Gut Microbial Predictors of Type 2 Diabetes Remission Following Bariatric Surgery.
2020Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
supportedtopmoderate inflation risk
Roseburia
type 2 diabetes
Roseburia is an interesting but still moderate-confidence signal in type 2 diabetes.
Roseburia shows a moderate evidence base in type 2 diabetes, with multiple central papers and additional supporting literature.
roseburia
Credibility score
58
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 58Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- directionality and confounding still require curated review
Primary central evidence
13 papersMain gut bacterial composition differs between patients with type 1 and type 2 diabetes and non-diabetic adults.
2020Journal of diabetes and metabolic disorders
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Application of machine learning tools: Potential and useful approach for the prediction of type 2 diabetes mellitus based on the gut microbiome profile.
2022Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Cardiovascular Benefits of Empagliflozin Are Associated With Gut Microbiota and Plasma Metabolites in Type 2 Diabetes.
2022The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics and Clinical Significance of Intestinal Microbiota in Patients with Chronic Hepatitis B Cirrhosis and Type 2 Diabetes Mellitus.
2022Journal of diabetes research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiota in Patients with Diabetic Nephropathy.
2022Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the Gut Microbiota in Pregnant Women with Pregestational Type 2 Diabetes Mellitus.
2023mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enhanced trimethylamine metabolism and gut dysbiosis in type 2 diabetes mellitus with microalbumin.
2023Frontiers in endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolomics and Lipidomics Analyses Aid Model Classification of Type 2 Diabetes in Non-Human Primates.
2024Metabolites
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the Composition and Diversity of the Intestinal Microbiota Associated with Carbohydrate Consumption in Type 2 Diabetes Mellitus Patients.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Disorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis comorbid type 2 diabetes mellitus.
2025Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of the gut microbiota with type 2 diabetes: Links to disease and remission in the Japanese population.
2025Journal of diabetes investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Associated with Type 2 Diabetes and Dietary Balance in Older Adults: A Longitudinal Community-Based Cohort in China.
2026Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersCausal relationship between gut microbiota and type 2 diabetes: a two-sample Mendelian randomization study.
2023Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.
A specific gut microbiota signature is associated with an enhanced GLP-1 and GLP-2 secretion and improved metabolic control in patients with type 2 diabetes after metabolic Roux-en-Y gastric bypass.
2023Frontiers in endocrinology
Human primary paper with plausible association relevance to the disease context.
Association between gut microbiota and ultra-processed foods consumption among the patients with type 2 diabetes: a cross-sectional study.
2024Nutrition & metabolism
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
11 papersLactobacillus acidophilus alleviates type 2 diabetes by regulating hepatic glucose, lipid metabolism and gut microbiota in mice.
2019Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shenqi compound ameliorates type-2 diabetes mellitus by modulating the gut microbiota and metabolites.
2022Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Interrelations between Gut Microbiota Composition, Nutrient Intake and Diabetes Status in an Adult Japanese Population.
2022Journal of clinical medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ginsenoside Rg1 improved diabetes through regulating the intestinal microbiota in high-fat diet and streptozotocin-induced type 2 diabetes rats.
2022Journal of food biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Chinese medical nutrition therapy diet accompanied by intermittent energy restriction alleviates type 2 diabetes by enhancing pancreatic islet function and regulating gut microbiota composition.
2022Food research international (Ottawa, Ont.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A microbiome-targeting fibre-enriched nutritional formula is well tolerated and improves quality of life and haemoglobin A1c in type 2 diabetes: A double-blind, randomized, placebo-controlled trial.
2023Diabetes, obesity & metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lacticaseibacillus rhamnosus Hao9 exerts antidiabetic effects by regulating gut microbiome, glucagon metabolism, and insulin levels in type 2 diabetic mice.
2022Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mulberry leaf water extract alleviates type 2 diabetes in mice via modulating gut microbiota-host co-metabolism of branched-chain amino acid.
2023Phytotherapy research : PTR
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Low glycemic index potato biscuits alleviate physio-histological damage and gut dysbiosis in rats with type-2 diabetes mellitus induced by high-sugar and high-fat diet and streptozotocin.
2023The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Didang decoction improves gut microbiota and cognitive function in TDACD rats: Combined proteomics and 16S rRNA sequencing.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Twelve-Week Curcumin Supplementation Improves Glucose Homeostasis and Gut Health in Prediabetic Older Adults: A Pilot, Double-Blind, Placebo-Controlled Trial.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
19 papersMicrobiota and diabetes: an evolving relationship.
2014Gut
Relevant review or meta-analysis for the signal-disease area.
Roseburia spp.: a marker of health?
2017Future microbiology
Relevant review or meta-analysis for the signal-disease area.
Systematic review assessing the effectiveness of dietary intervention on gut microbiota in adults with type 2 diabetes.
2018Diabetologia
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.
2019Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Role of gut microbiota in type 2 diabetes pathophysiology.
2020EBioMedicine
Relevant review or meta-analysis for the signal-disease area.
Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species.
2021Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Dietary regulations for microbiota dysbiosis among post-menopausal women with type 2 diabetes.
2023Critical reviews in food science and nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Composition in Prediabetes and Newly Diagnosed Type 2 Diabetes: A Systematic Review of Observational Studies.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Prebiotics Progress Shifts in the Intestinal Microbiome That Benefits Patients with Type 2 Diabetes Mellitus.
2023Biomolecules
Relevant review or meta-analysis for the signal-disease area.
Unravelling the Crosstalk between Estrogen Deficiency and Gut-biotaDysbiosis in the Development of Diabetes Mellitus.
2024Current diabetes reviews
Relevant review or meta-analysis for the signal-disease area.
Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics.
2024Probiotics and antimicrobial proteins
Relevant review or meta-analysis for the signal-disease area.
Harnessing Prebiotics to Improve Type 2 Diabetes Outcomes.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
A systematic review on gut microbiota in type 2 diabetes mellitus.
2024Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.
Effects of Nut Intake on Gut Microbiome Composition and Gut Function in Adults: A Systematic Review and Meta-analysis.
2025Advances in nutrition (Bethesda, Md.)
Relevant review or meta-analysis for the signal-disease area.
Exercise-induced modulation of gut microbiota in individuals with obesity and type 2 diabetes: a systematic review and meta-analysis.
2025Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiota-Metabolic Axis: Emerging Insights from Human and Experimental Studies on Type 2 Diabetes Mellitus-A Narrative Review.
2025Medicina (Kaunas, Lithuania)
Relevant review or meta-analysis for the signal-disease area.
The Gut Nexus: Unraveling Microbiota-Mediated Links Between Type 2 Diabetes and Colorectal Cancer.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.
Mediterranean diet, gut microbiota, and type 2 diabetes: A systematic review and meta-analysis of intervention trials.
2026Nutrition, metabolism, and cardiovascular diseases : NMCD
Relevant review or meta-analysis for the signal-disease area.