sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Richness
colorectal cancer
Richness looks like a credible signal in colorectal cancer, though some caution is still warranted.
Richness shows a strong literature footprint in colorectal cancer, with substantial central evidence and broader supporting literature.
richness
Credibility score
77
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 77Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
25 papersThe Role of Curcumin in Modulating Colonic Microbiota During Colitis and Colon Cancer Prevention.
2015Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Nutritional Correlates of Human Oral Microbiome.
2017Journal of the American College of Nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tissue-Associated Bacterial Alterations in Rectal Carcinoma Patients Revealed by 16S rRNA Community Profiling.
2016Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of ursodeoxycholic acid on the gut microbiome and colorectal adenoma development.
2019Cancer medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Biodiversity and richness shifts of mucosa-associated gut microbiota with progression of colorectal cancer.
2020Research in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Study of the Relationship between Microbiome and Colorectal Cancer Susceptibility Using 16SrRNA Sequencing.
2020BioMed research international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota-Mediated Inflammation and Gut Permeability in Patients with Obesity and Colorectal Cancer.
2020International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The aging-related risk signature in colorectal cancer.
2021Aging
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota changes with fermented kimchi intake regulated either formation or advancement of colon adenoma.
2021Journal of clinical biochemistry and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Potential of fecal microbiota for detection and postoperative surveillance of colorectal cancer.
2021BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and Fecal Metabolome in Colorectal Cancer: Implication of Intestinal Metabolism for Tumorigenesis.
2022Frontiers in physiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in co-abundant bacteriome in colorectal cancer and its persistence after surgery: a pilot study.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A transformation perspective on marginal and conditional models.
2024Biostatistics (Oxford, England)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prediction model of colorectal cancer (CRC) lymph node metastasis based on intestinal bacteria.
2023Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Levels of systemic inflammation response index are correlated with tumor-associated bacteria in colorectal cancer.
2023Cell death & disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome associated with low anterior resection syndrome after rectal cancer surgery.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Salivary and fecal microbiota: potential new biomarkers for early screening of colorectal polyps.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Identification of taxonomic changes in the fecal bacteriome associated with colorectal polyps and cancer: potential biomarkers for early diagnosis.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tumor-associated microbiome features of metastatic colorectal cancer and clinical implications.
2023Frontiers in oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of differences in intestinal flora associated with different BMI status in colorectal cancer patients.
2024Journal of translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Geographical association of biodiversity with cancer and cardiovascular mortality rates: analysis of 39 distinct conditions.
2024Frontiers in public health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in Intestinal Microbiota and Their Relationship With Patient Characteristics in Colorectal Cancer.
2024Clinical Medicine Insights. Oncology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and plasma metabolome alterations in ileostomy and after closure of ileostomy.
2025Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered microbiota of rectal mucosa in rectal cancer patients.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tumor-resident Malassezia can promote hepatocellular carcinoma development by downregulating bile acid synthesis and modulating tumor microenvironment.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
14 papersDifferences in microbial signatures between rectal mucosal biopsies and rectal swabs.
2012Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The gut microbiota in conventional and serrated precursors of colorectal cancer.
2016Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gavage of Fecal Samples From Patients With Colorectal Cancer Promotes Intestinal Carcinogenesis in Germ-Free and Conventional Mice.
2017Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Zerumbone Restores Gut Microbiota Composition in ETBF Colonized AOM/DSS Mice.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prebiotics-Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer.
2020Advanced materials (Deerfield Beach, Fla.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vitamin E delta-tocotrienol and metabolite 13'-carboxychromanol inhibit colitis-associated colon tumorigenesis and modulate gut microbiota in mice.
2021The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Dysbiosis and Abnormal Bile Acid Metabolism in Colitis-Associated Cancer.
2021Gastroenterology research and practice
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of Gut Microbiota Combined with Upregulation of Intestinal Tight Junction Explains Anti-Inflammatory Effect of Corylin on Colitis-Associated Cancer in Mice.
2022International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Berberine inhibits intestinal carcinogenesis by suppressing intestinal pro-inflammatory genes and oncogenic factors through modulating gut microbiota.
2022BMC cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut bacteria influence Blastocystis sp. phenotypes and may trigger pathogenicity.
2023PLoS neglected tropical diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of fecal microbiota transplantation combined with selenium on intestinal microbiota in mice with colorectal cancer.
2024Biochemical and biophysical research communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alteration of ascending colon mucosal microbiota in patients after cholecystectomy.
2024World journal of gastrointestinal surgery
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Curcumin suppresses colorectal tumorigenesis through restoring the gut microbiota and metabolites.
2024BMC cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Role of aspirin on colorectal cancer risk and bacterial translocation to bloodstream.
2025PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
11 papersDiet and microbiota linked in health and disease.
2018Food & function
Relevant review or meta-analysis for the signal-disease area.
Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice.
2018World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Impact of microbiota in colorectal carcinogenesis: lessons from experimental models.
2018Intestinal research
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans.
2018World journal of gastrointestinal pathophysiology
Relevant review or meta-analysis for the signal-disease area.
Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.
2019Nature medicine
Relevant review or meta-analysis for the signal-disease area.
Mycobiome and Cancer: What Is the Evidence?
2021Cancers
Relevant review or meta-analysis for the signal-disease area.
Microbiota and Colorectal Cancer: From Gut to Bedside.
2021Frontiers in pharmacology
Relevant review or meta-analysis for the signal-disease area.
A Scoping Review Evaluating the Current State of Gut Microbiota Research in Africa.
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Modeling microbiota-associated human diseases: from minimal models to complex systems.
2022Microbiome research reports
Relevant review or meta-analysis for the signal-disease area.
Microbiota composition effect on immunotherapy outcomes in colorectal cancer patients: A systematic review.
2024PloS one
Relevant review or meta-analysis for the signal-disease area.
Impact of metallic nanoparticles on gut microbiota modulation in colorectal cancer: A review.
2024Cancer innovation
Relevant review or meta-analysis for the signal-disease area.