preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Mucin degradation
atopic dermatitis
Mucin degradation has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Mucin degradation shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
mucin_degradation
Credibility score
34
Human translation
2/5
Reproducibility
3/5
Novelty
3/5
Actionability
2/5
Credibility 34Human translation 2/5Reproducibility 3/5Novelty 3/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
8 papersGene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
2010PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Perturbations of gut microbiome genes in infants with atopic dermatitis according to feeding type.
2018The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Pediococcus acidilactici intake decreases the clinical severity of atopic dermatitis along with increasing mucin production and improving the gut microbiome in Nc/Nga mice.
2020Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Microbiota Nutrient Utilization Potential Suggests Mucins as Drivers for Initial Gut Colonization of Mother-Child-Shared Bacteria.
2021Applied and environmental microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The abundance of Ruminococcus bromii is associated with faecal butyrate levels and atopic dermatitis in infancy.
2022Allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Forecasting of Atopic Dermatitis in Newborns.
2022Indian journal of dermatology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Next-Generation Probiotics in Allergy Therapy: Scientific Evidence and Clinical Applications.
2025Anti-inflammatory & anti-allergy agents in medicinal chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Impression cytology in atopic dermatitis.
1998Ophthalmology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
16 papersExpression and function of CD43 and CDw60 on T cells from patients with atopic dermatitis.
2001Acta dermato-venereologica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Genetic association studies between the T cell immunoglobulin mucin (TIM) gene locus and childhood atopic dermatitis.
2006International archives of allergy and immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comparison of gut microbiota and allergic reactions in BALB/c mice fed different cultivars of rice.
2010The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Poikiloderma-like lesions on the neck in atopic dermatitis: a histopathological study.
1990The Journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Norfloxacin, a Fluoroquinolone Antibiotic, Inhibits Langerhans Cell-Mediated Th1 and Th2 Cell Development.
2019Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Clec10a regulates mite-induced dermatitis.
2019Science immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical Application of Doxycycline Inhibits Th2 Cell Development Mediated by Langerhans Cells and Exerts a Therapeutic Effect on Atopic Dermatitis.
2020Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of anti-allergy drugs on Th1 cell and Th2 cell development mediated by Langerhans cells.
2020Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ruminococcus gnavus ameliorates atopic dermatitis by enhancing Treg cell and metabolites in BALB/c mice.
2022Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bee Venom Prevents Mucin 5AC Production through Inhibition of AKT and SPDEF Activation in Airway Epithelia Cells.
2021Toxins
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Galectin-9 contributes to the pathogenesis of atopic dermatitis via T cell immunoglobulin mucin-3.
2022Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dupilumab-associated ocular surface disease in atopic dermatitis patients: Clinical characteristics, ophthalmic treatment response and conjunctival goblet cell analysis.
2023Allergy
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oleoylethanolamide ameliorates allergic asthma and atopic dermatitis via activation of GPR119.
2025International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dupilumab-induced inhibition of myeloid dendritic cell function via TIM-3-TGF-β1 feedback loop in treatment of atopic dermatitis.
2025The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
A Case of Idiopathic Follicular Mucinosis Treated Successfully with Cyclosporine.
2024Acta dermatovenerologica Croatica : ADC
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Targeting Barrier Reinforcement and MAPK Inhibition: Recombinant Mucin-Type Collagen Tandems Ameliorate Inflammation in TNF-α/IFN-γ-Induced Atopic Dermatitis-like HaCaT Keratinocytes.
2026ACS synthetic biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
9 papersTIM-1, a novel allergy and asthma susceptibility gene.
2004Springer seminars in immunopathology
Relevant review or meta-analysis for the signal-disease area.
Mechanisms of Action of Probiotics.
2019Advances in nutrition (Bethesda, Md.)
Relevant review or meta-analysis for the signal-disease area.
Ocular surface disease associated with dupilumab treatment for atopic diseases.
2021The ocular surface
Relevant review or meta-analysis for the signal-disease area.
Atopic dermatitis and ocular allergy: common mechanisms and uncommon questions.
2023Current opinion in allergy and clinical immunology
Relevant review or meta-analysis for the signal-disease area.
Ocular surface disease in moderate-to-severe atopic dermatitis patients and the effect of biological therapy.
2024Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Relevant review or meta-analysis for the signal-disease area.
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.
2024Allergologie select
Relevant review or meta-analysis for the signal-disease area.
Ocular Side Effects of Dupilumab: A Comprehensive Overview of the Literature.
2025Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Galectin-9: diverse roles in skin disease.
2025Frontiers in allergy
Relevant review or meta-analysis for the signal-disease area.
Protein Glycosylation: An Emerging Regulator of Allergic Diseases.
2026Allergy
Relevant review or meta-analysis for the signal-disease area.