review_heavy
Review literature is very dense relative to primary central evidence.
fulltoplow inflation risk
Prevotella
obesity
Prevotella appears to be a strong and relatively human-grounded signal in obesity.
Prevotella shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
prevotella
Credibility score
82
Human translation
5/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 82Human translation 5/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
23 papersA High Protein Calorie Restriction Diet Alters the Gut Microbiome in Obesity.
2020Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome connections with host metabolism and habitual diet from 1,098 deeply phenotyped individuals.
2021Nature medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metagenomic analysis revealed the potential role of gut microbiome in gout.
2021NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characteristics of gut microbiota in people with obesity.
2021PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The effects of the Green-Mediterranean diet on cardiometabolic health are linked to gut microbiome modifications: a randomized controlled trial.
2022Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Enterotypes in asthenospermia patients with obesity.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Signature of Obese Adults Across Different Classifications.
2022Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery.
2023PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut-microbiota in children and adolescents with obesity: inferred functional analysis and machine-learning algorithms to classify microorganisms.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Glucose-lowering effects of a synbiotic combination containing Pediococcus acidilactici in C. elegans and mice.
2023Diabetologia
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Liver Bacterial Colonization in Patients with Obesity and Gut Dysbiosis.
2024Obesity surgery
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.
2024Environment international
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Recipient microbiome-related features predicting metabolic improvement following fecal microbiota transplantation in adults with severe obesity and metabolic syndrome: a secondary analysis of a phase 2 clinical trial.
2024Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between childhood obesity and gut microbiota: 16S rRNA gene sequencing-based cohort study.
2024World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impact of Gut Microbiota and SCFAs in the Pathogenesis of PCOS and the Effect of Metformin Therapy.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota: Association with Fiber Intake, Ultra-Processed Food Consumption, Sex, Body Mass Index, and Socioeconomic Status in Medical Students.
2024Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiotic Microbiome-Metabolome Axis in Childhood Obesity and Metabolic Syndrome.
2025Journal of dental research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacteroides- and Prevotella-enriched gut microbial clusters associate with metabolic risks.
2025Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The Effect of Probiotics on the Improvement of Body Weight and Fat.
2025Food science & nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The association between gut microbiota composition and cardiometabolic parameters in healthy adults.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial dysbiosis in oral cavity determines obesity status in adolescents.
2025Cellular and molecular life sciences : CMLS
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral and fecal microbiota in Chinese adults with obesity reveal potential niche-specific microbiota associated with obesity.
2025BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Prevotella copri promotes white adipose browning and ameliorates adiposity.
2025Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersSchizophrenia Patients With Prevotella-Enterotype Have a Higher Risk of Obesity.
2022Frontiers in psychiatry
Human primary paper with plausible association relevance to the disease context.
Oral microbiome changes in subjects with obesity following bariatric surgery compared to lean counterparts.
2025Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.
The association between gut microbiota and metabolic dysfunction-associated steatotic liver disease (MASLD): a case-control study.
2025BMC pediatrics
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
7 papersMicrobial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.
2020The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Subgingival microbiota in overweight and obese young adults with no destructive periodontal disease.
2021Journal of periodontology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Airway microbiota and immune mediator relationships differ in obesity and asthma.
2023The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Prevotella copri on insulin, gut microbiota and bile acids.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-fat diet, microbiome-gut-brain axis signaling, and anxiety-like behavior in male rats.
2024Biological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Associations Between Oral Microbiota Pathogens and Elevated Depressive and Anxiety Symptoms in Men.
2025Depression and anxiety
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Anthocyanins from blueberry and blackberry ameliorate metabolic syndrome by Prevotella histicola and acetic acid.
2025NPJ science of food
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
20 papersThe gut microbiome.
2014Inflammation & allergy drug targets
Relevant review or meta-analysis for the signal-disease area.
Influence of gut microbiota on the development and progression of nonalcoholic steatohepatitis.
2018European journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Diet and microbiota linked in health and disease.
2018Food & function
Relevant review or meta-analysis for the signal-disease area.
The gut microbiome and elevated cardiovascular risk in obesity and autoimmunity.
2018Atherosclerosis
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Human gut microbiome: hopes, threats and promises.
2018Gut
Relevant review or meta-analysis for the signal-disease area.
Childhood Obesity and Firmicutes/Bacteroidetes Ratio in the Gut Microbiota: A Systematic Review.
2018Childhood obesity (Print)
Relevant review or meta-analysis for the signal-disease area.
Microbial enterotypes in personalized nutrition and obesity management.
2018The American journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota phenotypes of obesity.
2019NPJ biofilms and microbiomes
Relevant review or meta-analysis for the signal-disease area.
Modulation of the human gut microbiota by phenolics and phenolic fiber-rich foods.
2020Comprehensive reviews in food science and food safety
Relevant review or meta-analysis for the signal-disease area.
Diet, adiposity, and the gut microbiota from infancy to adolescence: A systematic review.
2021Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiome Composition in Obese and Non-Obese Persons: A Systematic Review and Meta-Analysis.
2021Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
Personal diet-microbiota interactions and weight loss.
2022The Proceedings of the Nutrition Society
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiome and Female Health.
2022Biology
Relevant review or meta-analysis for the signal-disease area.
Dietary and microbiome evidence in multiple myeloma and other plasma cell disorders.
2023Leukemia
Relevant review or meta-analysis for the signal-disease area.
Dried Fruits: Bioactives, Effects on Gut Microbiota, and Possible Health Benefits-An Update.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
Male Tract Microbiota and Male Infertility.
2024Cells
Relevant review or meta-analysis for the signal-disease area.
Cannabis and cannabinoid-microbiome interactions in varied clinical contexts: A comprehensive systematic review.
2025Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis of shotgun sequencing of gut microbiota in obese children with MASLD or MASH.
2025Gut microbes
Relevant review or meta-analysis for the signal-disease area.