preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Lipopolysaccharide biosynthesis
colorectal cancer
Lipopolysaccharide biosynthesis has meaningful literature visibility in colorectal cancer, but the current evidence mix suggests a substantial risk of overclaiming.
Lipopolysaccharide biosynthesis shows a moderate evidence base in colorectal cancer, with multiple central papers and additional supporting literature.
lipopolysaccharide_biosynthesis
Credibility score
55
Human translation
2/5
Reproducibility
4/5
Novelty
2/5
Actionability
3/5
Credibility 55Human translation 2/5Reproducibility 4/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
14 papersPotential of fecal microbiota for early-stage detection of colorectal cancer.
2014Molecular systems biology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Mucosa-associated microbiota signature in colorectal cancer.
2017European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Body Composition, Inflammation, and 5-Year Outcomes in Colon Cancer.
2021JAMA network open
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated Fusobacterium nucleatum ssp. animalis.
2021Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Oral and Gut Microbial Carbohydrate-Active Enzymes Landscape in Health and Disease.
2021Frontiers in microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changes of Intestinal Microflora in Colorectal Cancer Patients after Surgical Resection and Chemotherapy.
2022Computational and mathematical methods in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial lipopolysaccharide modulates immune response in the colorectal tumor microenvironment.
2023NPJ biofilms and microbiomes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Bacterial endotoxin lipopolysaccharides regulate gene expression in human colon cancer cells.
2023BMC research notes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial and metabolic profiles unveil mutualistic microbe-microbe interaction in obesity-related colorectal cancer.
2024Cell reports. Medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota in colorectal cancer related to liver metastasis.
2024Chinese journal of cancer research = Chung-kuo yen cheng yen chiu
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fusobacterium nucleatum subsp. nucleatum RadD binds Siglec-7 and inhibits NK cell-mediated cancer cell killing.
2024iScience
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer.
2024Acta pharmaceutica Sinica. B
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lipopolysaccharide Induces Resistance to CAR-T Cell Therapy of Colorectal Cancer Cells through TGF-β-Mediated Stemness Enhancement.
2025Molecular pharmaceutics
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Altered crosstalk of bacterial lipopolysaccharide with immune cells in colorectal cancer compared to paired adjacent intestinal tissue.
2026Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersMulti-kingdom microbial signatures in excess body weight colorectal cancer based on global metagenomic analysis.
2024Communications biology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
18 papersPIK3R3 regulates ZO-1 expression through the NF-kB pathway in inflammatory bowel disease.
2020International immunopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon.
2021Carbohydrate polymers
Disease-relevant preclinical or model-based paper useful as supporting evidence.
High-Fat Diet Promotes Colorectal Tumorigenesis Through Modulating Gut Microbiota and Metabolites.
2022Gastroenterology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ganluyin ameliorates DSS-induced ulcerative colitis by inhibiting the enteric-origin LPS/TLR4/NF-κB pathway.
2022Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Berberine regulates short-chain fatty acid metabolism and alleviates the colitis-associated colorectal tumorigenesis through remodeling intestinal flora.
2022Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Simulating the Effect of Gut Microbiome on Cancer Cell Growth Using a Microfluidic Device.
2023Sensors (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Tumor-targeting engineered probiotic Escherichia coli Nissle 1917 inhibits colorectal tumorigenesis and modulates gut microbiota homeostasis in mice.
2023Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
LITAF inhibits colorectal cancer stemness and metastatic behavior by regulating FOXO1-mediated SIRT1 expression.
2023Clinical & experimental metastasis
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice.
2023Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Alteration of ascending colon mucosal microbiota in patients after cholecystectomy.
2024World journal of gastrointestinal surgery
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Bowel Inflammation and Nutrient Supplementation: Effects of a Fixed Combination of Probiotics, Vitamins, and Herbal Extracts in an In Vitro Model of Intestinal Epithelial Barrier Dysfunction.
2024The Yale journal of biology and medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
TLR Agonist Nano Immune Therapy Clears Peritoneal and Systemic Ovarian Cancer.
2025Advanced healthcare materials
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Comprehensive retrospect and future perspective on bacteriophage and cancer.
2024Virology journal
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Selective expression and significance of ACKR2 in lung aerocytes.
2025Journal for immunotherapy of cancer
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Acyloxyacyl Hydrolase Prevents Colitis and Colitis-Associated Colorectal Cancer by Inactivating Stimulatory LPS in the Intestine.
2025FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sophocarpine suppresses MAPK-mediated inflammation by restoring gut microbiota in colorectal cancer.
2025Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Megasphaera Elesdenii Dysregulates Colon Epithelial Homeostasis, Aggravates Colitis-Associated Tumorigenesis.
2025Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Parasutterella excrementihominis exacerbates experimental colitis and colitis-associated colorectal cancer via pathogenic NETosis activation.
2026Gut
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
13 papersTargeting aberrant colon cancer-specific DNA methylation with lipoteichoic acid-deficient Lactobacillus acidophilus.
2013Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Toll-like receptor signaling in colorectal cancer: carcinogenesis to cancer therapy.
2014World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Pathophysiological mechanisms of death resistance in colorectal carcinoma.
2015World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
The Inhibitory Effect of Gut Microbiota and Its Metabolites on Colorectal Cancer.
2020Journal of microbiology and biotechnology
Relevant review or meta-analysis for the signal-disease area.
The Link Between Bacterial Inflammagens, Leaky Gut Syndrome and Colorectal Cancer.
2021Current medicinal chemistry
Relevant review or meta-analysis for the signal-disease area.
Oral and Gut Microbial Dysbiosis and Non-alcoholic Fatty Liver Disease: The Central Role of Porphyromonas gingivalis.
2022Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
Extracellular vesicles-mediated interaction within intestinal microenvironment in inflammatory bowel disease.
2022Journal of advanced research
Relevant review or meta-analysis for the signal-disease area.
Intestinal phages interact with bacteria and are involved in human diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer.
2023Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Relevant review or meta-analysis for the signal-disease area.
Autophagy in colitis-associated colon cancer: exploring its potential role in reducing initiation and preventing IBD-Related CAC development.
2024Autophagy
Relevant review or meta-analysis for the signal-disease area.
The gut barrier as a gatekeeper in colorectal cancer treatment.
2024Oncotarget
Relevant review or meta-analysis for the signal-disease area.
Integrated oral-gut microbiota therapy: a novel perspective on preventing bacterial translocation for systemic disease management.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
The Oral-Gut Microbiota Axis Across the Lifespan: New Insights on a Forgotten Interaction.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.