Ribosomal DNA sequence analysis of mucosa-associated bacteria in Crohn's disease.
2004Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Ruminococcus gnavus
crohn's disease
Ruminococcus gnavus looks like a credible signal in crohn's disease, though some caution is still warranted.
Ruminococcus gnavus shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
ruminococcus_gnavus
Credibility score
95
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 95Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Primary central evidence
30 papersMicrobiota in pediatric inflammatory bowel disease.
2010The Journal of pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Structural robustness of the gut mucosal microbiota is associated with Crohn's disease remission after surgery.
2016Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study.
2017Lancet (London, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A novel Ruminococcus gnavus clade enriched in inflammatory bowel disease patients.
2017Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.
2019Proceedings of the National Academy of Sciences of the United States of America
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal and mucosal microbiota profiling in pediatric inflammatory bowel diseases.
2021European journal of gastroenterology & hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Capsular polysaccharide correlates with immune response to the human gut microbe Ruminococcus gnavus.
2021Proceedings of the National Academy of Sciences of the United States of America
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Skin and Gut Microbiome in Hidradenitis Suppurativa.
2022The Journal of investigative dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of gut microbiome and transcriptome changes in ulcerative colitis and pouchitis.
2022Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and mycobiome in inflammatory bowel disease patients with Clostridioides difficile infection.
2023Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Faecal metabolome and its determinants in inflammatory bowel disease.
2023Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Temperate bacteriophages infecting the mucin-degrading bacterium Ruminococcus gnavus from the human gut.
2023Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in gut microbiota and fecal bile acids between Caucasian and Hispanic children and young adults with ulcerative colitis.
2023Physiological reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Pre-Diagnosis Diet Predicts Response to Exclusive Enteral Nutrition and Correlates with Microbiome in Pediatric Crohn Disease.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Archaea influence composition of endoscopically visible ileocolonic biofilms.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Core microbiome-associated proteins associated with ulcerative colitis interact with cytokines for synergistic or antagonistic effects on gut bacteria.
2024The ISME journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific Bacterial Co-abundance Groups Are Associated With Inflammatory Status in Patients With Ulcerative Colitis.
2025Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mechanistic Implications of the Mediterranean Diet in Patients With Newly Diagnosed Crohn's Disease: Multiomic Results From a Prospective Cohort.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Deciphering the Interplay Among Inflammatory Bowel Disease, Gut Microbiota, and Inflammatory Biomarkers in the Risk of Colorectal Cancer.
2025Mediators of inflammation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Microbiota Diversity on Inflammatory Bowel Disease.
2025Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating Gut Microbiome and Metabolomics with Magnetic Resonance Enterography to Advance Bowel Damage Prediction in Crohn's Disease.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis-associated gut bacterium Ruminococcus gnavus varies at the strain level in its ability to utilize key mucin component sialic acid.
2025Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolomics reveal distinct molecular pathways associated with future risk of Crohn's Disease.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersAdalimumab Therapy Improves Intestinal Dysbiosis in Crohn's Disease.
2019Journal of clinical medicine
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
20 papersFaecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients.
2008Proceedings of the National Academy of Sciences of the United States of America
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Utilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent.
2013PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diet rapidly and reproducibly alters the human gut microbiome.
2014Nature
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice.
2016The ISME journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation.
2020Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine.
2020Immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrating taxonomic, functional, and strain-level profiling of diverse microbial communities with bioBakery 3.
2021eLife
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Periodontitis Salivary Microbiota Worsens Colitis.
2022Journal of dental research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Candida tropicalis Infection Modulates the Gut Microbiome and Confers Enhanced Susceptibility to Colitis in Mice.
2022Cellular and molecular gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human Fecal Microbiota Transplantation Reduces the Susceptibility to Dextran Sulfate Sodium-Induced Germ-Free Mouse Colitis.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The role of the mucin-glycan foraging Ruminococcus gnavus in the communication between the gut and the brain.
2022Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiome Composition Is Associated With Future Onset of Crohn's Disease in Healthy First-Degree Relatives.
2023Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fiber-deficient diet inhibits colitis through the regulation of the niche and metabolism of a gut pathobiont.
2023Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Balance between bile acid conjugation and hydrolysis activity can alter outcomes of gut inflammation.
2025Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiome and metabolomic alterations underlying colitis-induced encephalopathy in mice: mechanistic insight.
2025Behavioral and brain functions : BBF
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A core human gut microbe, Mediterraneibacter gnavus, produces a broad-spectrum bacteriocin mediterrocin.
2025mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Magnoflorine alleviates colitis-induced anxiety-like behaviors by regulating gut microbiota and microglia-mediated neuroinflammation.
2025Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
12 papersIntestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases?
2013Best practice & research. Clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Microbial genes and pathways in inflammatory bowel disease.
2019Nature reviews. Microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome: Profound Implications for Diet and Disease.
2019Nutrients
Relevant review or meta-analysis for the signal-disease area.
Epidemiology of fibrostenosing inflammatory bowel disease.
2020Journal of digestive diseases
Relevant review or meta-analysis for the signal-disease area.
Long-term dietary patterns are associated with pro-inflammatory and anti-inflammatory features of the gut microbiome.
2021Gut
Relevant review or meta-analysis for the signal-disease area.
Alteration of the Gut Microbiome in Inflammatory Bowel Disease.
2023Digestion
Relevant review or meta-analysis for the signal-disease area.
Ruminococcus gnavus bacteremia: Literature review and a case report associated with acute flare of ulcerative colitis in an immunocompromised patient.
2023Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Chronic Visceral Pain: New Peripheral Mechanistic Insights and Resulting Treatments.
2024Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus.
2024Diabetes, metabolic syndrome and obesity : targets and therapy
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis.
2025Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Relevant review or meta-analysis for the signal-disease area.
Unveiling Ruminococcus gnavus bacteremia: Clinical characteristics and implications.
2025Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.