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Prevotella copri

obesity

Prevotella copri appears to be a strong and relatively human-grounded signal in obesity.

Prevotella copri shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.

prevotella_copri
Credibility score
100
Human translation
4/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 100Human translation 4/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • meaningful supporting human literature
  • dense review literature
Main caveats
  • directionality and confounding still require curated review

Internal review flags

1 flags
review_heavy

Review literature is very dense relative to primary central evidence.

Primary central evidence

37 papers
Detection of Increased Plasma Interleukin-6 Levels and Prevalence of Prevotella copri and Bacteroides vulgatus in the Feces of Type 2 Diabetes Patients.
2017
Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Improvement in cardiometabolic risk markers following a multifunctional diet is associated with gut microbial taxa in healthy overweight and obese subjects.
2018
European journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Decreased microbial co-occurrence network stability and SCFA receptor level correlates with obesity in African-origin women.
2018
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Multi-omics Approach to Unraveling the Microbiome-Mediated Effects of Arabinoxylan Oligosaccharides in Overweight Humans.
2019
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease.
2019
Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota modulation with long-chain corn bran arabinoxylan in adults with overweight and obesity is linked to an individualized temporal increase in fecal propionate.
2020
Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity.
2020
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.
2021
Nature medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Korean-Style Balanced Diet Has a Potential Connection with Ruminococcaceae Enterotype and Reduction of Metabolic Syndrome Incidence in Korean Adults.
2021
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of gut microbiota between adults with autism spectrum disorder and obese adults.
2021
PeerJ
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.
2021
Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbial compositional and functional changes associated with impaired inhibitory control in patients with cirrhosis.
2021
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic analysis revealed the potential role of gut microbiome in gout.
2021
NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota in people with obesity.
2021
PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial.
2022
Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotypes in asthenospermia patients with obesity.
2022
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Machine learning framework for gut microbiome biomarkers discovery and modulation analysis in large-scale obese population.
2022
BMC genomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Signature of Obese Adults Across Different Classifications.
2022
Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A metagenomic study identifies a Prevotella copri enriched microbial profile associated with non-alcoholic steatohepatitis in subjects with obesity.
2023
Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut-microbiota in children and adolescents with obesity: inferred functional analysis and machine-learning algorithms to classify microorganisms.
2023
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of synbiotic supplementation on intestinal microbiota composition in children and adolescents with exogenous obesity: (Probesity-2 trial).
2023
Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Physical Activity and Nutrition Education on the Gut Microbiota in Overweight and Obese Children.
2023
Children (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Compliance with Nutritional Recommendations and Gut Microbiota Profile in Galician Overweight/Obese and Normal-Weight Individuals.
2023
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Glucose-lowering effects of a synbiotic combination containing Pediococcus acidilactici in C. elegans and mice.
2023
Diabetologia
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Liver Bacterial Colonization in Patients with Obesity and Gut Dysbiosis.
2024
Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024
Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Recipient microbiome-related features predicting metabolic improvement following fecal microbiota transplantation in adults with severe obesity and metabolic syndrome: a secondary analysis of a phase 2 clinical trial.
2024
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Adolescent gut microbiome imbalance and its association with immune response in inflammatory bowel diseases and obesity.
2024
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbial Changes Associated With Obesity in Youth With Type 1 Diabetes.
2025
The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy.
2024
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota: Association with Fiber Intake, Ultra-Processed Food Consumption, Sex, Body Mass Index, and Socioeconomic Status in Medical Students.
2024
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiotic Microbiome-Metabolome Axis in Childhood Obesity and Metabolic Syndrome.
2025
Journal of dental research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-term arsenic exposure perturbs gut microbial diversity, composition and predicts metabolic dysregulation.
2025
Journal of hazardous materials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides- and Prevotella-enriched gut microbial clusters associate with metabolic risks.
2025
Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiota composition and cardiometabolic parameters in healthy adults.
2025
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial dysbiosis in oral cavity determines obesity status in adolescents.
2025
Cellular and molecular life sciences : CMLS
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prevotella copri promotes white adipose browning and ameliorates adiposity.
2025
Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

3 papers
Schizophrenia Patients With Prevotella-Enterotype Have a Higher Risk of Obesity.
2022
Frontiers in psychiatry
Human primary paper with plausible association relevance to the disease context.
Gut microbial changes associated with obesity in youth with type 1 diabetes.
2023
medRxiv : the preprint server for health sciences
Relevant preprint retained as supporting evidence, not central evidence.
The association between gut microbiota and metabolic dysfunction-associated steatotic liver disease (MASLD): a case-control study.
2025
BMC pediatrics
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

15 papers
Gut Microbiota and Host Metabolism: What Relationship.
2018
Neuroendocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.
2020
The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dominant gut Prevotella copri in gastrectomised non-obese diabetic Goto-Kakizaki rats improves glucose homeostasis through enhanced FXR signalling.
2020
Diabetologia
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Evaluation of hypoglycemic effect, safety and immunomodulation of Prevotella copri in mice.
2021
Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Airway microbiota and immune mediator relationships differ in obesity and asthma.
2023
The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The effects of fresh mango consumption on gut health and microbiome - Randomized controlled trial.
2023
Food science & nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Prevotella copri on insulin, gut microbiota and bile acids.
2024
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.
2024
Biological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sourdough bread enriched with exopolysaccharides and gazpacho by-products modulates in vitro the microbiota dysbiosis.
2024
International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Obesity as Inducer of Cognitive Function Decline via Dysbiosis of Gut Microbiota in Rats.
2024
Brain sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut-derived IL-13 contributes to growth via promoting hepatic IGF-1 production.
2024
Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Association Between Prevotella copri and Advanced Fibrosis in the Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease.
2025
Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Associations Between Oral Microbiota Pathogens and Elevated Depressive and Anxiety Symptoms in Men.
2025
Depression and anxiety
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anthocyanins from blueberry and blackberry ameliorate metabolic syndrome by Prevotella histicola and acetic acid.
2025
NPJ science of food
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial-derived 3-phenylpropionic acid orchestrates immune-progenitor cell crosstalk to promote beige adipogenesis and energy expenditure.
2026
Cell metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

20 papers
The gut microbiome.
2014
Inflammation & allergy drug targets
Relevant review or meta-analysis for the signal-disease area.
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
2018
European journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Diet and microbiota linked in health and disease.
2018
Food & function
Relevant review or meta-analysis for the signal-disease area.
The gut microbiome and elevated cardiovascular risk in obesity and autoimmunity.
2018
Atherosclerosis
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018
Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Human gut microbiome: hopes, threats and promises.
2018
Gut
Relevant review or meta-analysis for the signal-disease area.
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review.
2018
Childhood obesity (Print)
Relevant review or meta-analysis for the signal-disease area.
Microbial enterotypes in personalized nutrition and obesity management.
2018
The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota phenotypes of obesity.
2019
NPJ biofilms and microbiomes
Relevant review or meta-analysis for the signal-disease area.
Next generation probiotics in disease amelioration.
2019
Journal of food and drug analysis
Relevant review or meta-analysis for the signal-disease area.
Modulation of the human gut microbiota by phenolics and phenolic fiber-rich foods.
2020
Comprehensive reviews in food science and food safety
Relevant review or meta-analysis for the signal-disease area.
Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.
2021
Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.
2021
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022
Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
Personal diet-microbiota interactions and weight loss.
2022
The Proceedings of the Nutrition Society
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiome and Female Health.
2022
Biology
Relevant review or meta-analysis for the signal-disease area.
Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders.
2023
Leukemia
Relevant review or meta-analysis for the signal-disease area.
Dried Fruits: Bioactives, Effects on Gut Microbiota, and Possible Health Benefits-An Update.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Male Tract Microbiota and Male Infertility.
2024
Cells
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.
2025
Gut microbes
Relevant review or meta-analysis for the signal-disease area.