sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Roseburia
obesity
Roseburia looks like a credible signal in obesity, though some caution is still warranted.
Roseburia shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
roseburia
Credibility score
68
Human translation
4/5
Reproducibility
4/5
Novelty
2/5
Actionability
3/5
Credibility 68Human translation 4/5Reproducibility 4/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
20 papersDiscrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
2019Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exercise training modulates the gut microbiota profile and impairs inflammatory signaling pathways in obese children.
2020Experimental & molecular medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-Term Vegan Meditation Improved Human Gut Microbiota.
2020Evidence-based complementary and alternative medicine : eCAM
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metformin Affects Gut Microbiome Composition and Function and Circulating Short-Chain Fatty Acids: A Randomized Trial.
2021Diabetes care
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Machine learning-based investigation of the relationship between gut microbiome and obesity status.
2022Microbes and infection
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial co-occurrence complicates associations of gut microbiome with US immigration, dietary intake and obesity.
2021Genome biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome Associated to Methane Metabolism in Mexican Children with Obesity.
2022Children (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Low-Carbohydrate Diet and Exercise Training on Gut Microbiota.
2022Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of intestinal microbiota in normal weight and overweight Border Collie and Labrador Retriever dogs.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Polyclonal Aptamer Library for the Specific Binding of the Gut Bacterium Roseburia intestinalis in Mixtures with Other Gut Microbiome Bacteria and Human Stool Samples.
2022International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Key Stratification of Microbiota Taxa and Metabolites in the Host Metabolic Health-Disease Balance.
2023International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Duodenal microbiota and weight-loss following sleeve gastrectomy and Roux-en-Y gastric bypass - a pilot study.
2023BMC surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Liver Bacterial Colonization in Patients with Obesity and Gut Dysbiosis.
2024Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Recipient microbiome-related features predicting metabolic improvement following fecal microbiota transplantation in adults with severe obesity and metabolic syndrome: a secondary analysis of a phase 2 clinical trial.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary Antrodia cinnamomea Polysaccharide Intervention Modulates Clinical Symptoms by Regulating Ovarian Metabolites and Restructuring the Intestinal Microbiota in Rats with Letrozole-Induced PCOS.
2024Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An Analysis of the Digestive and Reproductive Tract Microbiota in Infertile Women with Obesity.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Role of Increasing Body Mass Index in Gut Barrier Dysfunction, Systemic Inflammation, and Metabolic Dysregulation in Obesity.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Influence of taste and smell perception on weight loss induced by sleeve gastrectomy and its association with gut microbiota.
2025Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Postnatal overfeeding induces gut microbiota disturbances and impairs GPR43/FIAF/LPL pathway in the rat model of PCOS.
2025Journal of physiology and biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
8 papersAltered Gut Microbiota Composition Is Associated With Back Pain in Overweight and Obese Individuals.
2020Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota-mediated xanthine metabolism is associated with resistance to high-fat diet-induced obesity.
2021The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Konjaku Flour on the Gut Microbiota of Obese Patients.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrated Microbiome and Metabolome Analysis Reveals Hypothalamic-Comorbidities Related Signatures in Craniopharyngioma.
2024Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Roseburia hominis improves host metabolism in diet-induced obesity.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Three Kampo medicines-bofutsushosan, boiogito, and daisaikoto-have different effects on host fat accumulation and the intestinal microbiota in a high-fat-diet-induced mouse model of obesity.
2025Journal of natural medicines
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Postbiotic potential of SCFAs on metaflammation and gut microbiota alteration in diabetes.
2025Journal of biosciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Twelve-Week Curcumin Supplementation Improves Glucose Homeostasis and Gut Health in Prediabetic Older Adults: A Pilot, Double-Blind, Placebo-Controlled Trial.
2025Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
18 papersBifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.
2016Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease.
2018Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Dysbiosis in Human Obesity: Impact of Bariatric Surgery.
2019Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Gallstone Disease, Obesity and the Firmicutes/Bacteroidetes Ratio as a Possible Biomarker of Gut Dysbiosis.
2020Journal of personalized medicine
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.
2021Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
Dietary regulations for microbiota dysbiosis among post-menopausal women with type 2 diabetes.
2023Critical reviews in food science and nutrition
Relevant review or meta-analysis for the signal-disease area.
Probiotics in the Prevention and Treatment of Gestational Diabetes Mellitus (GDM): A Review.
2022Nutrients
Relevant review or meta-analysis for the signal-disease area.
Contribution of the microbiome for better phenotyping of people living with obesity.
2023Reviews in endocrine & metabolic disorders
Relevant review or meta-analysis for the signal-disease area.
Anaerobes in specific infectious and noninfectious diseases: new developments.
2023Anaerobe
Relevant review or meta-analysis for the signal-disease area.
The Interplay between Medical Plants and Gut Microbiota in Cancer.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
The association of infant and mother gut microbiomes with development of allergic diseases in children: a systematic review.
2024The Journal of asthma : official journal of the Association for the Care of Asthma
Relevant review or meta-analysis for the signal-disease area.
Gut Microbes in Polycystic Ovary Syndrome and Associated Comorbidities; Type 2 Diabetes, Non-Alcoholic Fatty Liver Disease (NAFLD), Cardiovascular Disease (CVD), and the Potential of Microbial Therapeutics.
2024Probiotics and antimicrobial proteins
Relevant review or meta-analysis for the signal-disease area.
How important are fatty acids in human health and can they be used in treating diseases?
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Modulation Through Mediterranean Diet Foods: Implications for Human Health.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.
Precocious puberty and gut microbiome: a systematic review and meta-analysis.
2025Pediatric research
Relevant review or meta-analysis for the signal-disease area.
Exercise reshapes gut microbiota to ameliorate core symptoms in PCOS: molecular mechanisms and therapeutic implications.
2025Frontiers in endocrinology
Relevant review or meta-analysis for the signal-disease area.