvalent Allergic Sensitisation.
2026Journal of mother and child
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersBiomarkers in Atopic Dermatitis: A Review of the Role of IL-13 and the Impact of Tralokinumab Treatment.
2025American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.