Gut Microbial Diversity Is Reduced in Smokers with Crohn's Disease.
2016Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Richness
crohn's disease
Richness looks like a credible signal in crohn's disease, though some caution is still warranted.
Richness shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
richness
Credibility score
67
Human translation
4/5
Reproducibility
4/5
Novelty
2/5
Actionability
4/5
Credibility 67Human translation 4/5Reproducibility 4/5Novelty 2/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Primary central evidence
20 papersFecal microbial dysbiosis in Chinese patients with inflammatory bowel disease.
2018World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Individualized Dynamics in the Gut Microbiota Precede Crohn's Disease Flares.
2019The American journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of mucosa-associated gut microbiota during treatment in Crohn's disease.
2019World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Whole-Virome Analysis Sheds Light on Viral Dark Matter in Inflammatory Bowel Disease.
2019Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal and mucosal microbiota profiling in pediatric inflammatory bowel diseases.
2021European journal of gastroenterology & hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota profile in patients with inflammatory bowel disease in Taiwan.
2021Journal of the Chinese Medical Association : JCMA
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-omics reveal microbial determinants impacting responses to biologic therapies in inflammatory bowel disease.
2021Cell host & microbe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Profiling of Fecal-Derived Bacterial Membrane Vesicles in Crohn's Disease Patients.
2021Cells
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Features of the gut prokaryotic virome of Japanese patients with Crohn's disease.
2022Journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota analyses of inflammatory bowel diseases from a representative Saudi population.
2023BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Bile Acid and Pouch Microbiota Composition in Patients With Chronic Pouchitis.
2024Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal microbiome of surgically treated terminal ileal Crohn's disease.
2023Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Reverse-engineered exclusive enteral nutrition in pediatric Crohn's disease: A pilot trial.
2024Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Inflammatory bowel disease associated with primary sclerosing cholangitis is associated with an altered gut microbiome and bile acid profile.
2024Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the salivary microbiome of adults with inflammatory bowel disease.
2025Journal of oral microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal biomarkers, microbiota composition, and genetic predisposition to inflammatory bowel disease as predictors of Parkinson's disease manifestation.
2025Journal of Parkinson's disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The intestinal mucosa-associated microbiota in IBD-associated arthritis displays lower relative abundance of Roseburia intestinalis.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Whole Food Diet Induces Remission in Children and Young Adults With Mild to Moderate Crohn's Disease and Is More Tolerable Than Exclusive Enteral Nutrition: A Randomized Controlled Trial.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Mycobiota in Patients with Inflammatory Bowel Diseases and Extraintestinal Manifestations.
2024Gut microbes reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersFailure of colonization following gut microbiota transfer exacerbates DSS-induced colitis.
2024bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.
Preclinical supporting evidence
9 papersIncreased abundance of proteobacteria in aggressive Crohn's disease seven years after diagnosis.
2019Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Melatonin Mitigates Oxazolone-Induced Colitis in Microbiota-Dependent Manner.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative analysis of gut microbiota in healthy and diarrheic yaks.
2022Microbial cell factories
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Coptis chinensis and Berberine Ameliorate Chronic Ulcerative Colitis: An Integrated Microbiome-Metabolomics Study.
2023The American journal of Chinese medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Phylogeny and disease associations of a widespread and ancient intestinal bacteriophage lineage.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages.
2024Biochimica et biophysica acta. Molecular basis of disease
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Failure of colonization following gut microbiota transfer exacerbates DSS-induced colitis.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galactooligosaccharides Promote Gut Barrier Integrity and Exert Anti-Inflammatory Effects in DSS-Induced Colitis Through Microbiota Modulation.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cytochrome P450 Cyp2s1 regulation of the intestinal metabolome and microbiome.
2026Mucosal immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
16 papersEpidemiologic clues to inflammatory bowel disease.
2010Current gastroenterology reports
Relevant review or meta-analysis for the signal-disease area.
Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases?
2013Best practice & research. Clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Suppression of inflammation by helminths: a role for the gut microbiota?
2015Philosophical transactions of the Royal Society of London. Series B, Biological sciences
Relevant review or meta-analysis for the signal-disease area.
Stable core virome despite variable microbiome after fecal transfer.
2017Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Diet and Gut Microbiota in Health and Disease.
2017Nestle Nutrition Institute workshop series
Relevant review or meta-analysis for the signal-disease area.
Review article: the gut microbiome in inflammatory bowel disease-avenues for microbial management.
2018Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Urbanization and the gut microbiota in health and inflammatory bowel disease.
2018Nature reviews. Gastroenterology & hepatology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome in Inflammatory Bowel Disease and Other Chronic Immune-Mediated Inflammatory Diseases.
2017Inflammatory intestinal diseases
Relevant review or meta-analysis for the signal-disease area.
Homeostasis and dysbiosis of the gut microbiome in health and disease.
2019Journal of biosciences
Relevant review or meta-analysis for the signal-disease area.
Whole Food-Based Approaches to Modulating Gut Microbiota and Associated Diseases.
2020Annual review of food science and technology
Relevant review or meta-analysis for the signal-disease area.
Association between antibiotics and gut microbiome dysbiosis in children: systematic review and meta-analysis.
2021Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Microbiota and Drug Response in Inflammatory Bowel Disease.
2021Pathogens (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Systematic Review: The Gut Microbiome and Its Potential Clinical Application in Inflammatory Bowel Disease.
2021Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Assessing the Relationship between the Gut Microbiota and Inflammatory Bowel Disease Therapeutics: A Systematic Review.
2023Pathogens (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome, metabolome, host immunity associated with inflammatory bowel disease and intervention of fecal microbiota transplantation.
2023Journal of autoimmunity
Relevant review or meta-analysis for the signal-disease area.
Modeling microbiota-associated human diseases: from minimal models to complex systems.
2022Microbiome research reports
Relevant review or meta-analysis for the signal-disease area.