preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Saccharomyces
atopic dermatitis
Saccharomyces has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Saccharomyces has a broader but less central evidence footprint in atopic dermatitis, with support coming from indirect, review, or preclinical literature.
saccharomyces
Credibility score
22
Human translation
2/5
Reproducibility
4/5
Novelty
4/5
Actionability
1/5
Credibility 22Human translation 2/5Reproducibility 4/5Novelty 4/5Actionability 1/5
Why this scores the way it does
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
- limited central evidence
Internal review flags
1 flagsPrimary central evidence
2 papersLooking for immunotolerance: a case of allergy to baker's yeast (Saccharomyces cerevisiae).
2005European annals of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Mycobiome in Atopic Dermatitis and in Overweight Young Children: A Prospective Cohort Study in Finland.
2024Journal of fungi (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
4 papersSaccharomyces cerevisiae as a skin physiology, pathology, and treatment model.
2020Dermatology online journal
Human primary paper with plausible association relevance to the disease context.
IgE-binding components of baker's yeast (Saccharomyces cerevisiae) recognized by immunoblotting analysis. Simultaneous IgE binding to mannan and 46-48 kD allergens of Saccharomyces cerevisiae and Candida albicans.
1993Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Human primary paper with plausible association relevance to the disease context.
IgE antibodies to protein and mannan antigens of pityrosporum ovale in atopic dermatitis patients.
1997Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Human primary paper with plausible association relevance to the disease context.
IgE, IgA, and IgG responses to common yeasts in atopic patients.
1998Allergy
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
12 papersOverproduction of Th2-specific chemokines in NC/Nga mice exhibiting atopic dermatitis-like lesions.
1999The Journal of clinical investigation
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cross-reacting IgE and IgG antibodies to Pityrosporum ovale mannan and other yeasts in atopic dermatitis.
1999Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
IgG and IgE immune response against the surface glycoprotein gp200 of Saccharomyces cerevisiae in patients with atopic dermatitis.
2001Mycopathologia
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hydrocortisone-loaded poly(ε-caprolactone) nanoparticles for atopic dermatitis treatment.
2013Pharmaceutical development and technology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Yeast-Derived Nucleotides Enhance Fibroblast Migration and Proliferation and Provide Clinical Benefits in Atopic Dermatitis.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Saccharomyces boulardii (CNCM I-745) ameliorates Ovalbumin-induced atopic dermatitis by modulating the NF-κB signaling in skin and colon.
2025Archives of dermatological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Skin Mycobiome of Patients With Atopic Dermatitis and Healthy Volunteers: A Case-Control Study.
2025Experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical Administration of a Mixed Microbial Culture of Lactobacillus paracasei, Pichia membranifaciens and Saccharomyces cerevisiae Significantly Inhibits the Development of Atopic Dermatitis in a Mouse Model Through IL-10 Overexpression by Dendritic Cells.
2025Biomedicines
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Decreased phagocytic capacity of the neutrophil leucocytes in patients with atopic dermatitis.
1973Acta dermato-venereologica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Immediate hypersensitivity to bakery, brewery and wine products in yeast-sensitive atopic dermatitis patients.
1994Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nitrocellulose-RAST analysis of allergenic cross-reactivity of Candida albicans and Saccharomyces cerevisiae mannans.
1995International archives of allergy and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin prick test reactions to brewer's yeast (Saccharomyces cerevisiae) in adult atopic dermatitis patients.
1993Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
7 papersProbiotics.
2008American family physician
Relevant review or meta-analysis for the signal-disease area.
Botanicals in dermatology: an evidence-based review.
2010American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.
2011Diabetes/metabolism research and reviews
Relevant review or meta-analysis for the signal-disease area.
[Effectiveness and safety of probiotics in children on the basis of clinical trials].
2012Medycyna wieku rozwojowego
Relevant review or meta-analysis for the signal-disease area.
Probiotics and prebiotics in infants and children.
2013Current infectious disease reports
Relevant review or meta-analysis for the signal-disease area.
A review of dose-responses of probiotics in human studies.
2017Beneficial microbes
Relevant review or meta-analysis for the signal-disease area.
Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG.
2022Archivos argentinos de pediatria
Relevant review or meta-analysis for the signal-disease area.