Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota.
2012Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
fulltoplow inflation risk
Prevotella
crohn's disease
Prevotella looks like a credible signal in crohn's disease, though some caution is still warranted.
Prevotella shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
prevotella
Credibility score
68
Human translation
3/5
Reproducibility
4/5
Novelty
2/5
Actionability
4/5
Credibility 68Human translation 3/5Reproducibility 4/5Novelty 2/5Actionability 4/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- directionality and confounding still require curated review
Primary central evidence
19 papersAlterations in the mucosa-associated bacterial composition in Crohn's disease: a pilot study.
2016International journal of colorectal disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative metagenomics reveals unique gut microbiome biomarkers in ankylosing spondylitis.
2017Genome biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Quantitative microbiome profiling links gut community variation to microbial load.
2017Nature
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut mucosal-associated microbiota better discloses inflammatory bowel disease differential patterns than faecal microbiota.
2019Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered Gut Microbiota Is Present in Newly Diagnosed Pediatric Patients With Inflammatory Bowel Disease.
2020Journal of pediatric gastroenterology and nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of the Salivary Microbiome During Different Phases of Crohn's Disease.
2020Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary fiber intake, the gut microbiome, and chronic systemic inflammation in a cohort of adult men.
2021Genome medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gastrointestinal microbiome and Helicobacter pylori: Eradicate, leave it as it is, or take a personalized benefit-risk approach?
2022World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Typing of the Gut Microbiota Community in Japanese Subjects.
2022Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Composition of the gut microbiota in patients with inflammatory bowel disease in Saudi Arabia: A pilot study.
2023Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Insight into gut dysbiosis of patients with inflammatory bowel disease and ischemic colitis.
2023Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Deciphering salivary microbiome signature in Crohn's disease patients with different factors contributing to dysbiosis.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exclusive Enteral Nutrition Mediates Beneficial Gut Microbiome Enrichment in Acute Severe Colitis.
2024Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
2024Gene
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Persistent dysbiosis of duodenal microbiota in patients with controlled pediatric Crohn's disease after resolution of inflammation.
2024Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis.
2024Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating Gut Microbiome and Metabolomics with Magnetic Resonance Enterography to Advance Bowel Damage Prediction in Crohn's Disease.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fungal-Bacterial Dysbiosis in IBD: Microbial Biomarkers of Disease Activity.
2025MicrobiologyOpen
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersDysbiosis in a canine model of human fistulizing Crohn's disease.
2020Gut microbes
Human primary paper with plausible association relevance to the disease context.
The basis of antigenic operon fragmentation in Bacteroidota and commensalism.
2023bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.
Preclinical supporting evidence
14 papersSubgingival microflora in inflammatory bowel disease patients with untreated periodontitis.
2013European journal of gastroenterology & hepatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bacterial protein signals are associated with Crohn's disease.
2014Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Critical Role of Intestinal Microbiota in ATF3-Mediated Gut Immune Homeostasis.
2020Journal of immunology (Baltimore, Md. : 1950)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-throughput sequencing provides insights into oral microbiota dysbiosis in association with inflammatory bowel disease.
2021Genomics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Luteolin alleviates inflammation and modulates gut microbiota in ulcerative colitis rats.
2021Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Protective Role of Spermidine in Colitis and Colon Carcinogenesis.
2022Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Functional analysis of metalloenzymes from human gut microbiota and their role in ulcerative colitis.
2023Journal of applied microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiome signatures of Yorkshire Terrier enteropathy during disease and remission.
2023Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Isolation, identification, and significance of salivary Veillonella spp., Prevotella spp., and Prevotella salivae in patients with inflammatory bowel disease.
2023Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut virome-wide association analysis identifies cross-population viral signatures for inflammatory bowel disease.
2024Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mendelian randomization and genetic pleiotropy analysis for the connection between inflammatory bowel disease and Alzheimer's disease.
2025Progress in neuro-psychopharmacology & biological psychiatry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Postbiotic Limosilactobacillus reuteri cultured with Polygonatum kingianum polysaccharides ameliorates high-fat-high-sugar-deteriorated colitis and associated hepatobiliary disorders.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
16 papersDoes our food (environment) change our gut microbiome ('in-vironment'): a potential role for inflammatory bowel disease?
2012Digestive diseases (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Diet, the human gut microbiota, and IBD.
2013Anaerobe
Relevant review or meta-analysis for the signal-disease area.
The gut microbiome.
2014Inflammation & allergy drug targets
Relevant review or meta-analysis for the signal-disease area.
The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn's Disease: A Review.
2017Nutrients
Relevant review or meta-analysis for the signal-disease area.
Smoking and the intestinal microbiome.
2018Archives of microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Prevotella as a possible biomarker of diet and its eubiotic versus dysbiotic roles: a comprehensive literature review.
2019The British journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Oral-Gut Microbiota and Arthritis: Is There an Evidence-Based Axis?
2019Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
The multiple sclerosis gut microbiota: A systematic review.
2020Multiple sclerosis and related disorders
Relevant review or meta-analysis for the signal-disease area.
Influence of Enteral Nutrition on Gut Microbiota Composition in Patients with Crohn's Disease: A Systematic Review.
2020Nutrients
Relevant review or meta-analysis for the signal-disease area.
Modulation of the human gut microbiota by phenolics and phenolic fiber-rich foods.
2020Comprehensive reviews in food science and food safety
Relevant review or meta-analysis for the signal-disease area.
The Gastrointestinal Microbiota of the Common Marmoset (Callithrix jacchus).
2020ILAR journal
Relevant review or meta-analysis for the signal-disease area.
Characteristics of the Gut Bacterial Composition in People of Different Nationalities and Religions.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Microbiome in Hidradenitis Suppurativa-What We Know and Where We Are Heading.
2022International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Anaerobic gut bacteria and their potential role in the initiation, exacerbation, and development of human colorectal cancer: a narrative review.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Bridging the gap: Prevotella/Segatella's impact on gut barrier function and advanced cultivation strategies to realize the uses in gut health.
2026Gut microbes
Relevant review or meta-analysis for the signal-disease area.