Intestinal mycobiome associated with diagnosis of inflammatory bowel disease based on tissue biopsies.
2022Medical mycology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
supportedmidmoderate inflation risk
Malassezia
inflammatory bowel disease
Malassezia is an interesting but still moderate-confidence signal in inflammatory bowel disease.
Malassezia shows a moderate evidence base in inflammatory bowel disease, with multiple central papers and additional supporting literature.
malassezia
Credibility score
23
Human translation
3/5
Reproducibility
3/5
Novelty
3/5
Actionability
2/5
Credibility 23Human translation 3/5Reproducibility 3/5Novelty 3/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
Main caveats
- directionality and confounding still require curated review
Primary central evidence
7 papersMalassezia in Inflammatory Bowel Disease: Accomplice of Evoking Tumorigenesis.
2022Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The ileal fungal microbiota is altered in Crohn's disease and is associated with the disease course.
2022Frontiers in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes in the gut mycobiome in pediatric patients in relation to the clinical activity of Crohn's disease.
2023World journal of gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Characterization of Intestinal Mycobiome in Surgical Resections from Inflammatory Bowel Disease Patients: A Deeper Analysis in Complicated Crohn's Disease Phenotypes.
2025Inflammatory bowel diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosal fungal dysbiosis is associated with early postoperative endoscopic recurrence after bowel resection for Crohn's disease.
2026International journal of colorectal disease
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal Mycobiota in Patients with Inflammatory Bowel Diseases and Extraintestinal Manifestations.
2024Gut microbes reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
5 papersMalassezia Is Associated with Crohn's Disease and Exacerbates Colitis in Mouse Models.
2019Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fungal Dysbiosis Correlates with the Development of Tumor-Induced Cachexia in Mice.
2020Journal of fungi (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multiple Hybridization Events Punctuate the Evolutionary Trajectory of Malassezia furfur.
2022mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Live Malassezia strains from the mucosa of patients with ulcerative colitis: pathogenic potential and environmental adaptations.
2025mBio
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Case Report: Facial Malassezia folliculitis following infliximab treatment in Crohn's disease.
2025Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
5 papersReview article: fungal alterations in inflammatory bowel diseases.
2019Alimentary pharmacology & therapeutics
Relevant review or meta-analysis for the signal-disease area.
Chronic Diseases Associated with Malassezia Yeast.
2021Journal of fungi (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Food Habit Associated Mycobiota Composition and Their Impact on Human Health.
2021Frontiers in nutrition
Relevant review or meta-analysis for the signal-disease area.
Fungal microbiome in inflammatory bowel disease: a critical assessment.
2022The Journal of clinical investigation
Relevant review or meta-analysis for the signal-disease area.
Gut Mycobiome in Inflammatory Bowel Disease: A Systematic Review of Case-Control Studies.
2025Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.