review_heavy
Review literature is very dense relative to primary central evidence.
supportedtopmoderate inflation risk
Fusobacterium nucleatum
inflammatory bowel disease
Fusobacterium nucleatum looks like a credible signal in inflammatory bowel disease, though some caution is still warranted.
Fusobacterium nucleatum shows a moderate evidence base in inflammatory bowel disease, with multiple central papers and additional supporting literature.
fusobacterium_nucleatum
Credibility score
70
Human translation
3/5
Reproducibility
5/5
Novelty
1/5
Actionability
3/5
Credibility 70Human translation 3/5Reproducibility 5/5Novelty 1/5Actionability 3/5
Why this scores the way it does
- moderate central evidence base
- dense review literature
- substantial preclinical support
Main caveats
- directionality and confounding still require curated review
Internal review flags
1 flagsPrimary central evidence
14 papersDog and human inflammatory bowel disease rely on overlapping yet distinct dysbiosis networks.
2016Nature microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Correlation of diet, microbiota and metabolite networks in inflammatory bowel disease.
2019Journal of digestive diseases
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fusobacteriumnucleatum Adheres to Clostridioides difficile via the RadD Adhesin to Enhance Biofilm Formation in Intestinal Mucus.
2021Gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota profile in patients with inflammatory bowel disease in Taiwan.
2021Journal of the Chinese Medical Association : JCMA
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota transplantation as a new treatment for canine inflammatory bowel disease.
2021Bioscience of microbiota, food and health
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Fecal microbiota profiling in irritable bowel syndrome and inflammatory bowel disease patients with irritable bowel syndrome-type symptoms.
2021BMC gastroenterology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Analysis of gut microbiome profiles in common marmosets (Callithrix jacchus) in health and intestinal disease.
2022Scientific reports
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Differences in the Intestinal Flora of Patients with Inflammatory Bowel Disease in Southwest China.
2022Indian journal of microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Dark-purple rice extract modulates gut microbiota composition in acetic acid- and indomethacin-induced inflammatory bowel disease in rats.
2023International microbiology : the official journal of the Spanish Society for Microbiology
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Microbial Disruptions in Inflammatory Bowel Disease: A Comparative Analysis.
2024International journal of general medicine
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
A Novel Microbial Dysbiosis Index and Intestinal Microbiota-Associated Markers as Tools of Precision Medicine in Inflammatory Bowel Disease Paediatric Patients.
2024International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
The physical biogeography of Fusobacterium nucleatum in health and disease.
2025mBio
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Investigating the Impact of Fusobacterium nucleatum on Oxidative Stress, Chemoresistance, and Inflammation in Inflammatory Bowel Disease and Colorectal Cancer: Rationale and Design of a Clinical Trial.
2025International journal of molecular sciences
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
First insights into microbial changes within an Inflammatory Bowel Disease Family Cohort study.
2025Gut microbes
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Supporting primary evidence
1 papersDo biofilms confer a pro-carcinogenic state?
2016Gut microbes
Human primary paper with plausible association relevance to the disease context.
Preclinical supporting evidence
10 papersPerturbed human sub-networks by Fusobacterium nucleatum candidate virulence proteins.
2017Microbiome
Disease-relevant preclinical or model-based paper useful as supporting evidence.
FadA-positive Fusobacterium nucleatum is prevalent in biopsy specimens of Iranian patients with colorectal cancer.
2020New microbes and new infections
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fusobacterium nucleatum exacerbates colitis by damaging epithelial barriers and inducing aberrant inflammation.
2020Journal of digestive diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Fusobacterium nucleatum impedes remission of colitis in a mouse model.
2021Bioscience, biotechnology, and biochemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The oral-gut axis: Salivary and fecal microbiome dysbiosis in patients with inflammatory bowel disease.
2022Frontiers in cellular and infection microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Composition of the colon microbiota in the individuals with inflammatory bowel disease and colon cancer.
2024Folia microbiologica
Disease-relevant preclinical or model-based paper useful as supporting evidence.
The Norepinephrine-QseC Axis Aggravates F. nucleatum-associated Colitis Through Interkingdom Signaling.
2024Inflammatory bowel diseases
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Gut microbial and metabolomics profiles reveal the potential mechanism of fecal microbiota transplantation in modulating the progression of colitis-associated colorectal cancer in mice.
2024Journal of translational medicine
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Addressing controversy in Fusobacterium nomenclature: what exactly does "F. nucleatum" refer to?
2025Gut microbes
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Disease-driven restructuring of the gut microbiome underlies inflammatory bowel disease dysbiosis.
2025Frontiers in microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
36 papersFusobacterium nucleatum: an emerging gut pathogen?
2011Gut microbes
Relevant review or meta-analysis for the signal-disease area.
Fusobacterium nucleatum: an emerging bug in colorectal tumorigenesis.
2015European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)
Relevant review or meta-analysis for the signal-disease area.
Fusobacterium nucleatum: a commensal-turned pathogen.
2015Current opinion in microbiology
Relevant review or meta-analysis for the signal-disease area.
Fusobacterium nucleatum, inflammation, and immunity: the fire within human gut.
2016Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
Relevant review or meta-analysis for the signal-disease area.
Impact of Klebsiella pneumoniae in lower gastrointestinal tract diseases.
2018Journal of digestive diseases
Relevant review or meta-analysis for the signal-disease area.
The Association between Inflammatory Bowel Disease and Periodontal Conditions: Is There a Common Bacterial Etiology?
2018Journal of the International Academy of Periodontology
Relevant review or meta-analysis for the signal-disease area.
Potential Use of Biotherapeutic Bacteria to Target Colorectal Cancer-Associated Taxa.
2020International journal of molecular sciences
Relevant review or meta-analysis for the signal-disease area.
Predictive values of colon microbiota in the treatment response to colorectal cancer.
2020Pharmacogenomics
Relevant review or meta-analysis for the signal-disease area.
New Insights into the Role of Oral Microbiota Dysbiosis in the Pathogenesis of Inflammatory Bowel Disease.
2022Digestive diseases and sciences
Relevant review or meta-analysis for the signal-disease area.
TLR4 signaling in the development of colitis-associated cancer and its possible interplay with microRNA-155.
2021Cell communication and signaling : CCS
Relevant review or meta-analysis for the signal-disease area.
Co-pathogens in Periodontitis and Inflammatory Bowel Disease.
2021Frontiers in medicine
Relevant review or meta-analysis for the signal-disease area.
Expanding the Colorectal Cancer Biomarkers Based on the Human Gut Phageome.
2021Microbiology spectrum
Relevant review or meta-analysis for the signal-disease area.
Bacterial Species Associated With Human Inflammatory Bowel Disease and Their Pathogenic Mechanisms.
2022Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Searching for a Consensus Among Inflammatory Bowel Disease Studies: A Systematic Meta-Analysis.
2023Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
Insight into the Relationship between Oral Microbiota and the Inflammatory Bowel Disease.
2022Microorganisms
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota, inflammatory bowel disease and colorectal cancer.
2022World journal of gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Fusobacterium nucleatum and its associated systemic diseases: epidemiologic studies and possible mechanisms.
2023Journal of oral microbiology
Relevant review or meta-analysis for the signal-disease area.
The Oral-Gut Axis: Periodontal Diseases and Gastrointestinal Disorders.
2023Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
The effect of the "Oral-Gut" axis on periodontitis in inflammatory bowel disease: A review of microbe and immune mechanism associations.
2023Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Periodontitis and progression of gastrointestinal cancer: current knowledge and future perspective.
2023Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Relevant review or meta-analysis for the signal-disease area.
Crosstalk between microbial biofilms in the gastrointestinal tract and chronic mucosa diseases.
2023Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Anaerobes in specific infectious and noninfectious diseases: new developments.
2023Anaerobe
Relevant review or meta-analysis for the signal-disease area.
Antibiotics for inflammatory bowel disease: Current status.
2024Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology
Relevant review or meta-analysis for the signal-disease area.
Periodontitis increases the risk of gastrointestinal dysfunction: an update on the plausible pathogenic molecular mechanisms.
2025Critical reviews in microbiology
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota mediated T cells regulation and autoimmune diseases.
2024Frontiers in microbiology
Relevant review or meta-analysis for the signal-disease area.
Inflammatory Bowel Disease and Colorectal Cancer: An Eternal Fire in a Beautiful Garden.
2024South Asian journal of cancer
Relevant review or meta-analysis for the signal-disease area.
Oral Fusobacterium nucleatum exacerbates ulcerative colitis via the oral-gut axis: mechanisms and therapeutic implications.
2025Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
From traditional to artificial intelligence-driven approaches: Revolutionizing personalized and precision nutrition in inflammatory bowel disease.
2025Clinical nutrition ESPEN
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota as a mediator of cancer development and management: From colitis to colitis-associated dysplasia and carcinoma.
2025Biochimica et biophysica acta. Reviews on cancer
Relevant review or meta-analysis for the signal-disease area.
A Systematic Review and Meta-Analysis of Animal Models on the Possible Link Between Periodontitis and Inflammatory Bowel Diseases.
2025Inflammatory bowel diseases
Relevant review or meta-analysis for the signal-disease area.
The Oral-Gut Microbiota Axis Across the Lifespan: New Insights on a Forgotten Interaction.
2025Nutrients
Relevant review or meta-analysis for the signal-disease area.
Fusobacterium nucleatum: ecology, pathogenesis and clinical implications.
2026Nature reviews. Microbiology
Relevant review or meta-analysis for the signal-disease area.
The Oral-Gut-Systemic Axis: Emerging Insights into Periodontitis, Microbiota Dysbiosis, and Systemic Disease Interplay.
2025Diagnostics (Basel, Switzerland)
Relevant review or meta-analysis for the signal-disease area.
Fusobacterium nucleatum: a transboundary pathogen in host-microbiota networks.
2025Gut pathogens
Relevant review or meta-analysis for the signal-disease area.
Gut microbiota and macrophage crosstalk: implications for colitis-associated colorectal cancer.
2026Frontiers in cellular and infection microbiology
Relevant review or meta-analysis for the signal-disease area.
Microbial mechanisms and therapeutic interventions in the periodontitis-inflammatory bowel disease axis: a comprehensive review.
2026Journal of oral microbiology
Relevant review or meta-analysis for the signal-disease area.