preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Proteobacteria
ulcerative colitis
Proteobacteria has meaningful literature visibility in ulcerative colitis, but the current evidence mix suggests a substantial risk of overclaiming.
Proteobacteria shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.
proteobacteria
Credibility score
98
Human translation
2/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 98Human translation 2/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
2 flagssparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
Primary central evidence
26 papersDifferences between tissue-associated intestinal microfloras of patients with Crohn's disease and ulcerative colitis.
2006Journal of clinical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sulphate-reducing bacteria from ulcerative colitis patients induce apoptosis of gastrointestinal epithelial cells.
2017Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The possible relationship between Campylobacter spp./Arcobacter spp. and patients with ulcerative colitis.
2018European journal of gastroenterology & hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The prevalence and transcriptional activity of the mucosal microbiota of ulcerative colitis patients.
2018Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal 5-aminosalicylic acid concentration, drug formulation and mucosal microbiome in patients with quiescent ulcerative colitis.
2019Alimentary pharmacology & therapeutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Markers of dysbiosis in patients with ulcerative colitis and Crohn's disease.
2019Terapevticheskii arkhiv
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Serum Biomarkers Identify Patients Who Will Develop Inflammatory Bowel Diseases Up to 5 Years Before Diagnosis.
2020Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adsorptive granulomonocytapheresis alters the gut bacterial microbiota in patients with active ulcerative colitis.
2021Journal of clinical apheresis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Features of the gut microbiota in ulcerative colitis patients with depression: A pilot study.
2021Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Fecal microbiome change in patients with ulcerative colitis after fecal microbiota transplantation].
2020Vavilovskii zhurnal genetiki i selektsii
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clinical effects of ursodeoxycholic acid on patients with ulcerative colitis may improve via the regulation of IL-23-IL-17 axis and the changes of the proportion of intestinal microflora.
2021Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut dysbiosis and clinical phases of pancolitis in patients with ulcerative colitis.
2021MicrobiologyOpen
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis.
2021World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Epidemiology of Helicobacter pylori.
2022Alimentary pharmacology & therapeutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma.
2021Vavilovskii zhurnal genetiki i selektsii
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Metabolite Changes in Patients With Ulcerative Colitis and Clostridioides difficile Infection.
2022Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gastrointestinal health: changes of intestinal mucosa and microbiota in patients with ulcerative colitis and irritable bowel syndrome from PM2.5-polluted regions of Ukraine.
2023Environmental science and pollution research international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition and diverse differences of intestinal microbiota in ulcerative colitis patients.
2022Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Overrepresentation of Enterobacteriaceae and Escherichia coli is the major gut microbiome signature in Crohn's disease and ulcerative colitis; a comprehensive metagenomic analysis of IBDMDB datasets.
2022Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Signatures Are Associated With Psychopathological Profiles in Patients With Ulcerative Colitis: Results From an Italian Tertiary IBD Center.
2023Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in gut microbiota and fecal bile acids between Caucasian and Hispanic children and young adults with ulcerative colitis.
2023Physiological reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparative Study of Intestinal Microbiome in Patients with Ulcerative Colitis and Healthy Controls in Korea.
2023Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Clinical features and fecal microbiota characteristics of patients with both ulcerative colitis and axial spondyloarthritis.
2024BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differentiated approach to management of patients with irritable bowel syndrome and ulcerative colitis in non-alcoholic fatty liver disease.
2024Wiadomosci lekarskie (Warsaw, Poland : 1960)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Structural Variations in Ulcerative Colitis-associated Escherichia coli Reduce Fructose Utilization and Aggravate Inflammation Under High-Fructose Diet.
2025Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predictive Microbial Markers Distinguish Responders and Non-Responders to Adalimumab: A Step Toward Precision Medicine in Ulcerative Colitis.
2025Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
45 papersSmoking, humoral immunity, and ulcerative colitis.
1991Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Twin study indicates loss of interaction between microbiota and mucosa of patients with ulcerative colitis.
2011Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Human Mesenteric Lymph Node Microbiome Differentiates Between Crohn's Disease and Ulcerative Colitis.
2019Journal of Crohn's & colitis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut pathobionts underlie intestinal barrier dysfunction and liver T helper 17 cell immune response in primary sclerosing cholangitis.
2019Nature microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fecal Microbiota Transplantation (FMT) Alleviates Experimental Colitis in Mice by Gut Microbiota Regulation.
2020Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Scutellaria baicalensis Georgi polysaccharide ameliorates DSS-induced ulcerative colitis by improving intestinal barrier function and modulating gut microbiota.
2021International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiosis of gut microbiota in Polish patients with ulcerative colitis: a pilot study.
2021Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kaempferol Alleviates Murine Experimental Colitis by Restoring Gut Microbiota and Inhibiting the LPS-TLR4-NF-κB Axis.
2021Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Evidence for the butyrate metabolism as key pathway improving ulcerative colitis in both pediatric and adult patients.
2021Bioengineered
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
2022Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
2022Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation.
2022Cell
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Molecular detection of pathogenic bacteria in the colonic biopsies from patients with Ulcerative Colitis.
2022African health sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Additive effect of probiotics (Mutaflor) on 5-aminosalicylic acid therapy in patients with ulcerative colitis.
2022The Korean journal of internal medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect and Mechanism of Pharmaceutical Excipients on Berberine to Alleviate Ulcerative Colitis via Regulating Gut Microbiota.
2022Molecules (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Jatrorrhizine alleviates ulcerative colitis via regulating gut microbiota and NOS2 expression.
2022Gut pathogens
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Houttuynia cordata polysaccharides alleviate ulcerative colitis by restoring intestinal homeostasis.
2022Chinese journal of natural medicines
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sauchinone alleviates dextran sulfate sodium-induced ulcerative colitis via NAD(P)H dehydrogenase [quinone] 1/NF-kB pathway and gut microbiota.
2022Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shikimic Acid Regulates the NF-κB/MAPK Signaling Pathway and Gut Microbiota to Ameliorate DSS-Induced Ulcerative Colitis.
2023Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
GPR35-mediated kynurenic acid sensing contributes to maintenance of gut microbiota homeostasis in ulcerative colitis.
2023FEBS open bio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis.
2023Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Association between dietary acid load and the odds of ulcerative colitis: a case-control study.
2023Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Altered metabolome and microbiome features provide clues in predicting recurrence of ulcerative colitis.
2024Journal of pharmaceutical and biomedical analysis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Desulfovibrio vulgaris interacts with novel gut epithelial immune receptor LRRC19 and exacerbates colitis.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota.
2024Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polyphenol Extracts from Ziziphus jujuba Mill. "Junzao" Attenuates Ulcerative Colitis by Inhibiting the NLRP3 and MAPKs Signaling Pathways and Regulating Gut Microbiota Homeostasis in Mice.
2024Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Clinical characteristics of ulcerative colitis patients with different types of Helicobacter pylori infection.
2024Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
New insights into the interactions between the gut microbiota and the inflammatory response to ulcerative colitis in a mouse model of dextran sodium sulfate and possible mechanisms of action for treatment with PE&AFWE.
2024Animal models and experimental medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Hesperetin Alleviated Experimental Colitis via Regulating Ferroptosis and Gut Microbiota.
2024Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multi-biome analysis identifies distinct gut microbial signatures and their crosstalk in ulcerative colitis and Crohn's disease.
2024Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sustained in situ protein production and release in the mammalian gut by an engineered bacteriophage.
2026Nature biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Angelicone Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota.
2025Planta medica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Goat Milk-Derived Extracellular Vesicles Alleviate Colitis Potentially Through Improved Gut Microbiota in Mice.
2025Foods (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Plantamajoside alleviates DSS-induced ulcerative colitis by modulating gut microbiota, upregulating CBS, and inhibiting NF-κB.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Synergistic Genetic and Chemical Engineering of Probiotics for Enhanced Intestinal Microbiota Regulation and Ulcerative Colitis Treatment.
2025Advanced materials (Deerfield Beach, Fla.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Biosynthesis of Melanin with Engineered Probiotics for Oral Treatment of Ulcerative Colitis.
2025ACS nano
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Novel Small-Molecule miR-124 Inducer Acts as "a Physiological Brake" of Inflammation in Ulcerative Colitis by Targeting the PIK3R2/PI3K/Akt Axis.
2025Journal of medicinal chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota causally affects ulcerative colitis by potential mediation of plasma metabolites: A Mendelian randomization study.
2025Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Component characterization of Zanthoxylum nitidum extract and its anti-colitis effect through regulating PPARγ/NF-κB/iNOS signaling pathway and gut microbiota.
2025International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Thymoquinone mediated hedgehog pathway activation and gut microbiota modulation in mouse colitis.
2025Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Phage therapy modulates the gut microbiome and immune responses in non-typhoidal Salmonella-induced colitis.
2025Food research international (Ottawa, Ont.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus johnsonii-derived extracellular vesicles restore mucosal immunity via taurine-linked Th17/Treg and IgA/IgG regulation in colitis.
2025Journal of nanobiotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Degree of Mucosa-Associated Microecological Imbalance in Ulcerative Colitis Patients with Different Mayo Score and Its Relationship with Mucosal Mechanical Barrier Damage.
2025The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
18 papersColitis in transgenic and knockout animals as models of human inflammatory bowel disease.
1999Immunological reviews
Relevant review or meta-analysis for the signal-disease area.
Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis.
2006Nature clinical practice. Gastroenterology & hepatology
Relevant review or meta-analysis for the signal-disease area.
Medical management of left-sided ulcerative colitis and ulcerative proctitis: critical evaluation of therapeutic trials.
2006Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
Escherichia coli Nissle 1917 in Ulcerative Colitis Treatment: Systematic Review and Meta-analysis.
2015Journal of gastrointestinal and liver diseases : JGLD
Relevant review or meta-analysis for the signal-disease area.
Probiotics and prebiotics in ulcerative colitis.
2016Best practice & research. Clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Role and mechanisms of action of Escherichia coli Nissle 1917 in the maintenance of remission in ulcerative colitis patients: An update.
2016World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Adherent-invasive Escherichia coli in inflammatory bowel disease.
2018Gut
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Is a Potential Biomarker in Inflammatory Bowel Disease.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
The double-edged sword of probiotic supplementation on gut microbiota structure in Helicobacter pylori management.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Review article: The complex interplay between diet and Escherichia coli in inflammatory bowel disease.
2023Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis.
2025Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Relevant review or meta-analysis for the signal-disease area.
Impact of Psychopathology and Gut Microbiota on Disease Progression in Ulcerative Colitis: A Five-Year Follow-Up Study.
2025Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Is the microbiome the answer to inflammatory bowel disease: systematic review.
2025Langenbeck's archives of surgery
Relevant review or meta-analysis for the signal-disease area.
The Molecular Landscape of Inflammation in Inflammatory Bowel Disease (IBD): Targets for Precision Medicine.
2025Biomedicines
Relevant review or meta-analysis for the signal-disease area.
Ulcerative colitis. Epidemiology and aetiology, course and prognosis.
1971British medical journal
Relevant review or meta-analysis for the signal-disease area.
The colitides.
1982Radiologic clinics of North America
Relevant review or meta-analysis for the signal-disease area.
Escherichia coli and ulcerative colitis.
1997Journal of the Royal Society of Medicine
Relevant review or meta-analysis for the signal-disease area.