preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Prevotella
ulcerative colitis
Prevotella has meaningful literature visibility in ulcerative colitis, but the current evidence mix suggests a substantial risk of overclaiming.
Prevotella shows a strong literature footprint in ulcerative colitis, with substantial central evidence and broader supporting literature.
prevotella
Credibility score
62
Human translation
2/5
Reproducibility
4/5
Novelty
3/5
Actionability
3/5
Credibility 62Human translation 2/5Reproducibility 4/5Novelty 3/5Actionability 3/5
Why this scores the way it does
- strong central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
19 papersPrevalence of Bacteroides and Prevotella spp. in ulcerative colitis.
2006Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations in the mucosa-associated bacterial composition in Crohn's disease: a pilot study.
2016International journal of colorectal disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Distinct gut microbiota profiles in patients with primary sclerosing cholangitis and ulcerative colitis.
2017World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Longitudinal Analyses of Gut-Associated Bacterial Microbiota in Ulcerative Colitis Patients.
2018Archives of Iranian medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
IL-13 mRNA Tissue Content Identifies Two Subsets of Adult Ulcerative Colitis Patients With Different Clinical and Mucosa-Associated Microbiota Profiles.
2020Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota and Related Metabolites Were Disturbed in Ulcerative Colitis and Partly Restored After Mesalamine Treatment.
2020Frontiers in pharmacology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Study of microbiome changes in patients with ulcerative colitis in the Central European part of Russia.
2021Heliyon
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intestinal flora differences between patients with ulcerative colitis of different ethnic groups in China.
2021Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-Term Efficacy of Low-Intensity Single Donor Fecal Microbiota Transplantation in Ulcerative Colitis and Outcome-Specific Gut Bacteria.
2021Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial changes in stool, saliva, serum, and urine before and after anti-TNF-α therapy in patients with inflammatory bowel diseases.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Associated with Clinical Relapse in Patients with Quiescent Ulcerative Colitis.
2022Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparison of Metabolites and Gut Microbes between Patients with Ulcerative Colitis and Healthy Individuals for an Integrative Medicine Approach to Ulcerative Colitis-A Pilot Observational Clinical Study (STROBE Compliant).
2022Diagnostics (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Insight into gut dysbiosis of patients with inflammatory bowel disease and ischemic colitis.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Impacts of Fecal Microbiota Transplantation from Same Sex on the Symptoms of Ulcerative Colitis Patients.
2023Polish journal of microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exclusive Enteral Nutrition Mediates Beneficial Gut Microbiome Enrichment in Acute Severe Colitis.
2024Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis.
2024Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Long-term arsenic exposure perturbs gut microbial diversity, composition and predicts metabolic dysregulation.
2025Journal of hazardous materials
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fungal-Bacterial Dysbiosis in IBD: Microbial Biomarkers of Disease Activity.
2025MicrobiologyOpen
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
25 papersComparison of the microbial community structure between inflamed and non-inflamed sites in patients with ulcerative colitis.
2018Journal of gastroenterology and hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Chitosan Ameliorates DSS-Induced Ulcerative Colitis Mice by Enhancing Intestinal Barrier Function and Improving Microflora.
2019International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis.
2021Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of ShenLing BaiZhu San Supplementation on Gut Microbiota and Oxidative Stress in Rats with Ulcerative Colitis.
2021Evidence-based complementary and alternative medicine : eCAM
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
2022Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics.
2021Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome alterations in colitis rats after moxibustion at bilateral Tianshu acupoints.
2022BMC gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Eurotium cristatum, a Probiotic Fungus from Fuzhuan Brick Tea, and Its Polysaccharides Ameliorated DSS-Induced Ulcerative Colitis in Mice by Modulating the Gut Microbiota.
2022Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mesona chinensis Benth Polysaccharides Alleviate DSS-Induced Ulcerative Colitis via Inhibiting of TLR4/MAPK/NF-κB Signaling Pathways and Modulating Intestinal Microbiota.
2022Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Study of the gut microbiome in Egyptian patients with active ulcerative colitis.
2023Revista de gastroenterologia de Mexico (English)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Functional analysis of metalloenzymes from human gut microbiota and their role in ulcerative colitis.
2023Journal of applied microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A special polysaccharide hydrogel coated on Brasenia schreberi: preventive effects against ulcerative colitis via modulation of gut microbiota.
2023Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Panax quinquefolius polysaccharides ameliorate ulcerative colitis in mice induced by dextran sulfate sodium.
2023Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tamarind Seed Polysaccharide Hydrolysate Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis via Regulating the Gut Microbiota.
2023Pharmaceuticals (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sea Cucumber Peptides Ameliorate DSS-Induced Ulcerative Colitis: The Role of the Gut Microbiota, the Intestinal Barrier, and Macrophage Polarization.
2023Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pulsatillae radix extract alleviates DSS-induced colitis via modulating gut microbiota and inflammatory signaling pathway in mice.
2023Heliyon
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Turtle peptide and its derivative peptide ameliorated DSS-induced ulcerative colitis by inhibiting inflammation and modulating the composition of the gut microbiota.
2024International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus plantarum-Derived Extracellular Vesicles Modulate Macrophage Polarization and Gut Homeostasis for Alleviating Ulcerative Colitis.
2024Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oyster Peptides Ameliorate Dextran Sulfate Sodium-Induced Ulcerative Colitis via Modulating the Gut Microbiota and Inhibiting the TLR4/NF-κB Pathway.
2024Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
β-Glucan Extracted from Pichia kudriavzevii DPUL-51-6Y, Kluyveromyces marxianus DPUL-F15, and Saccharomyces cerevisiae DPUL-C6 Shows Ameliorating Effects on DSS-Induced Ulcerative Colitis on BALB/c Mice.
2025Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Proton pump inhibitors and gut microbiota dysbiosis: insights into the pathogenesis of ulcerative colitis.
2025Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pectic polysaccharides from Mongolian medicinal Hypecoum leptocarpum: Structure and ulcerative colitis amelioration via gut microbiota and intestinal inflammation regulation.
2026Carbohydrate polymers
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
5 papersPrevotella: An insight into its characteristics and associated virulence factors.
2022Microbial pathogenesis
Relevant review or meta-analysis for the signal-disease area.
Microbiome in Hidradenitis Suppurativa-What We Know and Where We Are Heading.
2022International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota-based discriminative model for patients with ulcerative colitis: A meta-analysis and real-world study.
2024Medicine
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Features in Relation to Fecal Microbiota Transplantation Outcome in Ulcerative Colitis: A Systematic Review and Meta-Analysis.
2025Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Relevant review or meta-analysis for the signal-disease area.
Salivary Biomarkers in Crohn's Disease and Ulcerative Colitis: A Scoping Review and Evidence Map.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.