preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Richness
atopic dermatitis
Richness has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Richness shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
richness
Credibility score
34
Human translation
2/5
Reproducibility
3/5
Novelty
4/5
Actionability
2/5
Credibility 34Human translation 2/5Reproducibility 3/5Novelty 4/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
6 papersAtopic dermatitis microbiomes stratify into ecologic dermotypes enabling microbial virulence and disease severity.
2021The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China.
2021Journal of asthma and allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in Gut Microbiota of Patients with Atopic Dermatitis During Balneotherapy.
2022Clinical, cosmetic and investigational dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study.
2022Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dupilumab-associated ocular surface disease is characterized by a shift from Th2/Th17 toward Th1/Th17 inflammation.
2024Allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Study on the characteristics and differences of intestinal microbiota in children with allergic diseases].
2026Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
5 papersMicrobial community profiling shows dysbiosis in the lesional skin of Vitiligo subjects.
2016Scientific reports
Human primary paper with plausible association relevance to the disease context.
Identification of cutaneous fungi and mites in adult atopic dermatitis: analysis by targeted 18S rRNA amplicon sequencing.
2021BMC microbiology
Human primary paper with plausible association relevance to the disease context.
Differences in the skin microbial community between patients with active and stable vitiligo based on 16S rRNA gene sequencing.
2021The Australasian journal of dermatology
Human primary paper with plausible association relevance to the disease context.
Longitudinal disease-associated gut microbiome differences in infants with food protein-induced allergic proctocolitis.
2022Microbiome
Human primary paper with plausible association relevance to the disease context.
Multi-omics analyses reveal interactions between the skin microbiota and skin metabolites in atopic dermatitis.
2024Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
19 papersThe skin microbiome of caspase-14-deficient mice shows mild dysbiosis.
2014Experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Investigation of the skin microbiome: swabs vs. biopsies.
2019The British journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Psychosocial Impact of Atopic Dermatitis in Adults: A Qualitative Study.
2020Actas dermo-sifiliograficas
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparing DADA2 and OTU clustering approaches in studying the bacterial communities of atopic dermatitis.
2020Journal of medical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Probiotic baths for atopic dermatitis].
2021Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Description and comparison of the skin and ear canal microbiota of non-allergic and allergic German shepherd dogs using next generation sequencing.
2021PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial dysbiosis in a mouse model of atopic dermatitis mimics shifts in human microbiome and correlates with the key pro-inflammatory cytokines IL-4, IL-33 and TSLP.
2022Journal of the European Academy of Dermatology and Venereology : JEADV
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Skin and Nose Microbiome and Its Association with Filaggrin Gene Mutations in Pediatric Atopic Dermatitis.
2022Dermatology (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Exploring the Differences in the Gut Microbiome in Atopic Dermatitis According to the Presence of Gastrointestinal Symptoms.
2022Journal of clinical medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered Maturation of the Skin Microbiome in Infants with Atopic Dermatitis.
2022Acta dermato-venereologica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin microbiome and its association with host cofactors in determining atopic dermatitis severity.
2023Journal of the European Academy of Dermatology and Venereology : JEADV
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cutaneous dysbiosis may amplify barrier dysfunction in patients with atopic dermatitis.
2022Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Increased risk of osteoarthritis in patients with atopic disease.
2023Annals of the rheumatic diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A simplified bacterial community found within the epidermis than at the epidermal surface of atopic dermatitis patients and healthy controls.
2023BMC microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pinewood VOC emissions protect from oxazolone-induced inflammation and dysbiosis in a mouse model of atopic dermatitis.
2024Environment international
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects on the Skin Microbiome by a Moisturizer Formulated for Eczema-Prone and Sensitive Skin.
2025Journal of drugs in dermatology : JDD
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Resilience of the Skin Microbiome in Atopic Dermatitis During Short-Term Topical Treatment.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Facial Skin Mycobiome in Atopic Dermatitis With and Without Facial Involvement and Healthy Controls: A Case-Control Study.
2026Experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Preliminary Characterization of Skin Microbiota and Mycobiota in Atopic Dermatitis by Metagenomic and Culture-Based Analyses.
2026Life (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersDemystifying Dysbiosis: Can the Gut Microbiome Promote Oral Tolerance Over IgE-mediated Food Allergy?
2018Current pediatric reviews
Relevant review or meta-analysis for the signal-disease area.
The development of human gut microbiota fermentation capacity during the first year of life.
2022Microbial biotechnology
Relevant review or meta-analysis for the signal-disease area.
Fruit vinegar as a promising source of natural anti-inflammatory agents: an up-to-date review.
2024Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
Relevant review or meta-analysis for the signal-disease area.
Advances in research on gut microbiota and allergic diseases in children.
2025Current research in microbial sciences
Relevant review or meta-analysis for the signal-disease area.