preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
fulltophigh inflation risk
Parabacteroides distasonis
crohn's disease
Parabacteroides distasonis has meaningful literature visibility in crohn's disease, but the current evidence mix suggests a substantial risk of overclaiming.
Parabacteroides distasonis shows a strong literature footprint in crohn's disease, with substantial central evidence and broader supporting literature.
parabacteroides_distasonis
Credibility score
69
Human translation
2/5
Reproducibility
5/5
Novelty
3/5
Actionability
5/5
Credibility 69Human translation 2/5Reproducibility 5/5Novelty 3/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
20 papersCharacterization of adherent bacteroidales from intestinal biopsies of children and young adults with inflammatory bowel disease.
2013PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Increase of faecal tryptic activity relates to changes in the intestinal microbiome: analysis of Crohn's disease with a multidisciplinary platform.
2013PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbiota in Health, Diverticular Disease, Irritable Bowel Syndrome, and Inflammatory Bowel Diseases: Time for Microbial Marker of Gastrointestinal Disorders.
2018Digestive diseases (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial dysbiosis in inflammatory bowel diseases: results of a metagenomic study in Saudi Arabia.
2019Minerva gastroenterologica e dietologica
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
TH1 cell-inducing Escherichia coli strain identified from the small intestinal mucosa of patients with Crohn's disease.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Transplant in Two Ulcerative Colitis Pediatric Cases: Gut Microbiota and Clinical Course Correlations.
2020Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Timing of Tributyrin Supplementation Differentially Modulates Gastrointestinal Inflammation and Gut Microbial Recolonization Following Murine Ileocecal Resection.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamic Alteration of the Gut Microbiota Associated with Obesity and Intestinal Inflammation in Ovariectomy C57BL/6 Mice.
2022International journal of endocrinology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of gut microbiome profiles in common marmosets (Callithrix jacchus) in health and intestinal disease.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota in the early stage of Crohn's disease has unique characteristics.
2022Gut pathogens
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Integrating the serum proteomic and fecal metaproteomic to analyze the impacts of overweight/obesity on IBD: a pilot investigation.
2023Clinical proteomics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dynamics of the Gut Mycobiome in Patients With Ulcerative Colitis.
2024Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Serial Fecal Microbiota Infusions via Colonoscopy for Active Ulcerative Colitis: A Feasibility, Safety, and Translational Monocentric Italian Study.
2023Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Early-life gut microbiota in food allergic children and its impact on the development of allergic disease.
2023Italian journal of pediatrics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Assessment of the Inflammatory Effects of Gut Microbiota from Human Twins Discordant for Ulcerative Colitis on Germ-free Mice.
2024Comparative medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Rodent Gut Bacteria Coexisting with an Insect Gut Virus in Tapeworm Parasitic Cysts: Metagenomic Evidence of Microbial Selection in Extra-Intestinal Clinical Niches.
2024Microorganisms
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alterations of the Gut Microbiome and TMAO Levels in Patients with Ulcerative Colitis.
2024Journal of clinical medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Culture-based characterization of gut microbiota in inflammatory bowel disease.
2025Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Mushroom Based Prebiotic Supplement Pilot Study Among Patients with Crohn's Disease.
2025Journal of dietary supplements
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbial Signatures Associated With Clinical Remission in Inflammatory Bowel Disease Treated With Biologics: A Comprehensive Multi-Cohort Analysis.
2025United European gastroenterology journal
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
3 papersComplete Genome Sequence of a Parabacteroides distasonis Strain (CavFT hAR46) Isolated from a Gut Wall-Cavitating Microlesion in a Patient with Severe Crohn's Disease.
2019Microbiology resource announcements
Human primary paper with plausible association relevance to the disease context.
The basis of antigenic operon fragmentation in Bacteroidota and commensalism.
2023bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.
Rodent Gut Bacteria Coexisting with an Insect Gut Virus in Parasitic Cysts: Metagenomic Evidence of Microbial Translocation and Co-adaptation in Spatially-Confined Niches.
2024bioRxiv : the preprint server for biology
Relevant preprint retained as supporting evidence, not central evidence.
Preclinical supporting evidence
28 papersOral administration of Parabacteroides distasonis antigens attenuates experimental murine colitis through modulation of immunity and microbiota composition.
2011Clinical and experimental immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pglyrp-Regulated Gut Microflora Prevotella falsenii, Parabacteroides distasonis and Bacteroides eggerthii Enhance and Alistipes finegoldii Attenuates Colitis in Mice.
2016PloS one
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of IRW and IQW on Oxidative Stress and Gut Microbiota in Dextran Sodium Sulfate-Induced Colitis.
2018Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Modulation of gut microbiota by Ilex kudingcha improves dextran sulfate sodium-induced colitis.
2019Food research international (Ottawa, Ont.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
In Vitro Characterization of Gut Microbiota-Derived Commensal Strains: Selection of Parabacteroides distasonis Strains Alleviating TNBS-Induced Colitis in Mice.
2020Cells
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intratracheally instillated diesel PM2.5 significantly altered the structure and composition of indigenous murine gut microbiota.
2021Ecotoxicology and environmental safety
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Parabacteroides distasonis induces depressive-like behavior in a mouse model of Crohn's disease.
2021Brain, behavior, and immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Long-term exclusive enteral nutrition remodels the gut microbiota and alleviates TNBS-induced colitis in mice.
2022Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The underlying mechanism of A-type procyanidins from peanut skin on DSS-induced ulcerative colitis mice by regulating gut microbiota and metabolism.
2022Journal of food biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Royal Jelly Protected against Dextran-Sulfate-Sodium-Induced Colitis by Improving the Colonic Mucosal Barrier and Gut Microbiota.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nuciferine Regulates Immune Function and Gut Microbiota in DSS-Induced Ulcerative Colitis.
2022Frontiers in veterinary science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Parabacteroides distasonis Properties Linked to the Selection of New Biotherapeutics.
2022Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Polysaccharide from Edible Alga Enteromorpha clathrata Improves Ulcerative Colitis in Association with Increased Abundance of Parabacteroides spp. in the Gut Microbiota of Dextran Sulfate Sodium-Fed Mice.
2022Marine drugs
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Parabacteroides distasonis ameliorates hepatic fibrosis potentially via modulating intestinal bile acid metabolism and hepatocyte pyroptosis in male mice.
2023Nature communications
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Regulation of gut microbiota and alleviation of DSS-induced colitis by vitexin.
2023European journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Clonal Parabacteroides from Gut Microfistulous Tracts as Transmissible Cytotoxic Succinate-Commensal Model of Crohn's Disease Complications.
2024bioRxiv : the preprint server for biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Akkermansia muciniphila and Parabacteroides distasonis synergistically protect from colitis by promoting ILC3 in the gut.
2024mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Integrative analysis with microbial modelling and machine learning uncovers potential alleviators for ulcerative colitis.
2024Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Profile Changes in Patients with Inflammatory Bowel Disease and Non-Alcoholic Fatty Liver Disease: A Metagenomic Study.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Daikenchuto, a Japanese herbal medicine, ameliorates experimental colitis in a murine model by inducing secretory leukocyte protease inhibitor and modulating the gut microbiota.
2024Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbiota-derived IPA alleviates intestinal mucosal inflammation through upregulating Th1/Th17 cell apoptosis in inflammatory bowel disease.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral Sheep Milk-Derived Exosome Therapeutics for Cadmium-Induced Inflammatory Bowel Disease.
2025International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
CD8+ T Cell-Derived Perforin Exacerbates Dysbiosis and Inflammatory Bowel Disease via β-Hydroxybutyrate Suppression in Mouse Colonic Epithelium.
2025Journal of inflammation research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bifidobacterium breve B2798 and Its Heat-Killed Cells Alleviate Inflammation in Rats with DSS Model by Modulating Gut Microbiota.
2025Probiotics and antimicrobial proteins
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Annexin A1 levels affect microbiota in health and DSS-induced colitis/inflammatory bowel disease development.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Parabacteroides goldsteinii mitigates parkinsonism in LRRK2 mutant mice by reducing neuroinflammation through Gut-Brain axis.
2025Journal of advanced research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Interactions between Parabacteroides goldsteinii CCUG 48944 and diet ameliorate colitis in mice via regulating gut bile acid metabolism.
2025iMetaOmics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
4 papersAlterations of the Skin and Gut Microbiome in Psoriasis and Psoriatic Arthritis.
2021International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health.
2021Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Therapeutic potential of Parabacteroides distasonis in gastrointestinal and hepatic disease.
2024MedComm
Relevant review or meta-analysis for the signal-disease area.
Therapeutic potential of the gut commensal bacterium Parabacteroides goldsteinii in human health and disease treatment.
2025Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.