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Lactobacillus

obesity

Lactobacillus has meaningful literature visibility in obesity, but the current evidence mix suggests a substantial risk of overclaiming.

Lactobacillus shows a moderate evidence base in obesity, with multiple central papers and additional supporting literature.

lactobacillus
Credibility score
72
Human translation
2/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 72Human translation 2/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
  • moderate central evidence base
  • dense review literature
  • substantial preclinical support
Main caveats
  • preclinical evidence outweighs human evidence

Internal review flags

2 flags
preclinical_heavy

Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.

review_heavy

Review literature is very dense relative to primary central evidence.

Primary central evidence

13 papers
Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity.
2013
Proceedings of the National Academy of Sciences of the United States of America
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lactobacillus paracasei HII01, xylooligosaccharides, and synbiotics reduce gut disturbance in obese rats.
2018
Nutrition (Burbank, Los Angeles County, Calif.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effects of Synbiotic Supplement on Human Gut Microbiota, Body Composition and Weight Loss in Obesity.
2020
Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbiota engraftment after faecal microbiota transplantation in obese subjects with type 2 diabetes: a 24-week, double-blind, randomised controlled trial.
2022
Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Self-organized metabotyping of obese individuals identifies clusters responding differently to bariatric surgery.
2023
PloS one
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Resynchronized rhythmic oscillations of gut microbiota drive time-restricted feeding induced nonalcoholic steatohepatitis alleviation.
2023
Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
IMMUNOLOGICAL DISORDERS AND COLON DYSBIOSIS IN OBESE PATIENTS WITH HYPOTHYROIDISM.
2023
Wiadomosci lekarskie (Warsaw, Poland : 1960)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Lactobacillus plantarum NCHBL-004 modulates high-fat diet-induced weight gain and enhances GLP-1 production for blood glucose regulation.
2024
Nutrition (Burbank, Los Angeles County, Calif.)
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
An Analysis of the Digestive and Reproductive Tract Microbiota in Infertile Women with Obesity.
2024
International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Study the effect of Lactobacillus plantarum ATCC 14917 for caries prevention and anti-obesity.
2024
Frontiers in nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of gut microbiota with overweight/obesity combined with gestational diabetes mellitus.
2025
Journal of medical microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Comparing the effects of yogurt containing Akkermansia muciniphilia postbiotic with yogurt containing Lactobacillus rhamnosus postbiotic on body composition, biochemical indices, appetite, and depression scores in overweight or obese adults: A randomized, double-blind, controlled clinical trial.
2025
Clinical nutrition ESPEN
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Relationships among host genetics, gut microbiota, and asthma in US Hispanic/Latino adults.
2025
Nature communications
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.

Supporting primary evidence

1 papers
Effects of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 on Overweight and the Gut Microbiota in Humans: Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.
2022
Nutrients
Human primary paper with plausible association relevance to the disease context.

Preclinical supporting evidence

16 papers
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice.
2008
Diabetes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus acidophilus NS1 attenuates diet-induced obesity and fatty liver.
2018
The Journal of endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Microbial dysbiosis-induced obesity: role of gut microbiota in homoeostasis of energy metabolism.
2020
The British journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Subgingival microbiota in overweight and obese young adults with no destructive periodontal disease.
2021
Journal of periodontology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Dietary betaine prevents obesity through gut microbiota-drived microRNA-378a family.
2021
Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability.
2022
Pharmacological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Profiles of gut microbiota in obese-insulin-resistant rats treated with biotics.
2022
European journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Morchella esculenta polysaccharide attenuate obesity, inflammation and modulate gut microbiota.
2022
AMB Express
Disease-relevant preclinical or model-based paper useful as supporting evidence.
An early-life microbiota metabolite protects against obesity by regulating intestinal lipid metabolism.
2023
Cell host & microbe
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption.
2024
Nature metabolism
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Multiomics reveals the ameliorating effect and underlying mechanism of aqueous extracts of polygonatum sibiricum rhizome on obesity and liver fat accumulation in high-fat diet-fed mice.
2024
Phytomedicine : international journal of phytotherapy and phytopharmacology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus paragasseri SBT2055 attenuates obesity via the adipose tissue-muscle-gut axis in obese mice.
2025
Microbiological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Engineered commensals for targeted nose-to-brain drug delivery.
2025
Cell
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus johnsonii-derived leucic acid promotes fatty acid absorption and deposition by targeting CD36.
2025
Science China. Life sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Quercetin ameliorates obesity and inflammation via microbial metabolite indole-3-propionic acid in high fat diet-induced obese mice.
2025
Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus rhamnosus GG attenuates MASLD/MASH progression by modulating gut microbiota and metabolic pathways.
2025
Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.

Review supporting evidence

39 papers
Microecology, obesity, and probiotics.
2008
Current opinion in endocrinology, diabetes, and obesity
Relevant review or meta-analysis for the signal-disease area.
Carbohydrates and the human gut microbiota.
2013
Current opinion in clinical nutrition and metabolic care
Relevant review or meta-analysis for the signal-disease area.
The development of probiotic treatment in obesity: a review.
2014
Beneficial microbes
Relevant review or meta-analysis for the signal-disease area.
Probiotics: an update.
2015
Jornal de pediatria
Relevant review or meta-analysis for the signal-disease area.
The infant gut microbiome: evidence for obesity risk and dietary intervention.
2015
Nutrients
Relevant review or meta-analysis for the signal-disease area.
The Role of Probiotics on the Microbiota: Effect on Obesity.
2016
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition
Relevant review or meta-analysis for the signal-disease area.
Weight gain by gut microbiota manipulation in productive animals.
2017
Microbial pathogenesis
Relevant review or meta-analysis for the signal-disease area.
Evidence of the Anti-Inflammatory Effects of Probiotics and Synbiotics in Intestinal Chronic Diseases.
2017
Nutrients
Relevant review or meta-analysis for the signal-disease area.
The human gut microbiota: Metabolism and perspective in obesity.
2018
Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Probiotic Species in the Modulation of Gut Microbiota: An Overview.
2018
BioMed research international
Relevant review or meta-analysis for the signal-disease area.
Role of prebiotics in regulation of microbiota and prevention of obesity.
2018
Food research international (Ottawa, Ont.)
Relevant review or meta-analysis for the signal-disease area.
Relationship between fatty acids intake and Clostridium coccoides in obese individuals with metabolic syndrome.
2018
Food research international (Ottawa, Ont.)
Relevant review or meta-analysis for the signal-disease area.
Is It Time to Use Probiotics to Prevent or Treat Obesity?
2018
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Probiotics: How Effective Are They in the Fight against Obesity?
2019
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Thylakoids: A Novel Food-Derived Supplement for Obesity - A Mini-Review.
2020
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition
Relevant review or meta-analysis for the signal-disease area.
Immunonutritional contribution of gut microbiota to fatty liver disease.
2020
Nutricion hospitalaria
Relevant review or meta-analysis for the signal-disease area.
Profile of the gut microbiota of adults with obesity: a systematic review.
2020
European journal of clinical nutrition
Relevant review or meta-analysis for the signal-disease area.
Probiotics, Prebiotics, Synbiotics, Postbiotics, and Obesity: Current Evidence, Controversies, and Perspectives.
2020
Current obesity reports
Relevant review or meta-analysis for the signal-disease area.
Probiotics for the Treatment of Overweight and Obesity in Humans-A Review of Clinical Trials.
2020
Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Effects of Probiotics and Synbiotics on Weight Loss in Subjects with Overweight or Obesity: A Systematic Review.
2021
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Human microbiome and metabolic health: An overview of systematic reviews.
2022
Obesity reviews : an official journal of the International Association for the Study of Obesity
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in patients with obesity and metabolic disorders - a systematic review.
2022
Genes & nutrition
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: Therapeutic Targets of Ginseng Against Multiple Disorders and Ginsenoside Transformation.
2022
Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Elucidation of Prebiotics, Probiotics, Postbiotics, and Target from Gut Microbiota to Alleviate Obesity via Network Pharmacology Study.
2022
Cells
Relevant review or meta-analysis for the signal-disease area.
Gut microbiome and human health: Exploring how the probiotic genus Lactobacillus modulate immune responses.
2022
Frontiers in pharmacology
Relevant review or meta-analysis for the signal-disease area.
Vaginal microbiome in obesity and its impact on reproduction.
2023
Best practice & research. Clinical obstetrics & gynaecology
Relevant review or meta-analysis for the signal-disease area.
The Interplay between Medical Plants and Gut Microbiota in Cancer.
2023
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Prebiotics, Probiotics, and Synbiotics-A Research Hotspot for Pediatric Obesity.
2023
Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Understanding how pre- and probiotics affect the gut microbiome and metabolic health.
2024
American journal of physiology. Endocrinology and metabolism
Relevant review or meta-analysis for the signal-disease area.
Male Tract Microbiota and Male Infertility.
2024
Cells
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota Regulation by Acupuncture and Moxibustion: A Systematic Review and Meta-Analysis.
2024
The American journal of Chinese medicine
Relevant review or meta-analysis for the signal-disease area.
Exploration of the Muribaculaceae Family in the Gut Microbiota: Diversity, Metabolism, and Function.
2024
Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut-Brain Axis: Role of Microbiome, Metabolomics, Hormones, and Stress in Mental Health Disorders.
2024
Cells
Relevant review or meta-analysis for the signal-disease area.
The anti-obesity effects of postbiotics: A systematic review of pre-clinical and clinical studies.
2024
Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
Impact of vaginal seeding on the gut microbiome of infants born via cesarean section: A systematic review.
2024
The Journal of infection
Relevant review or meta-analysis for the signal-disease area.
Probiotic, Postbiotic, and Paraprobiotic Effects of Lactobacillus rhamnosus as a Modulator of Obesity-Associated Factors.
2024
Foods (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota: An Important Participant in Childhood Obesity.
2025
Advances in nutrition (Bethesda, Md.)
Relevant review or meta-analysis for the signal-disease area.
Efficacy of microbiome-targeted interventions in obesity management- A comprehensive systematic review.
2025
Diabetes & metabolic syndrome
Relevant review or meta-analysis for the signal-disease area.
The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.
2025
World journal of microbiology & biotechnology
Relevant review or meta-analysis for the signal-disease area.