preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Lactobacillus
atopic dermatitis
Lactobacillus has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Lactobacillus shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
lactobacillus
Credibility score
66
Human translation
2/5
Reproducibility
5/5
Novelty
2/5
Actionability
3/5
Credibility 66Human translation 2/5Reproducibility 5/5Novelty 2/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- meaningful supporting human literature
- dense review literature
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
2 flagsreview_heavy
Review literature is very dense relative to primary central evidence.
Primary central evidence
13 papersInteraction of orally administered Lactobacillus rhamnosus GG with skin and gut microbiota and humoral immunity in infants with atopic dermatitis.
2011Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Probiotics reduce gut microbial translocation and improve adult atopic dermatitis.
2012Journal of clinical gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Children with atopic dermatitis show clinical improvement after Lactobacillus exposure.
2015Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture.
2019Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Probiotics modulate the gut microbiota composition and immune responses in patients with atopic dermatitis: a pilot study.
2020European journal of nutrition
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota of children with atopic dermatitis: Controlled study in the metropolitan region of São Paulo, Brazil.
2020Allergologia et immunopathologia
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Nutrition and Atopic Dermatitis.
2021Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Combined Analysis of Gut and Skin Microbiota in Infants with Food Allergy and Atopic Dermatitis: A Pilot Study.
2021Nutrients
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Effect of a Novel E3 Probiotics Formula on the Gut Microbiome in Atopic Dermatitis Patients: A Pilot Study.
2022Biomedicines
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dietary Galacto-oligosaccharides Ameliorate Atopic Dermatitis-like Skin Inflammation and Behavioral Deficits by Modulating Gut Microbiota-Brain-Skin Axis.
2024Journal of agricultural and food chemistry
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal bacterial microbiota diversity characterized for dogs with atopic dermatitis: its alteration and clinical recovery after meat-exclusion diet.
2025American journal of veterinary research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Limosilactobacillus reuteri CCFM1040 extracellular vesicles alleviate atopic dermatitis through signal transducer and activator of transcription STAT3-dependent modulation of epithelial cytokine.
2025International journal of biological macromolecules
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Immunomodulatory and anti-inflammatory effects of agave fructans in atopic dermatitis: gut microbiota and short-chain fatty acid implication.
2025Frontiers in immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
2 papersUse of probiotics in atopic dermatitis.
2018Revista da Associacao Medica Brasileira (1992)
Human primary paper with plausible association relevance to the disease context.
Multi-omics analyses reveal interactions between the skin microbiota and skin metabolites in atopic dermatitis.
2024Frontiers in microbiology
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
23 papersProbiotics for photoprotection.
2009Dermato-endocrinology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Efficacy of prolonged ingestion of Lactobacillus acidophilus L-92 in adult patients with atopic dermatitis.
2016Journal of dairy science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial.
2018JAMA dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus plantarum-derived Extracellular Vesicles Protect Atopic Dermatitis Induced by Staphylococcus aureus-derived Extracellular Vesicles.
2018Allergy, asthma & immunology research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus sakei WIKIM30 Ameliorates Atopic Dermatitis-Like Skin Lesions by Inducing Regulatory T Cells and Altering Gut Microbiota Structure in Mice.
2018Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral Administration of β-Glucan and Lactobacillus plantarum Alleviates Atopic Dermatitis-Like Symptoms.
2019Journal of microbiology and biotechnology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Administration of Lactobacillus fermentum KBL375 Causes Taxonomic and Functional Changes in Gut Microbiota Leading to Improvement of Atopic Dermatitis.
2019Frontiers in molecular biosciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effects of Lactobacillus pentosus in Children with Allergen-Sensitized Atopic Dermatitis.
2020Journal of Korean medical science
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus paracasei KBL382 administration attenuates atopic dermatitis by modulating immune response and gut microbiota.
2020Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Effectiveness of Probiotic Lactobacillus rhamnosus and Lactobacillus casei Strains in Children with Atopic Dermatitis and Cow's Milk Protein Allergy: A Multicenter, Randomized, Double Blind, Placebo Controlled Study.
2021Nutrients
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Prevention of Atopic Dermatitis in Mice by Lactobacillus Reuteri Fn041 Through Induction of Regulatory T Cells and Modulation of the Gut Microbiota.
2022Molecular nutrition & food research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Efficacy of Probiotics in Children and Adolescents With Atopic Dermatitis: A Randomized, Double-Blind, Placebo-Controlled Study.
2021Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Randomized double-blind placebo-controlled clinical trial to evaluate the effect of a mixture of probiotic strains on symptom severity and use of corticosteroids in children and adolescents with atopic dermatitis.
2023Clinical and experimental dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Clinical effects of combined Lactobacillus paracasei and kestose on canine atopic dermatitis.
2023Polish journal of veterinary sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Exploring Longitudinal Gut Microbiome towards Metabolic Functional Changes Associated in Atopic Dermatitis in Early Childhood.
2023Biology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Improvements in Gut Microbiome Composition Predict the Clinical Efficacy of a Novel Synbiotics Formula in Children with Mild to Moderate Atopic Dermatitis.
2023Microorganisms
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ginsenoside F2-Mediated Intestinal Microbiota and Its Metabolite Propionic Acid Positively Impact the Gut-Skin Axis in Atopic Dermatitis Mice.
2024Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus acidophilus KBL409 Ameliorates Atopic Dermatitis in a Mouse Model.
2024Journal of microbiology (Seoul, Korea)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota profile and atopic dermatitis in the first year of life.
2024Journal of medicine and life
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Exploring Protein Functions of Gut Bacteriome and Mycobiome in Thai Infants Associated with Atopic Dermatitis Through Metaproteomic and Host Interaction Analysis.
2024International journal of molecular sciences
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Topical administration of coumarin derivatives alleviates skin inflammatory symptoms in atopic dermatitis model.
2025Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ligilactobacillus salivarius Lac45 inhibits MRSA and suppresses inflammation in human keratinocyte.
2025Archives of dermatological research
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Lactobacillus crispatus KBL693 alleviates atopic dermatitis symptoms through immune modulation.
2025Journal of microbiology (Seoul, Korea)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
26 papersPediatric applications of inulin and oligofructose.
2007The Journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis.
2008The Journal of allergy and clinical immunology
Relevant review or meta-analysis for the signal-disease area.
Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials.
2008American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
Probiotics.
2008American family physician
Relevant review or meta-analysis for the signal-disease area.
Probiotics and prebiotics in atopic dermatitis: review of the theoretical background and clinical evidence.
2010Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Relevant review or meta-analysis for the signal-disease area.
Prebiotics and probiotics: the prevention and reduction in severity of atopic dermatitis in children.
2014Beneficial microbes
Relevant review or meta-analysis for the signal-disease area.
Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies.
2015Journal of the European Academy of Dermatology and Venereology : JEADV
Relevant review or meta-analysis for the signal-disease area.
Probiotics in the treatment and prevention of allergies in children.
2011Bioscience and microflora
Relevant review or meta-analysis for the signal-disease area.
Applications and safety considerations of Lactobacillus salivarius as a probiotic in animal and human health.
2017Journal of applied microbiology
Relevant review or meta-analysis for the signal-disease area.
Treatment efficacy of probiotics on atopic dermatitis, zooming in on infants: a systematic review and meta-analysis.
2018International journal of dermatology
Relevant review or meta-analysis for the signal-disease area.
An approach on the potential use of probiotics in the treatment of skin conditions: acne and atopic dermatitis.
2018International journal of dermatology
Relevant review or meta-analysis for the signal-disease area.
Probiotics for treating eczema.
2018The Cochrane database of systematic reviews
Relevant review or meta-analysis for the signal-disease area.
Approach to probiotics in pediatrics: the role of Lactobacillus rhamnosus GG.
2022Archivos argentinos de pediatria
Relevant review or meta-analysis for the signal-disease area.
Lactobacillus rhamnosus Used in the Perinatal Period for the Prevention of Atopic Dermatitis in Infants: A Systematic Review and Meta-Analysis of Randomized Trials.
2022American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
Does kimchi deserve the status of a probiotic food?
2024Critical reviews in food science and nutrition
Relevant review or meta-analysis for the signal-disease area.
Lactobacillus for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence.
2023Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Meta-analysis on preventive and therapeutic effects of probiotic supplementation in infant atopic dermatitis.
2023Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
Relevant review or meta-analysis for the signal-disease area.
Oral postbiotics derived from Lactobacillus sp. in treatment of atopic dermatitis: a meta-analysis.
2023Acta dermatovenerologica Alpina, Pannonica, et Adriatica
Relevant review or meta-analysis for the signal-disease area.
In Vivo Functional Properties of Dairy Bacteria.
2023Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Next-Gen biotherapeutics: A systematic review and network meta-analysis on postbiotics as treatment for pediatric atopic dermatitis.
2023Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Relevant review or meta-analysis for the signal-disease area.
Clinical Efficacy of Nutritional Supplements in Atopic Dermatitis: Systematic Review.
2023JMIR dermatology
Relevant review or meta-analysis for the signal-disease area.
Examining the Efficacy of Five Lactobacillus Species in Treating and Preventing Atopic Dermatitis: A Systemic Literature Review.
2024Cureus
Relevant review or meta-analysis for the signal-disease area.
Gut Dysbiosis and Adult Atopic Dermatitis: A Systematic Review.
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
Skin Microbiota: Mediator of Interactions Between Metabolic Disorders and Cutaneous Health and Disease.
2025Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Infant gut microbiota and functional foods: Opportunities for early health intervention.
2025Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
From Gut Dysbiosis to Skin Inflammation in Atopic Dermatitis: Probiotics and the Gut-Skin Axis-Clinical Outcomes and Microbiome Implications.
2025International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.