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Parabacteroides distasonis

obesity

Parabacteroides distasonis looks like a credible signal in obesity, though some caution is still warranted.

Parabacteroides distasonis shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.

parabacteroides_distasonis
Credibility score
92
Human translation
3/5
Reproducibility
5/5
Novelty
2/5
Actionability
5/5
Credibility 92Human translation 3/5Reproducibility 5/5Novelty 2/5Actionability 5/5
Why this scores the way it does
  • strong central evidence base
  • meaningful supporting human literature
  • substantial preclinical support
Main caveats
  • directionality and confounding still require curated review

Primary central evidence

29 papers
The gut microbial community in metabolic syndrome patients is modified by diet.
2016
The Journal of nutritional biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population.
2016
The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Markers in Obese Adolescent and Adult Patients: Age-Dependent Differential Patterns.
2018
Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis.
2019
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Loss of HDAC6 alters gut microbiota and worsens obesity.
2019
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Discrepant gut microbiota markers for the classification of obesity-related metabolic abnormalities.
2019
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metatranscriptomic analysis to define the Secrebiome, and 16S rRNA profiling of the gut microbiome in obesity and metabolic syndrome of Mexican children.
2020
Microbial cell factories
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Panax notoginseng saponins modulate the gut microbiota to promote thermogenesis and beige adipocyte reconstruction via leptin-mediated AMPKα/STAT3 signaling in diet-induced obesity.
2020
Theranostics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota alterations reveal potential gut-brain axis changes in polycystic ovary syndrome.
2021
Journal of endocrinological investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sex, Food, and the Gut Microbiota: Disparate Response to Caloric Restriction Diet with Fiber Supplementation in Women and Men.
2021
Molecular nutrition & food research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota markers associated with obesity and overweight in Italian adults.
2021
Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior.
2021
Translational psychiatry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Polyclonal Aptamers for Specific Fluorescence Labeling and Quantification of the Health Relevant Human Gut Bacterium Parabacteroides distasonis.
2021
Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the gut microbiota of morbidly obese patients after laparoscopic sleeve gastrectomy.
2022
Future microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of the Gut Microbiota in Individuals with Overweight or Obesity during a Real-World Weight Loss Dietary Program: A Focus on the Bacteroides 2 Enterotype.
2021
Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Low-Carbohydrate Diet and Exercise Training on Gut Microbiota.
2022
Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interplay between dietary intake, gut microbiota, and metabolic profile in obese adolescents: Sex-dependent differential patterns.
2022
Clinical nutrition (Edinburgh, Scotland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota Signature of Obese Adults Across Different Classifications.
2022
Diabetes, metabolic syndrome and obesity : targets and therapy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation.
2023
Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A metagenomic study identifies a Prevotella copri enriched microbial profile associated with non-alcoholic steatohepatitis in subjects with obesity.
2023
Journal of gastroenterology and hepatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intermittent fasting modulates the intestinal microbiota and improves obesity and host energy metabolism.
2023
NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamical alterations of brain function and gut microbiome in weight loss.
2023
Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota: Association with Fiber Intake, Ultra-Processed Food Consumption, Sex, Body Mass Index, and Socioeconomic Status in Medical Students.
2024
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Full-length 16S rRNA Sequencing Reveals Gut Microbiome Signatures Predictive of MASLD in children with obesity.
2025
BMC microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Sex-Specific Effect of a High-Energy Diet on Body Composition, Gut Microbiota, and Inflammatory Markers in Rats.
2025
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Multi-trajectories of BMI, waist circumference, gut microbiota, and incident dyslipidemia: a 27-year prospective study.
2025
mSystems
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Modulation of Gut Microbiota by Whole Encapsulated Brown Seaweed (Himanthalia elongata) in Overweight Subjects: A Randomized Double-Blind Placebo-Controlled Trial.
2025
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Research on the characteristics of gut microbiota in overweight patients with early-onset type 2 diabetes mellitus.
2025
Journal of diabetes investigation
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrated gut microbiota and metabolomic profiling reveals key associations between amino acid levels and gut microbial composition in patients with obesity.
2025
Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

2 papers
Comparing the gut microbiome of obese, African American, older adults with and without mild cognitive impairment.
2023
PloS one
Human primary paper with plausible association relevance to the disease context.
Bacterial strains in the human gut associate with host physiology.
2025
bioRxiv : the preprint server for biology
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

27 papers
Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids.
2019
Cell reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice.
2020
International journal of obesity (2005)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-Fat Diet Alters the Intestinal Microbiota in Streptozotocin-Induced Type 2 Diabetic Mice.
2019
Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Parabacteroides distasonis attenuates tumorigenesis, modulates inflammatory markers and promotes intestinal barrier integrity in azoxymethane-treated A/J mice.
2020
Carcinogenesis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ethanol extract of propolis prevents high-fat diet-induced insulin resistance and obesity in association with modulation of gut microbiota in mice.
2020
Food research international (Ottawa, Ont.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparative study of the anti-obesity and gut microbiota modulation effects of green tea phenolics and their oxidation products in high-fat-induced obese mice.
2022
Food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pomegranate fruit pulp polyphenols reduce diet-induced obesity with modulation of gut microbiota in mice.
2022
Journal of the science of food and agriculture
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Dysbiosis and Altered Bile Acid Catabolism Lead to Metabolic Disorder in Psoriasis Mice.
2022
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Temporal relationship among adiposity, gut microbiota, and insulin resistance in a longitudinal human cohort.
2022
BMC medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Human gut microbiota after bariatric surgery alters intestinal morphology and glucose absorption in mice independently of obesity.
2023
Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Parabacteroides merdae protects against cardiovascular damage by enhancing branched-chain amino acid catabolism.
2022
Nature metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Yeast mannoproteins are expected to be a novel potential functional food for attenuation of obesity and modulation of gut microbiota.
2022
Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Theabrownin inhibits obesity and non-alcoholic fatty liver disease in mice via serotonin-related signaling pathways and gut-liver axis.
2023
Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Characterization of Two Parabacteroides distasonis Candidate Strains as New Live Biotherapeutics against Obesity.
2023
Cells
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of Fat Deposition-Gut Interactions in Obese Mice by Administrating with Nobiletin.
2023
Genes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Metformin targets intestinal immune system signaling pathways in a high-fat diet-induced mouse model of obesity and insulin resistance.
2023
Frontiers in endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Weight Loss Promotion in Individuals with Obesity through Gut Microbiota Alterations with a Multiphase Modified Ketogenic Diet.
2023
Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota changes associated with low-carbohydrate diet intervention for obesity.
2024
Open life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Dysbiosis Shaped by Cocoa Butter-Based Sucrose-Free HFD Leads to Steatohepatitis, and Insulin Resistance in Mice.
2024
Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multi-omics analysis reveals the impact of gut microbiota on antipsychotic-induced weight gain in schizophrenia.
2024
Schizophrenia research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Long-Term Exposure to Polystyrene Microspheres and High-Fat Diet-Induced Obesity in Mice: Evaluating a Role for Microbiota Dysbiosis.
2024
Environmental health perspectives
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oleoylethanolamide-producing Lactobacillus paracasei F19 improves metabolic and behavioral disorders by restoring intestinal permeability and microbiota-gut-brain axis in high-fat diet-induced obese male mice.
2025
Brain, behavior, and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Curcumin mitigates obesity-driven dysbiosis and liver steatosis while promoting browning and thermogenesis in white adipose tissue of high-fat diet-fed mice.
2025
The Journal of nutritional biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Unraveling the Obesity-Combating Potential of Parabacteroides goldsteinii and Bacteroides sartorii: A Dual-Probiotic Approach.
2026
Probiotics and antimicrobial proteins
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Probiotic Parabacteroides johnsonii Ameliorates Metabolic Disorders Through Promoting BCAAs to BSCFAs Conversion.
2025
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Discrepancies in gut microbial communities and serum metabolites of Hu sheep with different backfat thickness.
2025
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid.
2025
Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

7 papers
Intestinal Microbiome Shifts, Dysbiosis, Inflammation, and Non-alcoholic Fatty Liver Disease.
2018
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota and Gestational Diabetes Mellitus: A Review of Host-Gut Microbiota Interactions and Their Therapeutic Potential.
2020
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Patients with Polycystic Ovary Syndrome: a Systematic Review.
2022
Reproductive sciences (Thousand Oaks, Calif.)
Relevant review or meta-analysis for the signal-disease area.
Gut microbes participate in food preference alterations during obesity.
2021
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
The Role of Next-Generation Probiotics in Obesity and Obesity-Associated Disorders: Current Knowledge and Future Perspectives.
2023
International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Gingerols: Preparation, encapsulation, and bioactivities focusing gut microbiome modulation and attenuation of disease symptoms.
2025
Phytomedicine : international journal of phytotherapy and phytopharmacology
Relevant review or meta-analysis for the signal-disease area.
Therapeutic potential of the gut commensal bacterium Parabacteroides goldsteinii in human health and disease treatment.
2025
Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.