preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
supportedtophigh inflation risk
Intestinal permeability
atopic dermatitis
Intestinal permeability has meaningful literature visibility in atopic dermatitis, but the current evidence mix suggests a substantial risk of overclaiming.
Intestinal permeability shows a moderate evidence base in atopic dermatitis, with multiple central papers and additional supporting literature.
intestinal_permeability
Credibility score
63
Human translation
2/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 63Human translation 2/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- preclinical evidence outweighs human evidence
Internal review flags
2 flagsreview_heavy
Review literature is very dense relative to primary central evidence.
Primary central evidence
10 papersProbiotics and atopic dermatitis. A new strategy in atopic dermatitis.
2002Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Changing of fecal flora and clinical effect of L. salivarius LS01 in adults with atopic dermatitis.
2012Journal of clinical gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
High dietary fat intake induces a microbiota signature that promotes food allergy.
2019The Journal of allergy and clinical immunology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Nutrition and Atopic Dermatitis.
2021Journal of Nippon Medical School = Nippon Ika Daigaku zasshi
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut microbiota and atopic dermatitis: a two-sample Mendelian randomization study.
2023Frontiers in medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Association of breast milk-derived arachidonic acid-induced infant gut dysbiosis with the onset of atopic dermatitis.
2024Gut
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Evaluation of Intestinal Permeability Using Serum Biomarkers in Learning Early About Peanut Allergy Trial.
2025Allergy
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Aeroportia and pneumatosis intestinalis in infants with food protein-induced-allergic proctocolitis: A presentation of two cases.
2025JPGN reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Severity of atopic dermatitis is associated with gut-derived metabolites and leaky gut-related biomarkers.
2025Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
[Evaluation of biomarkers of intestinal permeability and inflammation in food allergies].
2025Voprosy pitaniia
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersAssessment of Selected Intestinal Permeability Markers in Children with Food Allergy Depending on the Type and Severity of Clinical Symptoms.
2022Nutrients
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
20 papersLow-salt water reduces intestinal permeability in atopic patients.
1999Dermatology (Basel, Switzerland)
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis.
2004The Journal of pediatrics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intestinal permeability, atopic eczema and oral disodium cromoglycate.
1991La Pediatria medica e chirurgica : Medical and surgical pediatrics
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Food-induced alterations of intestinal permeability in children with cow's milk-sensitive enteropathy and atopic dermatitis.
1989Journal of pediatric gastroenterology and nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
PROBIOTICS AND ALLERGIC RESPIRATORY DISEASES.
2015Journal of biological regulators and homeostatic agents
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial.
2018JAMA dermatology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Pancreatic Enzyme Supplementation in Patients with Atopic Dermatitis and Food Allergies: An Open-Label Pilot Study.
2019Paediatric drugs
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion.
2019Immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Kefir and the Gut-Skin Axis.
2022International journal of environmental research and public health
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Succinate and mitochondrial DNA trigger atopic march from atopic dermatitis to intestinal inflammation.
2023The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ginsenoside F2-Mediated Intestinal Microbiota and Its Metabolite Propionic Acid Positively Impact the Gut-Skin Axis in Atopic Dermatitis Mice.
2024Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Role of gut-derived bacterial lipopolysaccharide and peripheral TLR4 in immobilization stress-induced itch aggravation in a mouse model of atopic dermatitis.
2024Scientific reports
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Imidazole propionate ameliorates atopic dermatitis-like skin lesions by inhibiting mitochondrial ROS and mTORC2.
2024Frontiers in immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice.
2024Journal of integrative medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Melatonin treatment increases skin microbiota-derived propionic acid to alleviate atopic dermatitis.
2025The Journal of allergy and clinical immunology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbiota profile and atopic dermatitis in the first year of life.
2024Journal of medicine and life
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The changes of intestinal flora and metabolites in atopic dermatitis mice.
2024Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
2'-FL and cross-feeding bifidobacteria reshaped the gut microbiota of infants with atopic dermatitis ex vivo and prevented dermatitis in mice post-microbiota transplantation through retinol metabolism activation.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Extracellular vesicles of Limosilactobacillus fermentum SLAM216 ameliorate skin symptoms of atopic dermatitis by regulating gut microbiome on serotonin metabolism.
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis.
2025Immunity
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
34 papers[Ciclosporin].
2002Annales de dermatologie et de venereologie
Relevant review or meta-analysis for the signal-disease area.
The role of probiotics in the clinical management of food allergy and atopic dermatitis.
2004Journal of clinical gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Probiotics in the atopic march: highlights and new insights.
2006Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Relevant review or meta-analysis for the signal-disease area.
Pediatric applications of inulin and oligofructose.
2007The Journal of nutrition
Relevant review or meta-analysis for the signal-disease area.
The role of food allergy in atopic dermatitis.
2008Current allergy and asthma reports
Relevant review or meta-analysis for the signal-disease area.
[Intestinal permeability disorders in children].
1991Allergie et immunologie
Relevant review or meta-analysis for the signal-disease area.
Basophils in inflammation.
2016European journal of pharmacology
Relevant review or meta-analysis for the signal-disease area.
Atopic dermatitis and the intestinal microbiota in humans and dogs.
2016Veterinary medicine and science
Relevant review or meta-analysis for the signal-disease area.
Skin neurogenic inflammation.
2018Seminars in immunopathology
Relevant review or meta-analysis for the signal-disease area.
The Gut Microbiome as a Major Regulator of the Gut-Skin Axis.
2018Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Mechanisms of Action of Probiotics.
2019Advances in nutrition (Bethesda, Md.)
Relevant review or meta-analysis for the signal-disease area.
Prebiotics and probiotics in atopic dermatitis.
2019Experimental and therapeutic medicine
Relevant review or meta-analysis for the signal-disease area.
The Microbiome and Atopic Dermatitis: A Review.
2019American journal of clinical dermatology
Relevant review or meta-analysis for the signal-disease area.
Gut Microbiota, Probiotics, and Their Interactions in Prevention and Treatment of Atopic Dermatitis: A Review.
2021Frontiers in immunology
Relevant review or meta-analysis for the signal-disease area.
Intestinal Barrier Permeability in Allergic Diseases.
2022Nutrients
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and atopic dermatitis in children: a scoping review.
2022BMC pediatrics
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota in various childhood disorders: Implication and indications.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases.
2022Gut microbes
Relevant review or meta-analysis for the signal-disease area.
The Intestinal and Skin Microbiome in Patients with Atopic Dermatitis and Their Influence on the Course of the Disease: A Literature Review.
2023Healthcare (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Obesity and the microbiome in atopic dermatitis: Therapeutic implications for PPAR-γ agonists.
2023Frontiers in allergy
Relevant review or meta-analysis for the signal-disease area.
Relationship between Gut Microbiota and Allergies in Children: A Literature Review.
2023Nutrients
Relevant review or meta-analysis for the signal-disease area.
The Interaction between the Host Genome, Epigenome, and the Gut-Skin Axis Microbiome in Atopic Dermatitis.
2023International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Modulation of the Immune System Mechanisms using Probiotic Bacteria in Allergic Diseases: Focus on Allergic Retinitis and Food Allergies.
2024Recent advances in inflammation & allergy drug discovery
Relevant review or meta-analysis for the signal-disease area.
Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.
2024The Journal of investigative dermatology
Relevant review or meta-analysis for the signal-disease area.
Skin, gut, and lung barrier: Physiological interface and target of intervention for preventing and treating allergic diseases.
2024Allergy
Relevant review or meta-analysis for the signal-disease area.
Atopic dermatitis and food allergy: More than sensitization.
2024Mucosal immunology
Relevant review or meta-analysis for the signal-disease area.
Mapping the relationship between atopic dermatitis and gut microbiota: a bibliometric analysis, 2014-2023.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Transplant-Acquired Food Allergy in Children.
2024Nutrients
Relevant review or meta-analysis for the signal-disease area.
Unraveling the gut-skin axis in atopic dermatitis: exploiting insights for therapeutic strategies.
2024Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Gut Dysbiosis and Adult Atopic Dermatitis: A Systematic Review.
2024Journal of clinical medicine
Relevant review or meta-analysis for the signal-disease area.
The gut-skin axis: a bi-directional, microbiota-driven relationship with therapeutic potential.
2025Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Beyond the Skin: Exploring the Gut-Skin Axis in Chronic Spontaneous Urticaria and Other Inflammatory Skin Diseases.
2025Biomedicines
Relevant review or meta-analysis for the signal-disease area.
Gut-skin axis: Emerging insights for gastroenterologists-a narrative review.
2025World journal of gastrointestinal pathophysiology
Relevant review or meta-analysis for the signal-disease area.
[Asthma caused by food allergy].
1996La Revue de medecine interne
Relevant review or meta-analysis for the signal-disease area.