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Ruminococcus gnavus

ulcerative colitis

Ruminococcus gnavus looks like a credible signal in ulcerative colitis, though some caution is still warranted.

Ruminococcus gnavus shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.

ruminococcus_gnavus
Credibility score
98
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 98Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Internal review flags

1 flags
sparse_primary_supporting_bucket

Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.

Primary central evidence

34 papers
A pyrosequencing study in twins shows that gastrointestinal microbial profiles vary with inflammatory bowel disease phenotypes.
2010
Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial shifts and signatures of long-term remission in ulcerative colitis after faecal microbiota transplantation.
2017
The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome.
2019
Clinical and experimental gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Markers of dysbiosis in patients with ulcerative colitis and Crohn's disease.
2019
Terapevticheskii arkhiv
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predominantly Antibiotic-resistant Intestinal Microbiome Persists in Patients With Pouchitis Who Respond to Antibiotic Therapy.
2020
Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A randomized controlled trial investigating the effect of a diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols on the intestinal microbiome and inflammation in patients with ulcerative colitis: study protocol for a randomized controlled trial.
2020
Trials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations.
2020
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis in Metabolic Genes of the Gut Microbiomes of Patients with an Ileo-anal Pouch Resembles That Observed in Crohn's Disease.
2021
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis.
2021
Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-Term Efficacy of Low-Intensity Single Donor Fecal Microbiota Transplantation in Ulcerative Colitis and Outcome-Specific Gut Bacteria.
2021
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of gut microbiome and transcriptome changes in ulcerative colitis and pouchitis.
2022
Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease.
2023
Intestinal research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022
Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Metabolites and Gut Microbes between Patients with Ulcerative Colitis and Healthy Individuals for an Integrative Medicine Approach to Ulcerative Colitis-A Pilot Observational Clinical Study (STROBE Compliant).
2022
Diagnostics (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ethnicity Associated Microbial and Metabonomic Profiling in Newly Diagnosed Ulcerative Colitis.
2022
Clinical and experimental gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Efficacy of 1-kestose supplementation in patients with mild to moderate ulcerative colitis: A randomised, double-blind, placebo-controlled pilot study.
2023
Alimentary pharmacology & therapeutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal metabolome and its determinants in inflammatory bowel disease.
2023
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial.
2023
Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in gut microbiota and fecal bile acids between Caucasian and Hispanic children and young adults with ulcerative colitis.
2023
Physiological reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fermentation patterns of prebiotics fructooligosaccharides-SCFA esters inoculated with fecal microbiota from ulcerative colitis patients.
2023
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The impact of gut microbiome enterotypes on ulcerative colitis: identifying key bacterial species and revealing species co-occurrence networks using machine learning.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of microbial communities and the profile of sulfate-reducing bacteria in patients with ulcerative colitis and their association with bowel diseases: a pilot study.
2024
Microbial cell (Graz, Austria)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An integrative multi-omic analysis defines gut microbiota, mycobiota, and metabolic fingerprints in ulcerative colitis patients.
2024
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Archaea influence composition of endoscopically visible ileocolonic biofilms.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024
The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis.
2025
Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Small Intestinal Helminth Infection Alters Colonic Mucus and Shapes the Colonic Mucus Microbiome.
2024
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reduced gut microbiota diversity in ulcerative colitis patients with latent tuberculosis infection during vedolizumab therapy: insights on prophylactic anti-tuberculosis effects.
2024
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the gut phageome of Japanese patients with ulcerative colitis under endoscopic remission.
2025
Journal of clinical biochemistry and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Microbiota Diversity on Inflammatory Bowel Disease.
2025
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
New potential biomarkers of ulcerative colitis and disease course - integrated metagenomic and metabolomic analysis among Polish patients.
2025
Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota profiling in Lebanese ulcerative colitis patients and healthy controls from a pilot study.
2025
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial clusters are associated with the risk of severe disease progression in inflammatory bowel disease irrespective of conventional disease categories.
2026
Microbiome research reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and bile acids profiles study of ulcerative colitis and Crohn's disease patients.
2026
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Preclinical supporting evidence

22 papers
Mucolytic bacteria with increased prevalence in IBD mucosa augment in vitro utilization of mucin by other bacteria.
2010
The American journal of gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ruminococcus gnavus total hip arthroplasty infection in a 62-year-old man with ulcerative colitis.
2015
Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis.
2020
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
2020
Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC).
2021
BMC microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Periodontitis Salivary Microbiota Worsens Colitis.
2022
Journal of dental research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human Fecal Microbiota Transplantation Reduces the Susceptibility to Dextran Sulfate Sodium-Induced Germ-Free Mouse Colitis.
2022
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kui Jie Tong Ameliorates Ulcerative Colitis by Regulating Gut Microbiota and NLRP3/Caspase-1 Classical Pyroptosis Signaling Pathway.
2022
Disease markers
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Study of the gut microbiome in Egyptian patients with active ulcerative colitis.
2023
Revista de gastroenterologia de Mexico (English)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
β-Glucan alleviates mice with ulcerative colitis through interactions between gut microbes and amino acids metabolism.
2023
Journal of the science of food and agriculture
Disease-relevant preclinical or model-based paper useful as supporting evidence.
κ-Selenocarrageenan Oligosaccharides Prepared by Deep-Sea Enzyme Alleviate Inflammatory Responses and Modulate Gut Microbiota in Ulcerative Colitis Mice.
2023
International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients.
2023
Journal of clinical biochemistry and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mitochondrial dysfunction-associated microbiota establishes a transmissible refractory response to anti-TNF therapy during ulcerative colitis.
2023
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of three Chinese herbal therapies on gut microbiota and short-chain fatty acid metabolism in patients with mild, moderate, and severe ulcerative colitis: Multi-center, randomized, controlled trials.
2025
International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.
2025
Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganoderic Acid Ameliorates Ulcerative Colitis by Improving Intestinal Barrier Function via Gut Microbiota Modulation.
2025
International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enteromorpha prolifera soluble dietary fiber alleviates ulcerative colitis through restoration of mucosal barrier and gut microbiota homeostasis.
2025
Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota causally affects ulcerative colitis by potential mediation of plasma metabolites: A Mendelian randomization study.
2025
Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Metabolomics and Gut Microbiome Analysis Reveal the Role of Demethylzeylasteral in Alleviating Ulcerative Colitis in Mice.
2025
Journal of proteome research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Magnoflorine alleviates colitis-induced anxiety-like behaviors by regulating gut microbiota and microglia-mediated neuroinflammation.
2025
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Banxia Xiexin Decoction prevents colitis by modulating gut microbiota and enhancing defensin and immunoglobulin A production.
2025
Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

5 papers
Epidemiology of fibrostenosing inflammatory bowel disease.
2020
Journal of digestive diseases
Relevant review or meta-analysis for the signal-disease area.
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.
2021
Gut
Relevant review or meta-analysis for the signal-disease area.
Ruminococcus gnavus bacteremia: Literature review and a case report associated with acute flare of ulcerative colitis in an immunocompromised patient.
2023
Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis.
2025
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Relevant review or meta-analysis for the signal-disease area.
Ruminococcus gnavus Bacteremia in a SARS-CoV-2 Patient With Diverticulosis.
2025
Cureus
Relevant review or meta-analysis for the signal-disease area.