sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
fulltoplow inflation risk
Prevotella copri
inflammatory bowel disease
Prevotella copri looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Prevotella copri shows a strong literature footprint in inflammatory bowel disease, with substantial central evidence and broader supporting literature.
prevotella_copri
Credibility score
67
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
5/5
Credibility 67Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
21 papersMucosal and invading bacteria in patients with inflammatory bowel disease compared with controls.
2002Scandinavian journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis of salivary microbiota in inflammatory bowel disease and its association with oral immunological biomarkers.
2014DNA research : an international journal for rapid publication of reports on genes and genomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis.
2017World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis.
2017Genome biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut mucosal-associated microbiota better discloses inflammatory bowel disease differential patterns than faecal microbiota.
2019Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered fecal bacterial composition correlates with disease activity in inflammatory bowel disease and the extent of IL8 induction.
2019Current research in translational medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota profiles in treatment-naïve pediatric inflammatory bowel disease - associations with disease phenotype, treatment, and outcome.
2019Clinical and experimental gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease.
2020Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Longitudinal Changes in Fecal Calprotectin Levels Among Pregnant Women With and Without Inflammatory Bowel Disease and Their Babies.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men.
2021Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations and Prediction of Functional Profiles of Gut Microbiota After Fecal Microbiota Transplantation for Iranian Recurrent Clostridioides difficile Infection with Underlying Inflammatory Bowel Disease: A Pilot Study.
2022Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of gut microbiome profiles in common marmosets (Callithrix jacchus) in health and intestinal disease.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota in congenital chloride diarrhea and inflammatory bowel disease.
2022PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Phylogenetic analysis of Prevotella copri from fecal and mucosal microbiota of IBS and IBD patients.
2023Therapeutic advances in gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Insight into gut dysbiosis of patients with inflammatory bowel disease and ischemic colitis.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Microbiome in Quiescent Crohn's Disease With Persistent Symptoms Show Disruptions in Microbial Sulfur and Tryptophan Pathways.
2024Gastro hep advances
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Bacterial Composition and Nutritional Implications in Mexican and Spanish Individuals with Inflammatory Bowel Disease Compared to Healthy Controls.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparative analysis of dominant gut microbiota in Inflammatory Bowel Disease patients and healthy individuals: A case-control study.
2025New microbes and new infections
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dialister-driven succinate accumulation is associated with disease activity and postoperative recurrence in Crohn's disease.
2025World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
16 papersSubgingival microflora in inflammatory bowel disease patients with untreated periodontitis.
2013European journal of gastroenterology & hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prebiotics effects in vitro of polysaccharides from tea flowers on gut microbiota of healthy persons and patients with inflammatory bowel disease.
2020International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Critical Role of Intestinal Microbiota in ATF3-Mediated Gut Immune Homeostasis.
2020Journal of immunology (Baltimore, Md. : 1950)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-throughput sequencing provides insights into oral microbiota dysbiosis in association with inflammatory bowel disease.
2021Genomics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
ZFP90 drives the initiation of colitis-associated colorectal cancer via a microbiota-dependent strategy.
2021Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Western and non-western gut microbiomes reveal new roles of Prevotella in carbohydrate metabolism and mouth-gut axis.
2021NPJ biofilms and microbiomes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
2022Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome signatures of Yorkshire Terrier enteropathy during disease and remission.
2023Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
CXCL10 as a shared specific marker in rheumatoid arthritis and inflammatory bowel disease and a clue involved in the mechanism of intestinal flora in rheumatoid arthritis.
2023Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Isolation, identification, and significance of salivary Veillonella spp., Prevotella spp., and Prevotella salivae in patients with inflammatory bowel disease.
2023Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
pH-responsive CuS/DSF/EL/PVP nanoplatform alleviates inflammatory bowel disease in mice via regulating gut immunity and microbiota.
2024Acta biomaterialia
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mendelian randomization and genetic pleiotropy analysis for the connection between inflammatory bowel disease and Alzheimer's disease.
2025Progress in neuro-psychopharmacology & biological psychiatry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
11 papersDoes our food (environment) change our gut microbiome ('in-vironment'): a potential role for inflammatory bowel disease?
2012Digestive diseases (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Oral-Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?
2019Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
The Microbiome in Hidradenitis Suppurativa: A Review.
2021Dermatology and therapy
Relevant review or meta-analysis for the signal-disease area.
Modulation of the human gut microbiota by phenolics and phenolic fiber-rich foods.
2020Comprehensive reviews in food science and food safety
Relevant review or meta-analysis for the signal-disease area.
Repeated Fecal Microbial Transplantations and Antibiotic Pre-Treatment Are Linked to Improved Clinical Response and Remission in Inflammatory Bowel Disease: A Systematic Review and Pooled Proportion Meta-Analysis.
2021Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Gut bacteriome in inflammatory bowel disease: An update on recent advances.
2024Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Understanding the role of ursodeoxycholic acid and gut microbiome in non-alcoholic fatty liver disease: current evidence and perspectives.
2024Frontiers in pharmacology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis.
2025Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Relevant review or meta-analysis for the signal-disease area.
Hidradenitis Suppurativa from a Multi-Omic Scope.
2025Journal of cutaneous medicine and surgery
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.