Differences in fecal microbial metabolites and microbiota of children with autism spectrum disorders.
2018Anaerobe
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Prevotella copri
autism
Prevotella copri looks like a credible signal in autism, though some caution is still warranted.
Prevotella copri shows a strong literature footprint in autism, with substantial central evidence and broader supporting literature.
prevotella_copri
Credibility score
65
Human translation
5/5
Reproducibility
4/5
Novelty
2/5
Actionability
4/5
Credibility 65Human translation 5/5Reproducibility 4/5Novelty 2/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- dense review literature
Main caveats
- directionality and confounding still require curated review
Primary central evidence
20 papersInsular resting state functional connectivity is associated with gut microbiota diversity.
2019The European journal of neuroscience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-term benefit of Microbiota Transfer Therapy on autism symptoms and gut microbiota.
2019Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered gut microbial profile is associated with abnormal metabolism activity of Autism Spectrum Disorder.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the Gut Microbiota of Children with Autism Spectrum Disorder.
2020Autism research : official journal of the International Society for Autism Research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Potential of gut microbiome for detection of autism spectrum disorder.
2020Microbial pathogenesis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of gut microbiota between adults with autism spectrum disorder and obese adults.
2021PeerJ
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Computational Framework for Studying Gut-Brain Axis in Autism Spectrum Disorder.
2022Frontiers in physiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Ecology and Inferred Functions in Children With ASD Compared to Neurotypical Subjects.
2022Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Benefits of Gut Microbiota Reconstitution by Beta 1,3-1,6 Glucans in Subjects with Autism Spectrum Disorder and Other Neurodegenerative Diseases.
2023Journal of Alzheimer's disease : JAD
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota and Short-chain Fatty Acids in Chinese Children with Constipated Autism Spectrum Disorder.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alteration of the gut microbiota profile in children with autism spectrum disorder in China.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Precision synbiotics increase gut microbiome diversity and improve gastrointestinal symptoms in a pilot open-label study for autism spectrum disorder.
2024mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comprehensive Analysis of Gut Microbiota Composition and Functional Metabolism in Children with Autism Spectrum Disorder and Neurotypical Children: Implications for Sex-Based Differences and Metabolic Dysregulation.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of Gut Bacterial and Fungal Microbiota in Children with Autism Spectrum Disorder and Their Non-Autistic Siblings.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota of children with autism spectrum disorder and healthy siblings: A comparative study.
2024Experimental and therapeutic medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Omic characterizing and targeting gut dysbiosis in children with autism spectrum disorder: symptom alleviation through combined probiotic and medium-carbohydrate diet intervention - a pilot study.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Resilience of human gut microbiomes in autism spectrum disorder: measured using stiffness network analysis.
2025Microbiology spectrum
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Age-Dependent Gut Microbiome Dysbiosis in Autism Spectrum Disorder and the Role of Key Bacterial Ratios.
2025Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota characteristics and therapeutic effects of fecal microbiota transplantation in children with autism spectrum disorder in central China: a combined cross-sectional and prospective study.
2025Frontiers in pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersBacterial variation in the oral microbiota in multiple sclerosis patients.
2021PloS one
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
6 papersMicrobiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study.
2017Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Study of the gut Microbiome Profile in Children with Autism Spectrum Disorder: a Single Tertiary Hospital Experience.
2020Journal of molecular neuroscience : MN
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Therapeutic Effects of the In Vitro Cultured Human Gut Microbiota as Transplants on Altering Gut Microbiota and Improving Symptoms Associated with Autism Spectrum Disorder.
2020Microbial ecology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shotgun Metagenomics Study Suggests Alteration in Sulfur Metabolism and Oxidative Stress in Children with Autism and Improvement after Microbiota Transfer Therapy.
2022International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multi-level analysis of the gut-brain axis shows autism spectrum disorder-associated molecular and microbial profiles.
2023Nature neuroscience
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fresh Washed Microbiota Transplantation Alters Gut Microbiota Metabolites to Ameliorate Sleeping Disorder Symptom of Autistic Children.
2023Journal of microbiology (Seoul, Korea)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
13 papersAltered composition and function of intestinal microbiota in autism spectrum disorders: a systematic review.
2019Translational psychiatry
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD.
2019Medicina (Kaunas, Lithuania)
Relevant review or meta-analysis for the signal-disease area.
An approach to gut microbiota profile in children with autism spectrum disorder.
2020Environmental microbiology reports
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota changes in children with autism spectrum disorder: a systematic review.
2020Gut pathogens
Relevant review or meta-analysis for the signal-disease area.
The Link Between Autism Spectrum Disorder And Gastrointestinal Microbiota.
2021Journal of Ayub Medical College, Abbottabad : JAMC
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Neuropsychiatric Diseases - Creation of An Atlas-Based on Quantified Evidence.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.
2022Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
The Role of Gut Microbiota in Various Neurological and Psychiatric Disorders-An Evidence Mapping Based on Quantified Evidence.
2023Mediators of inflammation
Relevant review or meta-analysis for the signal-disease area.
Genus-Level Analysis of Gut Microbiota in Children with Autism Spectrum Disorder: A Mini Review.
2023Children (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Liposomal Epigallocatechin-3-Gallate for the Treatment of Intestinal Dysbiosis in Children with Autism Spectrum Disorder: A Comprehensive Review.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
Intervention and research progress of gut microbiota-immune-nervous system in autism spectrum disorders among students.
2025Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
The endocannabinoidome-gut microbiome-brain axis as a novel therapeutic target for autism spectrum disorder.
2025Journal of biomedical science
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota and Autism: Unlocking Connections.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.