preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
candidatetophigh inflation risk
Saccharomyces
obesity
Saccharomyces has meaningful literature visibility in obesity, but the current evidence mix suggests a substantial risk of overclaiming.
Saccharomyces has a broader but less central evidence footprint in obesity, with support coming from indirect, review, or preclinical literature.
saccharomyces
Credibility score
38
Human translation
1/5
Reproducibility
5/5
Novelty
2/5
Actionability
1/5
Credibility 38Human translation 1/5Reproducibility 5/5Novelty 2/5Actionability 1/5
Why this scores the way it does
- dense review literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- review density exceeds central evidence depth
- retrieval noise or disease-specificity issues may remain
Internal review flags
2 flagsreview_heavy
Review literature is very dense relative to primary central evidence.
Primary central evidence
3 papersRelative Abundance in Bacterial and Fungal Gut Microbes in Obese Children: A Case Control Study.
2017Childhood obesity (Print)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Saccharomyces boulardii improves clinical and paraclinical indices in overweight/obese knee osteoarthritis patients: a randomized triple-blind placebo-controlled trial.
2024European journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Mycobiome in Atopic Dermatitis and in Overweight Young Children: A Prospective Cohort Study in Finland.
2024Journal of fungi (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersGut Mycobiota Dysbiosis Is Associated with Melanoma and Response to Anti-PD-1 Therapy.
2024Cancer immunology research
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
19 papersResveratrol improves health and survival of mice on a high-calorie diet.
2006Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Saccharomyces boulardii administration changes gut microbiota and reduces hepatic steatosis, low-grade inflammation, and fat mass in obese and type 2 diabetic db/db mice.
2014mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Baker's yeast (Saccharomyces cerevisiae) antigen in obese and normal weight subjects.
2015Clinical obesity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Obesity and the use of antibiotics and probiotics in rats.
2014Chemotherapy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Yeast with bacteriocin from ruminal bacteria enhances glucose utilization, reduces ectopic fat accumulation, and alters cecal microbiota in dietary-induced obese mice.
2015Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Obesity changes the human gut mycobiome.
2015Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs.
2019The Journal of biological chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pathophysiology of high fat diet induced obesity: impact of probiotic banana juice on obesity associated complications and hepatosteatosis.
2020Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The fecal mycobiome in non-alcoholic fatty liver disease.
2022Journal of hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Metabolic variables of obese dogs with insulin resistance supplemented with yeast beta-glucan.
2022BMC veterinary research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sequentially fermented dealcoholized apple juice intervenes fatty liver induced by high-fat diets via modulation of intestinal flora and gene pathways.
2022Food research international (Ottawa, Ont.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Yeast β-Glucan Improves Insulin Sensitivity and Hepatic Lipid Metabolism in Mice Humanized with Obese Type 2 Diabetic Gut Microbiota.
2022Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Probiotic Therapy with Lactobacillus acidophilus and Bifidobacterium animalis subsp. lactis Results in Infarct Size Limitation in Rats with Obesity and Chemically Induced Colitis.
2022Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Maturational patterns of the infant gut mycobiome are associated with early-life body mass index.
2023Cell reports. Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cold Exposure and Oral Delivery of GLP-1R Agonists by an Engineered Probiotic Yeast Strain Have Antiobesity Effects in Mice.
2023ACS synthetic biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Saccharomyces cerevisiae for abdominal pain and discomfort in irritable bowel syndrome patients.
2024Pakistan journal of medical sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Associations between bacterial and fungal communities in the human gut microbiota and their implications for nutritional status and body weight.
2024Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut mycobiome alterations in obesity in geographically different regions.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral Supplementation of Indole-3-acetic Acid Alleviates High-Fat-Induced Obesity by Activating the Gpha2-Mediated Thyroid-Stimulating Hormone Pathway.
2025Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
28 papersThinking globally and acting locally with TOR.
2006Current opinion in cell biology
Relevant review or meta-analysis for the signal-disease area.
Obese and anorexic yeasts: experimental models to understand the metabolic syndrome and lipotoxicity.
2010Biochimica et biophysica acta
Relevant review or meta-analysis for the signal-disease area.
Probiotics: an update.
2015Jornal de pediatria
Relevant review or meta-analysis for the signal-disease area.
Erythropoietin and diabetes mellitus.
2015World journal of diabetes
Relevant review or meta-analysis for the signal-disease area.
[Fungi in the gut - the gut mycobiome].
2017Zeitschrift fur Gastroenterologie
Relevant review or meta-analysis for the signal-disease area.
Ten principles of heterochromatin formation and function.
2018Nature reviews. Molecular cell biology
Relevant review or meta-analysis for the signal-disease area.
Lipotoxicty in yeast: a focus on plasma membrane signalling and membrane contact sites.
2018FEMS yeast research
Relevant review or meta-analysis for the signal-disease area.
Probiotic Species in the Modulation of Gut Microbiota: An Overview.
2018BioMed research international
Relevant review or meta-analysis for the signal-disease area.
Pexophagy in yeast and mammals: an update on mysteries.
2018Histochemistry and cell biology
Relevant review or meta-analysis for the signal-disease area.
One Health, Fermented Foods, and Gut Microbiota.
2018Foods (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
The intriguing chemistry and biology of soraphens.
2019Natural product reports
Relevant review or meta-analysis for the signal-disease area.
Lipid Hydrolase Enzymes: Pragmatic Prolongevity Targets for Improved Human Healthspan?
2020Rejuvenation research
Relevant review or meta-analysis for the signal-disease area.
Sugar reduction in bakery products: Current strategies and sourdough technology as a potential novel approach.
2019Food research international (Ottawa, Ont.)
Relevant review or meta-analysis for the signal-disease area.
[Probiotics: benefits and harms].
2020Revue medicale suisse
Relevant review or meta-analysis for the signal-disease area.
Yeast Beta-Glucans Ingestion Does Not Influence Body Weight: A Systematic Review and Meta-Analysis of Pre-Clinical Studies.
2021Nutrients
Relevant review or meta-analysis for the signal-disease area.
Current understanding of antibiotic-associated dysbiosis and approaches for its management.
2023Therapeutic advances in infectious disease
Relevant review or meta-analysis for the signal-disease area.
Early-Life Antibiotics and Childhood Obesity: Yeast Probiotics as a Strategy to Modulate Gut Microbiota.
2023Cureus
Relevant review or meta-analysis for the signal-disease area.
Gut mycobiome and metabolic diseases: The known, the unknown, and the future.
2023Pharmacological research
Relevant review or meta-analysis for the signal-disease area.
Acyl coenzyme A binding protein (ACBP): An aging- and disease-relevant "autophagy checkpoint".
2023Aging cell
Relevant review or meta-analysis for the signal-disease area.
Investigating the Efficacy of Saccharomyces boulardii in Metabolic Syndrome Treatment: A Narrative Review of What Is Known So Far.
2023International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
The Associations of Auto-Brewery Syndrome and Diabetes Mellitus: A Literature Review and Clinical Perspective.
2023Cureus
Relevant review or meta-analysis for the signal-disease area.
Innovative therapeutic strategies for cardiovascular disease.
2023EXCLI journal
Relevant review or meta-analysis for the signal-disease area.
Does the ketogenic diet improve neurological disorders by influencing gut microbiota? A systematic review.
2023Nutrition journal
Relevant review or meta-analysis for the signal-disease area.
Kombucha as a Health-Beneficial Drink for Human Health.
2024Plant foods for human nutrition (Dordrecht, Netherlands)
Relevant review or meta-analysis for the signal-disease area.
The evidence for probiotics in the treatment of digestive disorders in the pediatric population.
2025Journal of gastroenterology and hepatology
Relevant review or meta-analysis for the signal-disease area.
A comprehensive review of probiotics and human health-current prospective and applications.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Genetic engineering of Saccharomyces boulardii: Tools, strategies and advances for enhanced probiotic and therapeutic applications.
2025Biotechnology advances
Relevant review or meta-analysis for the signal-disease area.
Systematic review and meta-analysis of bioactive hydrolysates derived from Saccharomyces cerevisiae on obesity management.
2025BMC complementary medicine and therapies
Relevant review or meta-analysis for the signal-disease area.