sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Roseburia
ulcerative colitis
Roseburia looks like a credible signal in ulcerative colitis, though some caution is still warranted.
Roseburia shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.
roseburia
Credibility score
79
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 79Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
27 papersFluctuations in butyrate-producing bacteria in ulcerative colitis patients of North India.
2013World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A decrease of the butyrate-producing species Roseburia hominis and Faecalibacterium prausnitzii defines dysbiosis in patients with ulcerative colitis.
2014Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis.
2017World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Partners of patients with ulcerative colitis exhibit a biologically relevant dysbiosis in fecal microbial metacommunities.
2017World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Specific Bacteria and Metabolites Associated With Response to Fecal Microbiota Transplantation in Patients With Ulcerative Colitis.
2019Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Combined Signature of the Fecal Microbiome and Plasma Metabolome in Patients with Ulcerative Colitis.
2019Medical science monitor : international medical journal of experimental and clinical research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Butyryl-CoA:acetate CoA-transferase gene associated with the genus Roseburia is decreased in the gut microbiota of Japanese patients with ulcerative colitis.
2019Bioscience of microbiota, food and health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of soy milk consumption on gut microbiota, inflammatory markers, and disease severity in patients with ulcerative colitis: a study protocol for a randomized clinical trial.
2020Trials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adsorptive granulomonocytapheresis alters the gut bacterial microbiota in patients with active ulcerative colitis.
2021Journal of clinical apheresis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut dysbiosis and clinical phases of pancolitis in patients with ulcerative colitis.
2021MicrobiologyOpen
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis.
2021World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome Analysis of Mucosal Ileoanal Pouch in Ulcerative Colitis Patients Revealed Impairment of the Pouches Immunometabolites.
2021Cells
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-Term Efficacy of Low-Intensity Single Donor Fecal Microbiota Transplantation in Ulcerative Colitis and Outcome-Specific Gut Bacteria.
2021Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Xylo-Oligosaccharide on the Gut Microbiota of Patients With Ulcerative Colitis in Clinical Remission.
2021Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma.
2021Vavilovskii zhurnal genetiki i selektsii
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Patients With Inflammatory Bowel Disease Show IgG Immune Responses Towards Specific Intestinal Bacterial Genera.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Metabolites and Gut Microbes between Patients with Ulcerative Colitis and Healthy Individuals for an Integrative Medicine Approach to Ulcerative Colitis-A Pilot Observational Clinical Study (STROBE Compliant).
2022Diagnostics (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition and diverse differences of intestinal microbiota in ulcerative colitis patients.
2022Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Weighted Gene Co-Expression Network Analysis Identifies a Functional Guild and Metabolite Cluster Mediating the Relationship between Mucosal Inflammation and Adherence to the Mediterranean Diet in Ulcerative Colitis.
2023International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Baizhu-Baishao herb pair ameliorates functional constipation and intestinal microflora disorder in rats.
2023Animal models and experimental medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota signatures in inflammatory bowel disease.
2024United European gastroenterology journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Improvement of the inflammation-damaged intestinal barrier and modulation of the gut microbiota in ulcerative colitis after FMT in the SHIME® model.
2025BMC complementary medicine and therapies
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota-derived butyrate mediates the anticolitic effect of indigo supplementation through regulating CD4+ T cell differentiation.
2025iMeta
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Butylchlorogenate from Chaenomeles speciosa alleviates ulcerative colitis via suppressing NLRP3 inflammasome activation and remodeling intestinal homeostasis.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and metabolic signatures of anxiety in ulcerative colitis: a cross-sectional study.
2025Therapeutic advances in gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
17 papersComposition and function of the pediatric colonic mucosal microbiome in untreated patients with ulcerative colitis.
2016Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity.
2017Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Roseburia intestinalis supernatant ameliorates colitis induced in mice by regulating the immune response.
2019Molecular medicine reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Roseburia intestinalis‑derived flagellin ameliorates colitis by targeting miR‑223‑3p‑mediated activation of NLRP3 inflammasome and pyroptosis.
2020Molecular medicine reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota.
2021International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
New pathway ameliorating ulcerative colitis: focus on Roseburia intestinalis and the gut-brain axis.
2021Therapeutic advances in gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus rhamnosus from human breast milk ameliorates ulcerative colitis in mice via gut microbiota modulation.
2021Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of the Mucosa-Associated Microbiome Linked to the PTPN2 Risk Gene in Patients with Primary Sclerosing Cholangitis and Ulcerative Colitis.
2021Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The underlying mechanism of A-type procyanidins from peanut skin on DSS-induced ulcerative colitis mice by regulating gut microbiota and metabolism.
2022Journal of food biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Roseburia intestinalis and Its Metabolite Butyrate Inhibit Colitis and Upregulate TLR5 through the SP3 Signaling Pathway.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus plantarum ZJ316 alleviates ulcerative colitis by inhibiting inflammation and regulating short-chain fatty acid levels and the gut microbiota in a mouse model.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Faecalibacterium prausnitzii, Bacteroides faecis and Roseburia intestinalis attenuate clinical symptoms of experimental colitis by regulating Treg/Th17 cell balance and intestinal barrier integrity.
2023Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alterations in metabolome and microbiome: new clues on cathelicidin-related antimicrobial peptide alleviates acute ulcerative colitis.
2024Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota-mediated Alleviation of Dextran Sulfate Sodium-induced Colitis in Mice.
2024Gastro hep advances
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus fermentum 016 Alleviates Mice Colitis by Modulating Oxidative Stress, Gut Microbiota, and Microbial Metabolism.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota causally affects ulcerative colitis by potential mediation of plasma metabolites: A Mendelian randomization study.
2025Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
6 papersInfluence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention.
2017Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Healing from Within: How Gut Microbiota Predicts IBD Treatment Success-A Systematic Review.
2024International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease.
2025Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
Is the microbiome the answer to inflammatory bowel disease: systematic review.
2025Langenbeck's archives of surgery
Relevant review or meta-analysis for the signal-disease area.
Diet and Gut Microbiota in Inflammatory Bowel Disease: A Clinical and Nutritional Perspective.
2026Pharmaceuticals (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
The Structure-Decoding-Conversion-Effect Paradigm of Natural Polysaccharides for Gut Microbiota Remodeling in Ulcerative Colitis.
2026Nutrients
Relevant review or meta-analysis for the signal-disease area.