review_heavy
Review literature is very dense relative to primary central evidence.
fulltopmoderate inflation risk
Lipopolysaccharide biosynthesis
obesity
Lipopolysaccharide biosynthesis looks like a credible signal in obesity, though some caution is still warranted.
Lipopolysaccharide biosynthesis shows a strong literature footprint in obesity, with substantial central evidence and broader supporting literature.
lipopolysaccharide_biosynthesis
Credibility score
81
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
5/5
Credibility 81Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 5/5
Why this scores the way it does
- strong central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- retrieval noise or disease-specificity issues may remain
Internal review flags
3 flagshigh_exclusion_volume
Many retrieved papers were excluded. Retrieval may be broad or disease specificity may be noisy.
sparse_primary_supporting_bucket
Central evidence is high but primary supporting bucket is empty. Classification tiers may still be too coarse.
Primary central evidence
23 papersMetabolic network model of a human oral pathogen.
2009Journal of bacteriology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Maternal obesity is associated with gut microbial metabolic potential in offspring during infancy.
2018Journal of physiology and biochemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dysbiosis Signatures of Gut Microbiota Along the Sequence from Healthy, Young Patients to Those with Overweight and Obesity.
2018Obesity (Silver Spring, Md.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions.
2018Experimental & molecular medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Metabolic endotoxemia promotes adipose dysfunction and inflammation in human obesity.
2019American journal of physiology. Endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Obesity and Type 2 Diabetes mellitus induce lipopolysaccharide tolerance in rat neutrophils.
2018Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease.
2019Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
IL-29 promoted obesity-induced inflammation and insulin resistance.
2020Cellular & molecular immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Exercise Training Modulates Gut Microbiota Profile and Improves Endotoxemia.
2020Medicine and science in sports and exercise
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Intermittent Fasting Improves Cardiometabolic Risk Factors and Alters Gut Microbiota in Metabolic Syndrome Patients.
2021The Journal of clinical endocrinology and metabolism
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Korean-Style Balanced Diet Has a Potential Connection with Ruminococcaceae Enterotype and Reduction of Metabolic Syndrome Incidence in Korean Adults.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Biomarkers for assessment of intestinal permeability in clinical practice.
2021American journal of physiology. Gastrointestinal and liver physiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
16S rDNA Full-Length Assembly Sequencing Technology Analysis of Intestinal Microbiome in Polycystic Ovary Syndrome.
2021Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Alleviation of Neuronal Cell Death and Memory Deficit with Chungkookjang Made with Bacillus amyloliquefaciens and Bacillus subtilis Potentially through Promoting Gut-Brain Axis in Artery-Occluded Gerbils.
2021Foods (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Obese Individuals With and Without Phlegm-Dampness Constitution Show Different Gut Microbial Composition Associated With Risk of Metabolic Disorders.
2022Frontiers in cellular and infection microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut-microbiota in children and adolescents with obesity: inferred functional analysis and machine-learning algorithms to classify microorganisms.
2023Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Platelet-derived growth factor signaling in pericytes promotes hypothalamic inflammation and obesity.
2024Molecular medicine (Cambridge, Mass.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer.
2024Cell reports. Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Dysbiosis Linked to Metabolic Dysfunction-Associated Fatty Liver Disease in Asians: Prevotella copri Promotes Lipopolysaccharide Biosynthesis and Network Instability in the Prevotella Enterotype.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Targeting miR-29 mitigates skeletal senescence and bolsters therapeutic potential of mesenchymal stromal cells.
2024Cell reports. Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association between Gut Microbiota Profiles, Dietary Intake, and Inflammatory Markers in Overweight and Obese Women.
2024Foods (Basel, Switzerland)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Visceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia.
2024Microbiome
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Elevated GFI1 in Alveolar Macrophages Suppresses ACOD1 Expression and Exacerbates Lipopolysaccharide-Induced Lung Injury in Obesity.
2025Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
12 papersVariation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans.
2016Cell
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Structural and functional profiles of the gut microbial community in polycystic ovary syndrome with insulin resistance (IR-PCOS): a pilot study.
2019Research in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice.
2018Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study.
2019Nature medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Shenlian (SL) Decoction, a Traditional Chinese Medicine Compound, May Ameliorate Blood Glucose via Mediating the Gut Microbiota in db/db Mice.
2022Journal of diabetes research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Leptin/obR signaling exacerbates obesity-related neutrophilic airway inflammation through inflammatory M1 macrophages.
2023Molecular medicine (Cambridge, Mass.)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intermittent fasting, calorie restriction, and a ketogenic diet improve mitochondrial function by reducing lipopolysaccharide signaling in monocytes during obesity: A randomized clinical trial.
2024Clinical nutrition (Edinburgh, Scotland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Involucrasin B suppresses airway inflammation in obese asthma by inhibiting the TLR4-NF-κB-NLRP3 pathway.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Semaglutide Attenuates Anxious and Depressive-Like Behaviors and Reverses the Cognitive Impairment in a Type 2 Diabetes Mellitus Mouse Model Via the Microbiota-Gut-Brain Axis.
2024Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Capsaicin Reduces Obesity by Reducing Chronic Low-Grade Inflammation.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut Microbiota Modulates Obesity-Associated Skeletal Deterioration Through Macrophage Aging and Grancalcin Secretion.
2025Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
[Composition of gut microbiota and characteristics of virulence factors genes in overweight or obese children and their relationship with liver metabolic inflammation].
2025Zhonghua er ke za zhi = Chinese journal of pediatrics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
29 papersIntestinal microbiota and obesity.
2012Handbook of experimental pharmacology
Relevant review or meta-analysis for the signal-disease area.
A role for whey-derived lactoferrin and immunoglobulins in the attenuation of obesity-related inflammation and disease.
2017Critical reviews in food science and nutrition
Relevant review or meta-analysis for the signal-disease area.
Metabolic endotoxemia with obesity: Is it real and is it relevant?
2016Biochimie
Relevant review or meta-analysis for the signal-disease area.
Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance.
2016Physiology (Bethesda, Md.)
Relevant review or meta-analysis for the signal-disease area.
Endotoxemia-menace, marker, or mistake?
2016Journal of leukocyte biology
Relevant review or meta-analysis for the signal-disease area.
Metabolic endotoxemia and diabetes mellitus: A systematic review.
2017Metabolism: clinical and experimental
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiota and Alzheimer's Disease.
2017Journal of Alzheimer's disease : JAD
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota: Metabolism and perspective in obesity.
2018Gut microbes
Relevant review or meta-analysis for the signal-disease area.
NLRP3 Inflammasome Activation in Adipose Tissues and Its Implications on Metabolic Diseases.
2020International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Therapeutic mechanisms of traditional Chinese medicine to improve metabolic diseases via the gut microbiota.
2021Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Relevant review or meta-analysis for the signal-disease area.
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions.
2020Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Anti-Inflammatory and Immunomodulatory Effects of Probiotics in Gut Inflammation: A Door to the Body.
2021Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Microbiome and osteoarthritis: New insights from animal and human studies.
2021International journal of rheumatic diseases
Relevant review or meta-analysis for the signal-disease area.
The Importance of Food for Endotoxemia and an Inflammatory Response.
2021International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Lipopolysaccharides derived from gram-negative bacterial pool of human gut microbiota promote inflammation and obesity development.
2022International reviews of immunology
Relevant review or meta-analysis for the signal-disease area.
Periodontitis and cardiometabolic disorders: The role of lipopolysaccharide and endotoxemia.
2022Periodontology 2000
Relevant review or meta-analysis for the signal-disease area.
Gut microbes and muscle function: can probiotics make our muscles stronger?
2022Journal of cachexia, sarcopenia and muscle
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota in Ischemic Stroke: Role of Gut Bacteria-Derived Metabolites.
2023Translational stroke research
Relevant review or meta-analysis for the signal-disease area.
Gut barrier dysfunction and endotoxemia in heart failure: A dangerous connubium?
2023American heart journal
Relevant review or meta-analysis for the signal-disease area.
[Diabetes mellitus and the intestinal microbiome].
2023Orvosi hetilap
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, intestinal permeability, and systemic inflammation: a narrative review.
2024Internal and emergency medicine
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in overweight and obesity: crosstalk with adipose tissue.
2024Nature reviews. Gastroenterology & hepatology
Relevant review or meta-analysis for the signal-disease area.
Diet-Induced Gut Dysbiosis and Leaky Gut Syndrome.
2024Journal of microbiology and biotechnology
Relevant review or meta-analysis for the signal-disease area.
The Effect of Enteric-Derived Lipopolysaccharides on Obesity.
2024International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Human Gut Microbiota in Cardiovascular Disease.
2024Comprehensive Physiology
Relevant review or meta-analysis for the signal-disease area.
Microbiota and Lipotoxicity.
2024Advances in experimental medicine and biology
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota and its role in the development of cardiovascular disease.
2025Expert review of cardiovascular therapy
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota: a hidden player in polycystic ovary syndrome.
2025Journal of translational medicine
Relevant review or meta-analysis for the signal-disease area.
The relationship between increased levels of microbiota-derived lipopolysaccharide in obesity and the pathophysiology of neurodegenerative diseases.
2025Microbial pathogenesis
Relevant review or meta-analysis for the signal-disease area.