preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedmidhigh inflation risk
Lipopolysaccharide biosynthesis
atopic dermatitis
Lipopolysaccharide biosynthesis has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Lipopolysaccharide biosynthesis shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
lipopolysaccharide_biosynthesis
Credibility score
36
Human translation
1/5
Reproducibility
4/5
Novelty
3/5
Actionability
2/5
Credibility 36Human translation 1/5Reproducibility 4/5Novelty 3/5Actionability 2/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
1 flagsPrimary central evidence
6 papersAdditive effect between IL-13 polymorphism and cesarean section delivery/prenatal antibiotics use on atopic dermatitis: a birth cohort study (COCOA).
2014PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes.
2016Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
High level of fecal calprotectin at age 2 months as a marker of intestinal inflammation predicts atopic dermatitis and asthma by age 6.
2015Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A compromised developmental trajectory of the infant gut microbiome and metabolome in atopic eczema.
2020Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A physiologically relevant culture platform for long-term studies of in vitro gingival tissue.
2023Acta biomaterialia
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis.
2024Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
4 papersExpression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic dermatitis.
2001The Journal of allergy and clinical immunology
Human primary paper with plausible association relevance to the disease context.
Impaired TLR-2 expression and TLR-2-mediated cytokine secretion in macrophages from patients with atopic dermatitis.
2009Allergy
Human primary paper with plausible association relevance to the disease context.
Association of maternal allergy with human milk soluble CD14 and fatty acids, and early childhood atopic dermatitis.
2019Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Human primary paper with plausible association relevance to the disease context.
The Effect of Lipopolysaccharide-containing Moisturizing Cream on Skin Care in Patients With Mild Atopic Dermatitis.
2019In vivo (Athens, Greece)
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
22 papersThe mechanism of a defective IFN-gamma response to bacterial toxins in an atopic dermatitis model, NC/Nga mice, and the therapeutic effect of IFN-gamma, IL-12, or IL-18 on dermatitis.
2001Journal of immunology (Baltimore, Md. : 1950)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Increased secretion of IL-18 in vitro by peripheral blood mononuclear cells of patients with bronchial asthma and atopic dermatitis.
2001Clinical and experimental immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Increased lipopolysaccharide-induced tumour necrosis factor-alpha, interferon-gamma and interleukin-10 production in atopic dermatitis.
2007The British journal of dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intrinsic alterations of pro-inflammatory mediators in unstimulated and TLR-2 stimulated keratinocytes from atopic dermatitis patients.
2011Experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Soluble CD14 concentration in human breast milk and its potential role in child atopic dermatitis: Results of the Ulm Birth Cohort Studies.
2019Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Cationic Amphipathic Triazines with Potent Anti-bacterial, Anti-inflammatory and Anti-atopic Dermatitis Properties.
2019Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
JAK1/2 inhibition impairs the development and function of inflammatory dendritic epidermal cells in atopic dermatitis.
2021The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Efficacy and action mechanisms of a Chinese herbal formula on experimental models of atopic dermatitis.
2021Journal of ethnopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Glabridin attenuates atopic dermatitis progression through downregulating the TLR4/MyD88/NF-κB signaling pathway.
2021Genes & genomics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Single-cell analysis of human skin identifies CD14+ type 3 dendritic cells co-producing IL1B and IL23A in psoriasis.
2021The Journal of experimental medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Different molecular weight hyaluronic acid alleviates inflammation response in DNFB-induced mice atopic dermatitis and LPS-induced RAW 264.7 cells.
2022Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Sopoongsan on Skin Inflammation and Hyperlocomotion in Socially Isolated Mice with Atopic Dermatitis.
2022Evidence-based complementary and alternative medicine : eCAM
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pear pomace alleviated atopic dermatitis in NC/Nga mice and inhibited LPS-induced inflammation in RAW 264.7 macrophages.
2022Nutrition research and practice
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Nepetin Attenuates Atopic Dermatitis in HaCaT Cells and BALB/c Mice through MyD88-MKK3/6-Akt Signaling.
2025Current medicinal chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
In Vitro Anti-Inflammatory and Skin Protective Effects of Codium fragile Extract on Macrophages and Human Keratinocytes in Atopic Dermatitis.
2024Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis.
2024Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Sophoricoside ameliorates methicillin-resistant Staphylococcus aureus-induced acute lung injury by inhibiting Bach1/Akt pathway.
2024Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice.
2024Journal of integrative medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Houttuynia cordata polysaccharides ameliorate atopic dermatitis in mice through modulation of skin immune barrier and lipid metabolism.
2025International journal of biological macromolecules
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Enhanced procoagulant activity of mononuclear leukocytes in patients with atopic dermatitis and psoriasis.
1993Archives of dermatological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
PPD and mitogen responsiveness of lymphocytes from patients with atopic dermatitis.
1977Clinical and experimental immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Milk-responsive atopic dermatitis is associated with a casein-specific lymphocyte response in adolescent and adult patients.
1997The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
7 papersInnate immune defects in atopic dermatitis.
2006The Journal of allergy and clinical immunology
Relevant review or meta-analysis for the signal-disease area.
Bioactives from probiotics for dermal health: functions and benefits.
2013Journal of applied microbiology
Relevant review or meta-analysis for the signal-disease area.
Non-IgE-related diagnostic methods (LST, patch test).
2015Chemical immunology and allergy
Relevant review or meta-analysis for the signal-disease area.
The Role of Dust Mites in Allergy.
2019Clinical reviews in allergy & immunology
Relevant review or meta-analysis for the signal-disease area.
Medicinal potential of Panax ginseng and its ginsenosides in atopic dermatitis treatment.
2020Journal of ginseng research
Relevant review or meta-analysis for the signal-disease area.
Human Milk Bioactive Compounds and Allergic- and Infectious-Related Infant Outcomes: A Systematic Review.
2026Molecular nutrition & food research
Relevant review or meta-analysis for the signal-disease area.
Atopic dermatitis: Multi-omics insights into microbiota-driven modulation of the gut-skin axis.
2026Microbial pathogenesis
Relevant review or meta-analysis for the signal-disease area.