supportedtophigh inflation risk

Malassezia

atopic dermatitis

Malassezia has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.

Malassezia has a broader but less central evidence footprint in atopic dermatitis, with support coming from indirect, review, or preclinical literature.

malassezia

Credibility score

Human translation

2/5

Reproducibility

5/5

Novelty

1/5

Actionability

1/5

Credibility 53Human translation 2/5Reproducibility 5/5Novelty 1/5Actionability 1/5

Why this scores the way it does

meaningful supporting human literature
dense review literature
substantial preclinical support

Main caveats

preclinical evidence outweighs human evidence
review density exceeds central evidence depth
limited central evidence

Internal review flags

2 flags

preclinical_heavy

Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.

review_heavy

Review literature is very dense relative to primary central evidence.

Primary central evidence

4 papers

Malassezia Yeast and Cytokine Gene Polymorphism in Atopic Dermatitis.

2017

Journal of clinical and diagnostic research : JCDR

PMID 28511379 DOI

Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Head and neck dermatitis, a subtype of atopic dermatitis induced by Malassezia spp: Clinical aspects and treatment outcomes in adolescent and adult patients.

2021

Pediatric dermatology

PMID 33155738 DOI

Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Study of Hypersensitivity to Malassezia furfur in Patients with Atopic Dermatitis with Head and Neck Pattern: Is It Useful as a Biomarker and Therapeutic Indicator in These Patients?

2022

Life (Basel, Switzerland)

PMID 35207586 DOI

Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Gut Mycobiome in Atopic Dermatitis and in Overweight Young Children: A Prospective Cohort Study in Finland.

2024

Journal of fungi (Basel, Switzerland)

PMID 38786688 DOI

Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

3 papers

Cutaneous Malassezia microbiota in atopic dermatitis patients differ by gender and body part.

2010

Dermatology (Basel, Switzerland)

PMID 20924162 DOI

Human primary paper with plausible association relevance to the disease context.

Atopic dermatitis from adolescence to adulthood in the TOACS cohort: prevalence, persistence and comorbidities.

2015

Allergy

PMID 25832131 DOI

Human primary paper with plausible association relevance to the disease context.

Skin dysbiosis in the microbiome in atopic dermatitis is site-specific and involves bacteria, fungus and virus.

2021

BMC microbiology

PMID 34551705 DOI

Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

11 papers

[Malassezia and atopic dermatitis].

2003

Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology

PMID 12748585 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Head and neck atopic dermatitis and malassezia-furfur-specific IgE antibodies.

2005

Dermatology (Basel, Switzerland)

PMID 16088155 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Malassezia species dysbiosis in natural and allergen-induced atopic dermatitis in dogs.

2020

Medical mycology

PMID 31782778 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

IgE sensitivity to Malassezia pachydermatis and mite allergens in dogs with atopic dermatitis.

2020

Veterinary immunology and immunopathology

PMID 32492589 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Comparative Analysis of Cutaneous Fungi in Atopic Dermatitis Patients and Healthy Individuals.

2022

Annals of dermatology

PMID 35450318 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

The Acari Hypothesis, III: Atopic Dermatitis.

2022

Pathogens (Basel, Switzerland)

PMID 36297140 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Interactions between Malassezia and New Therapeutic Agents in Atopic Dermatitis Affecting Skin Barrier and Inflammation in Recombinant Human Epidermis Model.

2023

International journal of molecular sciences

PMID 37047166 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

The Skin Mycobiome of Patients With Atopic Dermatitis and Healthy Volunteers: A Case-Control Study.

2025

Experimental dermatology

PMID 40114327 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Effects of Malassezia globosa on the Expression of Thymic Stromal Lymphopoietin and Differentiation of T Helper Cells in MC903-Induced Atopic Dermatitis Mouse Model.

2025

International journal of microbiology

PMID 40309262 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Skin microbiome composition and function in the development of atopic diseases during infancy.

2025

bioRxiv : the preprint server for biology

PMID 41509497 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Preliminary Characterization of Skin Microbiota and Mycobiota in Atopic Dermatitis by Metagenomic and Culture-Based Analyses.

2026

Life (Basel, Switzerland)

PMID 42073497 DOI

Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

41 papers

[Fungi and atopic dermatitis].

1999

Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology

PMID 10234078 DOI