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Richness

autism

Richness is an interesting but still moderate-confidence signal in autism.

Richness shows a strong literature footprint in autism, with substantial central evidence and broader supporting literature.

richness
Credibility score
53
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
4/5
Credibility 53Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 4/5
Why this scores the way it does
  • strong central evidence base
  • substantial preclinical support
Main caveats
  • retrieval noise or disease-specificity issues may remain

Primary central evidence

16 papers
The valproic acid rat model of autism presents with gut bacterial dysbiosis similar to that in human autism.
2018
Molecular autism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota in Chinese Children With Autism Spectrum Disorders.
2019
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Dysbiosis Associated With Altered Production of Short Chain Fatty Acids in Children With Neurodevelopmental Disorders.
2020
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota changes in patients with autism spectrum disorders.
2020
Journal of psychiatric research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Underdevelopment of the gut microbiota and bacteria species as non-invasive markers of prediction in children with autism spectrum disorder.
2022
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation among gut microbiota, fecal metabolites and autism-like behavior in an adolescent valproic acid-induced rat autism model.
2022
Behavioural brain research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evidence for long-lasting alterations in the fecal microbiota following prenatal alcohol exposure.
2022
Alcoholism, clinical and experimental research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes to the Gut Microbiome in Young Children Showing Early Behavioral Signs of Autism.
2022
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered gut microbiota correlates with behavioral problems but not gastrointestinal symptoms in individuals with autism.
2022
Brain, behavior, and immunity
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiome and serum amino acid metabolome alterations in autism spectrum disorder.
2024
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Absence of association between maternal adverse events and long-term gut microbiome outcomes in the Australian autism biobank.
2024
Brain, behavior, & immunity - health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study.
2024
Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomics Study Suggests the Role of Vitamins and Gut Microbiome in Autism Spectrum Disorder.
2025
Digestion
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comprehensive analysis of gut microbiota and fecal metabolites in patients with autism spectrum disorder.
2025
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in children and adolescents with autism, ADHD and anorexia nervosa, and its link to the levels of satiety hormones.
2025
Neuroscience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic Characterization of Gut Microbiota in Children with Autism Spectrum Disorder: Microbial Signatures and Modulation by Anti-Inflammatory Diet and Probiotics.
2025
Pharmaceuticals (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Supplementation with a Limosilactobacillus fermentum K73 synbiotic modulates gut microbiota function and behavior in gnotobiotic mice transplanted with microbiota from children diagnosed with autism spectrum disorder.
2025
bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.

Preclinical supporting evidence

15 papers
Analysis of the Duodenal Microbiome in Autistic Individuals: Association With Carbohydrate Digestion.
2017
Journal of pediatric gastroenterology and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Adaptation to different communicative contexts: an eye tracking study of autistic adults.
2019
Journal of neurodevelopmental disorders
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Single Volume Image Generator and Deep Learning-Based ASD Classification.
2020
IEEE journal of biomedical and health informatics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Episodic Future Thinking in Autism Spectrum Disorder and 22q11.2 Deletion Syndrome: Association with Anticipatory Pleasure and Social Functioning.
2021
Journal of autism and developmental disorders
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tongue microbiome in children with autism spectrum disorder.
2021
Journal of oral microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Neurodevelopmental Trajectories and Clinical Profiles in a Sample of Children and Adolescents With Early- and Very-Early-Onset Schizophrenia.
2021
Frontiers in psychiatry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of metformin in autistic BTBR T + Itpr3tf/J mice administered a high-fat diet.
2022
Brain research bulletin
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Selective Probiotic Treatment Positively Modulates the Microbiota-Gut-Brain Axis in the BTBR Mouse Model of Autism.
2022
Brain sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bringing the autistic lifeworld to supportive technology design: an enactive approach.
2024
CoDesign : international journal of cocreation in design and the arts
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Social attention in the wild - fixations to the eyes and autistic traits during a naturalistic interaction in a healthy sample.
2024
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterization of gut microbiota on gender and age groups bias in Thai patients with autism spectrum disorder.
2025
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions.
2025
Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Potential association between altered oral microbiota and oxidative stress in individuals with autism.
2025
Autism : the international journal of research and practice
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Porphyromonas gingivalis deteriorates autism spectrum disorders by disturbing the gut and oral microbiota.
2025
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Lactobacillus Acidophilus Mediated Improvement of Intestinal Barrier in Mice with Autism.
2025
Probiotics and antimicrobial proteins
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

9 papers
A genomic view on epilepsy and autism candidate genes.
2016
Genomics
Relevant review or meta-analysis for the signal-disease area.
Analyzing the FFR: A tutorial for decoding the richness of auditory function.
2019
Hearing research
Relevant review or meta-analysis for the signal-disease area.
Social cognition in context: A naturalistic imaging approach.
2020
NeuroImage
Relevant review or meta-analysis for the signal-disease area.
Institutional analysis in scientific health production: an integrative literature review.
2020
Revista da Escola de Enfermagem da U S P
Relevant review or meta-analysis for the signal-disease area.
Towards equitable diagnoses for autism and attention-deficit/hyperactivity disorder across sexes and genders.
2022
Current opinion in psychiatry
Relevant review or meta-analysis for the signal-disease area.
Neurophysiological measures and correlates of cognitive load in attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and dyslexia: A scoping review and research recommendations.
2024
The European journal of neuroscience
Relevant review or meta-analysis for the signal-disease area.
A matter of time: Developmental cascades for developmental science.
2025
Infant behavior & development
Relevant review or meta-analysis for the signal-disease area.
OUTCOMES IN MACHINE LEARNING MODELS FOR CHILD PSYCHIATRY: A SYSTEMATIC REVIEW OF THE LITERATURE.
2025
Psychiatria Danubina
Relevant review or meta-analysis for the signal-disease area.
[Autism and inter-subjectivity].
1998
Actas luso-espanolas de neurologia, psiquiatria y ciencias afines
Relevant review or meta-analysis for the signal-disease area.