preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Proteobacteria
atopic dermatitis
Proteobacteria has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Proteobacteria shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
proteobacteria
Credibility score
55
Human translation
2/5
Reproducibility
4/5
Novelty
3/5
Actionability
3/5
Credibility 55Human translation 2/5Reproducibility 4/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
13 papersModulation of fecal polyamines by viewing humorous films in patients with atopic dermatitis.
2010European journal of gastroenterology & hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Nonpathogenic bacteria alleviating atopic dermatitis inflammation induce IL-10-producing dendritic cells and regulatory Tr1 cells.
2014The Journal of investigative dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota.
2014Allergology international : official journal of the Japanese Society of Allergology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiome and Food Allergy in Pediatric Atopic Dermatitis: A Cross-Sectional Pilot Study.
2018International archives of allergy and immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the skin microbiome are associated with disease severity and treatment in the perioral zone of the skin of infants with atopic dermatitis.
2019European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Development of the Microbiota and Associations With Birth Mode, Diet, and Atopic Disorders in a Longitudinal Analysis of Stool Samples, Collected From Infancy Through Early Childhood.
2020Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diagnostic Models for Atopic Dermatitis Based on Serum Microbial Extracellular Vesicle Metagenomic Analysis: A Pilot Study.
2020Allergy, asthma & immunology research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota development during infancy: Impact of introducing allergenic foods.
2021The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Gut Microbiota Between Infants with Atopic Dermatitis and Healthy Controls in Guangzhou, China.
2021Journal of asthma and allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An insight into the gut microbiota of healthy and allergic West Highland Whiter Terrier dogs.
2025PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication.
2025Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Isolation of cDNA clones coding for IgE autoantigens with serum IgE from atopic dermatitis patients.
1998FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersImmunoglobulin E antibody reactivity to bacterial antigens in atopic dermatitis patients.
2011Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Human primary paper with plausible association relevance to the disease context.
Initial Evidence of Distinguishable Bacterial and Fungal Dysbiosis in the Skin of Patients with Atopic Dermatitis or Netherton Syndrome.
2021The Journal of investigative dermatology
Human primary paper with plausible association relevance to the disease context.
Timeliness of DTaP-IPV-Hib Vaccination and Development of Atopic Dermatitis Between 4 Months and 1 Year of Age-Register-Based Cohort Study.
2021The journal of allergy and clinical immunology. In practice
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
25 papersThe role of Helicobacter pylori in urticaria and atopic dermatitis.
2006Skinmed
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study.
2007Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption.
2009The Journal of investigative dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shifts in human skin and nares microbiota of healthy children and adults.
2012Genome medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiome of affected and unaffected skin of patients with atopic dermatitis before and after emollient treatment.
2014Journal of drugs in dermatology : JDD
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Skin microbiota and atopic dermatitis: toward new therapeutic options?].
2015Annales de dermatologie et de venereologie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Skin microbiota of first cousins affected by psoriasis and atopic dermatitis.
2016Clinical and molecular allergy : CMA
Disease-relevant preclinical or model-based paper useful as supporting evidence.
House dust mites as potential carriers for IgE sensitization to bacterial antigens.
2018Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Not Available].
2017Annales de dermatologie et de venereologie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
First-in-human topical microbiome transplantation with Roseomonas mucosa for atopic dermatitis.
2018JCI insight
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Differing Virulence of Healthy Skin Commensals in Mouse Models of Infection.
2018Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical ozone therapy restores microbiome diversity in atopic dermatitis.
2020International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dysbiotic Lesional Microbiome With Filaggrin Missense Variants Associate With Atopic Dermatitis in India.
2020Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dialogue between gastrointestinal tract and skin: New insights into the Helicobacter pylori and atopic dermatitis.
2021Helicobacter
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Description and comparison of the skin and ear canal microbiota of non-allergic and allergic German shepherd dogs using next generation sequencing.
2021PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Pilot Study: Composition and Diversity of 16S rRNA Based Skin Bacterial Microbiome in Indonesian Atopic Dermatitis Population.
2021Clinical, cosmetic and investigational dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Diaper area skin microflora of normal children and children with atopic dermatitis.
1987Journal of clinical microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alterations of Epidermal Lipid Profiles and Skin Microbiome in Children With Atopic Dermatitis.
2023Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs.
2023Veterinary sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Citrobacter koseri inhibits the growth of Staphylococcus epidermidis by suppressing iron utilization.
2024Biochemical and biophysical research communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Attenuation of allergen-specific immunotherapy for atopic dermatitis by ectopic colonization of Brevundimonas vesicularis in the intestine.
2023Cell reports. Medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis.
2024Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Disseminated bartonellosis and EBV reactivation in an adolescent treated with upadacitinib.
2025The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Efficacy and safety of indigo naturalis oil extract (Lindioil ointment) for the treatment of atopic dermatitis: a randomized, crossover, evaluator-blinded, controlled trial.
2025Frontiers in pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pediatric autoimmune gastritis: An international, multicentric study.
2025Journal of pediatric gastroenterology and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
9 papersHelicobacter pylori infection and dermatologic diseases.
2009European journal of dermatology : EJD
Relevant review or meta-analysis for the signal-disease area.
Defensin-barbed innate immunity: clinical associations in the pediatric population.
2010Pediatrics
Relevant review or meta-analysis for the signal-disease area.
Dual-coated lactic acid bacteria: an emerging innovative technology in the field of probiotics.
2016Future microbiology
Relevant review or meta-analysis for the signal-disease area.
Helicobacter pylori and skin disorders: a comprehensive review of the available literature.
2020European review for medical and pharmacological sciences
Relevant review or meta-analysis for the signal-disease area.
The role of gut microbiome in inflammatory skin disorders: A systematic review.
2022Dermatology reports
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in various childhood disorders: Implication and indications.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Understanding immunological origins of atopic dermatitis through multi-omic analysis.
2022Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Relevant review or meta-analysis for the signal-disease area.
The power and potential of mitochondria transfer.
2023Nature
Relevant review or meta-analysis for the signal-disease area.
Beyond the Skin: Exploring the Gut-Skin Axis in Chronic Spontaneous Urticaria and Other Inflammatory Skin Diseases.
2025Biomedicines
Relevant review or meta-analysis for the signal-disease area.