preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Saccharomyces
autism
Saccharomyces has meaningful literature visibility in autism, but the current evidence mix suggests a substantial risk of overclaiming.
Saccharomyces shows a moderate evidence base in autism, with multiple central papers and additional supporting literature.
saccharomyces
Credibility score
28
Human translation
2/5
Reproducibility
3/5
Novelty
4/5
Actionability
2/5
Credibility 28Human translation 2/5Reproducibility 3/5Novelty 4/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- retrieval noise or disease-specificity issues may remain
Internal review flags
1 flagsPrimary central evidence
7 papersPediatric inflammatory bowel disease: clinical and therapeutic aspects.
2001Current opinion in gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A comprehensive functional analysis of PTEN mutations: implications in tumor- and autism-related syndromes.
2011Human molecular genetics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Rare deleterious mutations of the gene EFR3A in autism spectrum disorders.
2014Molecular autism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Expression of Human PTEN-L in a Yeast Heterologous Model Unveils Specific N-Terminal Motifs Controlling PTEN-L Subcellular Localization and Function.
2019Cells
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects and microbiota changes following oral lyophilized fecal microbiota transplantation in children with autism spectrum disorder.
2024Frontiers in pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A founder variant in TBCB is associated with global developmental delay, autism spectrum, and spastic paraparesis.
2025Genetics in medicine : official journal of the American College of Medical Genetics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bimodal distribution of intestinal Candida in children with autism and its potential link with worse ASD symptoms.
2024Gut microbes reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersKinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids.
2010Cell
Human primary paper with plausible association relevance to the disease context.
The Na+(K+)/H+ exchanger Nhx1 controls multivesicular body-vacuolar lysosome fusion.
2018Molecular biology of the cell
Human primary paper with plausible association relevance to the disease context.
Dysbiosis of Gut Fungal Microbiota in Children with Autism Spectrum Disorders.
2021Journal of autism and developmental disorders
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
13 papersPsychiatric disorder-related abnormal behavior and habenulointerpeduncular pathway defects in Wnt1-cre and Wnt1-GAL4 double transgenic mice.
2013Journal of neurochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Functional evaluation of autism-associated mutations in NHE9.
2013Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
LEGO: a novel method for gene set over-representation analysis by incorporating network-based gene weights.
2016Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Truncating Variants in NAA15 Are Associated with Variable Levels of Intellectual Disability, Autism Spectrum Disorder, and Congenital Anomalies.
2018American journal of human genetics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Reduction in Obsessive Compulsive Disorder and Self-Injurious Behavior With Saccharomyces boulardii in a Child with Autism: A Case Report.
2018Integrative medicine (Encinitas, Calif.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multi-model functionalization of disease-associated PTEN missense mutations identifies multiple molecular mechanisms underlying protein dysfunction.
2020Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
CoCoCoNet: conserved and comparative co-expression across a diverse set of species.
2020Nucleic acids research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Case Study: Rapid Complete Recovery From An Autism Spectrum Disorder After Treatment of Aspergillus With The Antifungal Drugs Itraconazole And Sporanox.
2020Integrative medicine (Encinitas, Calif.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
40S ribosome profiling reveals distinct roles for Tma20/Tma22 (MCT-1/DENR) and Tma64 (eIF2D) in 40S subunit recycling.
2021Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
NOS1AP Interacts with α-Synuclein and Aggregates in Yeast and Mammalian Cells.
2022International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2.
2024Neurochemistry international
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Revealing function-altering MECP2 mutations in individuals with autism spectrum disorder using yeast and Drosophila.
2025Genetics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Catalase Gene Variants and Oxidative Stress in Autism Spectrum Disorder: A Northern Lebanon Cohort and Aripiprazole In Vitro Toxicity.
2025International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
2 papersA comprehensive review on DDX3X liquid phase condensation in health and neurodevelopmental disorders.
2024International journal of biological macromolecules
Relevant review or meta-analysis for the signal-disease area.
Gut mycobiome and neuropsychiatric disorders: insights and therapeutic potential.
2024Frontiers in cellular neuroscience
Relevant review or meta-analysis for the signal-disease area.