sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Ruminococcus torques
ulcerative colitis
Ruminococcus torques looks like a credible signal in ulcerative colitis, though some caution is still warranted.
Ruminococcus torques shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.
ruminococcus_torques
Credibility score
66
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 66Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
22 papersAbnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis.
2006Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Markers of dysbiosis in patients with ulcerative colitis and Crohn's disease.
2019Terapevticheskii arkhiv
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A randomized controlled trial investigating the effect of a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols on the intestinal microbiome and inflammation in patients with ulcerative colitis: study protocol for a randomized controlled trial.
2020Trials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations.
2020Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome Analysis of Mucosal Ileoanal Pouch in Ulcerative Colitis Patients Revealed Impairment of the Pouches Immunometabolites.
2021Cells
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of gut microbiome and transcriptome changes in ulcerative colitis and pouchitis.
2022Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Metabolites and Gut Microbes between Patients with Ulcerative Colitis and Healthy Individuals for an Integrative Medicine Approach to Ulcerative Colitis-A Pilot Observational Clinical Study (STROBE Compliant).
2022Diagnostics (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ethnicity Associated Microbial and Metabonomic Profiling in Newly Diagnosed Ulcerative Colitis.
2022Clinical and experimental gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal metabolome and its determinants in inflammatory bowel disease.
2023Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial.
2023Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in gut microbiota and fecal bile acids between Caucasian and Hispanic children and young adults with ulcerative colitis.
2023Physiological reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fermentation patterns of prebiotics fructooligosaccharides-SCFA esters inoculated with fecal microbiota from ulcerative colitis patients.
2023Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients.
2024Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Archaea influence composition of endoscopically visible ileocolonic biofilms.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reduced gut microbiota diversity in ulcerative colitis patients with latent tuberculosis infection during vedolizumab therapy: insights on prophylactic anti-tuberculosis effects.
2024BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
New potential biomarkers of ulcerative colitis and disease course - integrated metagenomic and metabolomic analysis among Polish patients.
2025Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota profiling in Lebanese ulcerative colitis patients and healthy controls from a pilot study.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
18 papersMucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria.
2010The American journal of gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
2020Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Periodontitis Salivary Microbiota Worsens Colitis.
2022Journal of dental research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kui Jie Tong Ameliorates Ulcerative Colitis by Regulating Gut Microbiota and NLRP3/Caspase-1 Classical Pyroptosis Signaling Pathway.
2022Disease markers
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Study of the gut microbiome in Egyptian patients with active ulcerative colitis.
2023Revista de gastroenterologia de Mexico (English)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
β-Glucan alleviates mice with ulcerative colitis through interactions between gut microbes and amino acids metabolism.
2023Journal of the science of food and agriculture
Disease-relevant preclinical or model-based paper useful as supporting evidence.
κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
2023International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients.
2023Journal of clinical biochemistry and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of three Chinese herbal therapies on gut microbiota and short-chain fatty acid metabolism in patients with mild, moderate, and severe ulcerative colitis: Multi-center, randomized, controlled trials.
2025International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enteromorpha prolifera soluble dietary fiber alleviates ulcerative colitis through restoration of mucosal barrier and gut microbiota homeostasis.
2025Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota causally affects ulcerative colitis by potential mediation of plasma metabolites: A Mendelian randomization study.
2025Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Metabolomics and Gut Microbiome Analysis Reveal the Role of Demethylzeylasteral in Alleviating Ulcerative Colitis in Mice.
2025Journal of proteome research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Magnoflorine alleviates colitis-induced anxiety-like behaviors by regulating gut microbiota and microglia-mediated neuroinflammation.
2025Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Banxia Xiexin Decoction prevents colitis by modulating gut microbiota and enhancing defensin and immunoglobulin A production.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lycium barbarum polysaccharides and/or Bifidobacterium longum exert anti-inflammation and modulate gut microbiota in rats with dextran sulfate sodium-induced ulcerative colitis.
2026International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersEpidemiology of fibrostenosing inflammatory bowel disease.
2020Journal of digestive diseases
Relevant review or meta-analysis for the signal-disease area.
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.
2021Gut
Relevant review or meta-analysis for the signal-disease area.
Ruminococcus gnavus bacteremia: Literature review and a case report associated with acute flare of ulcerative colitis in an immunocompromised patient.
2023Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis.
2025Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Relevant review or meta-analysis for the signal-disease area.