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Ruminococcus gnavus

inflammatory bowel disease

Ruminococcus gnavus looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.

Ruminococcus gnavus shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.

ruminococcus_gnavus
Credibility score
83
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 83Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • dense review literature
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

25 papers
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.
2017
Lancet (London, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal microbiota study reveals specific dysbiosis in spondyloarthritis.
2017
Annals of the rheumatic diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specificities of the intestinal microbiota in patients with inflammatory bowel disease and Clostridium difficile infection.
2018
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.
2017
Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.
2019
Proceedings of the National Academy of Sciences of the United States of America
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus.
2021
Proceedings of the National Academy of Sciences of the United States of America
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of gut microbiome and transcriptome changes in ulcerative colitis and pouchitis.
2022
Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Compositional changes in fecal microbiota associated with clinical phenotypes and prognosis in Korean patients with inflammatory bowel disease.
2023
Intestinal research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022
Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023
Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Strains Colonizing Different Intestinal Sites within an Individual Are Derived from a Single Founder Population.
2023
mBio
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridioides difficile infection.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal metabolome and its determinants in inflammatory bowel disease.
2023
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Temperate bacteriophages infecting the mucin-degrading bacterium Ruminococcus gnavus from the human gut.
2023
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diarrheal-associated gut dysbiosis in cancer and inflammatory bowel disease patients is exacerbated by Clostridioides difficile infection.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evaluation of Bacterial and Fungal Biomarkers for Differentiation and Prognosis of Patients with Inflammatory Bowel Disease.
2023
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024
Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Archaea influence composition of endoscopically visible ileocolonic biofilms.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024
The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis.
2025
Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort.
2025
Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Deciphering the Interplay Among Inflammatory Bowel Disease, Gut Microbiota, and Inflammatory Biomarkers in the Risk of Colorectal Cancer.
2025
Mediators of inflammation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Microbiota Diversity on Inflammatory Bowel Disease.
2025
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial.
2025
Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Deep Sequencing of Crohn's Disease Lamina Propria Phagocytes Identifies Pathobionts and Correlates With Pro-Inflammatory Gene Expression.
2025
Inflammatory bowel diseases
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

17 papers
Diet rapidly and reproducibly alters the human gut microbiome.
2014
Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
2020
Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine.
2020
Immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Periodontitis Salivary Microbiota Worsens Colitis.
2022
Journal of dental research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human Fecal Microbiota Transplantation Reduces the Susceptibility to Dextran Sulfate Sodium-Induced Germ-Free Mouse Colitis.
2022
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Synthesis of the pentasaccharide repeating unit from Ruminococcus gnavus and measurement of its inflammatory properties.
2021
RSC advances
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of the mucin-glycan foraging Ruminococcus gnavus in the communication between the gut and the brain.
2022
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.
2023
Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024
Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Metagenomic global survey and in-depth genomic analyses of Ruminococcus gnavus reveal differences across host lifestyle and health status.
2025
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.
2025
Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation.
2025
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Subtractive proteomics and reverse-vaccinology approaches for novel drug targets and designing a chimeric vaccine against Ruminococcus gnavus strain RJX1120.
2025
Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A core human gut microbe, Mediterraneibacter gnavus, produces a broad-spectrum bacteriocin mediterrocin.
2025
mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Magnoflorine alleviates colitis-induced anxiety-like behaviors by regulating gut microbiota and microglia-mediated neuroinflammation.
2025
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ruminococcus torques ameliorates the inflammation bowel disease and gut barrier dysfunction by modulating gut microbiota and bile acid metabolism.
2025
Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

14 papers
Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases?
2013
Best practice & research. Clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Microbial genes and pathways in inflammatory bowel disease.
2019
Nature reviews. Microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome: Profound Implications for Diet and Disease.
2019
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Epidemiology of fibrostenosing inflammatory bowel disease.
2020
Journal of digestive diseases
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Profile in Pediatric Patients With Inflammatory Bowel Disease: A Systematic Review.
2021
Frontiers in pediatrics
Relevant review or meta-analysis for the signal-disease area.
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.
2021
Gut
Relevant review or meta-analysis for the signal-disease area.
Alteration of the Gut Microbiome in Inflammatory Bowel Disease.
2023
Digestion
Relevant review or meta-analysis for the signal-disease area.
Ruminococcus gnavus bacteremia: Literature review and a case report associated with acute flare of ulcerative colitis in an immunocompromised patient.
2023
Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments.
2024
Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Gut bacteriome in inflammatory bowel disease: An update on recent advances.
2024
Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus.
2024
Diabetes, metabolic syndrome and obesity : targets and therapy
Relevant review or meta-analysis for the signal-disease area.
Dysbiosis in Inflammatory Bowel Disease and Spondyloarthritis: Still a Long Way to Go?
2024
Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Hidradenitis Suppurativa from a Multi-Omic Scope.
2025
Journal of cutaneous medicine and surgery
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.