sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Ruminococcus torques
crohn's disease
Ruminococcus torques looks like a credible signal in crohn's disease, though some caution is still warranted.
Ruminococcus torques shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
ruminococcus_torques
Credibility score
76
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 76Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
25 papersAbnormal microbiota composition in the ileocolonic mucosa of Crohn's disease patients as revealed by polymerase chain reaction-denaturing gradient gel electrophoresis.
2006Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota in pediatric inflammatory bowel disease.
2010The Journal of pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome.
2010World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives.
2011Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reduced Abundance of Butyrate-Producing Bacteria Species in the Fecal Microbial Community in Crohn's Disease.
2016Digestion
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Consistent Prebiotic Effect on Gut Microbiota With Altered FODMAP Intake in Patients with Crohn's Disease: A Randomised, Controlled Cross-Over Trial of Well-Defined Diets.
2016Clinical and translational gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.
2017Lancet (London, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.
2017Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Variation of Gut Mucosal Microbiome With Anti-Saccharomyces cerevisiae Antibody Status in Pediatric Crohn Disease.
2019Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Development of a Novel Metagenomic Biomarker for Prediction of Upper Gastrointestinal Tract Involvement in Patients With Crohn's Disease.
2020Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal and mucosal microbiota profiling in pediatric inflammatory bowel diseases.
2021European journal of gastroenterology & hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Skin and Gut Microbiome in Hidradenitis Suppurativa.
2022The Journal of investigative dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome Analysis of Mucosal Ileoanal Pouch in Ulcerative Colitis Patients Revealed Impairment of the Pouches Immunometabolites.
2021Cells
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridioides difficile infection.
2023Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal metabolome and its determinants in inflammatory bowel disease.
2023Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Grape seed proanthocyanidin improves intestinal inflammation in canine through regulating gut microbiota and bile acid compositions.
2023FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between Exposure to Metals during Pregnancy, Childhood Gut Microbiome, and Risk of Intestinal Inflammation in Late Childhood.
2024Environment & health (Washington, D.C.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Deciphering the Interplay Among Inflammatory Bowel Disease, Gut Microbiota, and Inflammatory Biomarkers in the Risk of Colorectal Cancer.
2025Mediators of inflammation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolomics reveal distinct molecular pathways associated with future risk of Crohn's Disease.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Two-Dimensional PCR for Simultaneous Detection of Fecal Bacterial Markers in the Diagnosis and Management of Inflammatory Bowel Disease.
2026Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
20 papersFaecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients.
2008Proceedings of the National Academy of Sciences of the United States of America
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria.
2010The American journal of gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
2020Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine.
2020Immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3.
2021eLife
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Periodontitis Salivary Microbiota Worsens Colitis.
2022Journal of dental research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Supplementation With Chinese Medicinal Plant Extracts From Lonicera hypoglauca and Scutellaria baicalensis Mitigates Colonic Inflammation by Regulating Oxidative Stress and Gut Microbiota in a Colitis Mouse Model.
2021Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.
2023Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont.
2023Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron.
2024bioRxiv : the preprint server for biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ruminococcus torques is a keystone degrader of intestinal mucin glycoprotein, releasing oligosaccharides used by Bacteroides thetaiotaomicron.
2024mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation.
2025Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.
2025Behavioral and brain functions : BBF
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Magnoflorine alleviates colitis-induced anxiety-like behaviors by regulating gut microbiota and microglia-mediated neuroinflammation.
2025Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ruminococcus torques ameliorates the inflammation bowel disease and gut barrier dysfunction by modulating gut microbiota and bile acid metabolism.
2025Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Immunoinformatic-based design of a multi-epitope subunit vaccine against Ruminococcus torques using subtractive proteomics and molecular dynamics simulations.
2026Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
7 papersMicrobial genes and pathways in inflammatory bowel disease.
2019Nature reviews. Microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome: Profound Implications for Diet and Disease.
2019Nutrients
Relevant review or meta-analysis for the signal-disease area.
Epidemiology of fibrostenosing inflammatory bowel disease.
2020Journal of digestive diseases
Relevant review or meta-analysis for the signal-disease area.
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.
2021Gut
Relevant review or meta-analysis for the signal-disease area.
Alteration of the Gut Microbiome in Inflammatory Bowel Disease.
2023Digestion
Relevant review or meta-analysis for the signal-disease area.
Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments.
2024Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.