preclinical_heavy
Preclinical evidence exceeds central human evidence. Interpret translational relevance cautiously.
candidateweakhigh inflation risk
Flavonifractor plautii
inflammatory bowel disease
Flavonifractor plautii has meaningful literature visibility in inflammatory bowel disease, but the current evidence mix suggests a substantial risk of overclaiming.
Flavonifractor plautii has a broader but less central evidence footprint in inflammatory bowel disease, with support coming from indirect, review, or preclinical literature.
flavonifractor_plautii
Credibility score
14
Human translation
2/5
Reproducibility
2/5
Novelty
4/5
Actionability
1/5
Credibility 14Human translation 2/5Reproducibility 2/5Novelty 4/5Actionability 1/5
Why this scores the way it does
- limited structured evidence volume
Main caveats
- preclinical evidence outweighs human evidence
- limited central evidence
Internal review flags
1 flagsPrimary central evidence
4 papers[Correlation between Vitamin D Status and Gut Microbiota in Patients with Inflammatory Bowel Disease].
2020Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Gut Microbial Species and Endotypes Associate with Remission in Ulcerative Colitis Patients Treated with Anti-TNF or Anti-integrin Therapy.
2024Journal of Crohn's & colitis
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Predicting Risk of Post-Treatment Relapse in Patients with Inflammatory Bowel Disease Based on Intestinal Microbiota.
2025Journal of inflammation research
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Interaction between Chinese olive (Canarium album L.) polyphenols and gut microbiota: Potential implications for inflammatory bowel disease.
2026Journal of the science of food and agriculture
Direct disease-relevant human paper with strong clinical, biomarker, or mechanistic framing.
Preclinical supporting evidence
7 papersSoy hull dietary fiber alleviates inflammation in BALB/C mice by modulating the gut microbiota and suppressing the TLR-4/NF-κB signaling pathway.
2020Food & function
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Oral Administration of Flavonifractor plautii, a Bacteria Increased With Green Tea Consumption, Promotes Recovery From Acute Colitis in Mice via Suppression of IL-17.
2020Frontiers in nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Ecological and network analyses identify four microbial species with potential significance for the diagnosis/treatment of ulcerative colitis (UC).
2021BMC microbiology
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Echinococcus granulosus sensu stricto and antigen B may decrease inflammatory bowel disease through regulation of M1/2 polarization.
2022Parasites & vectors
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Intracellular Polysaccharides of Aspergillus cristatus from Fuzhuan Brick Tea Leverage the Gut Microbiota and Repair the Intestinal Barrier to Ameliorate DSS-Induced Colitis in Mice.
2023Journal of agricultural and food chemistry
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Regulation of gut microbiota and alleviation of DSS-induced colitis by vitexin.
2023European journal of nutrition
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Colonization of microbiota derived from Macaca fascicularis, Bama miniature pigs, beagle dogs, and C57BL/6J mice alleviates DSS-induced colitis in germ-free mice.
2024Microbiology spectrum
Disease-relevant preclinical or model-based paper useful as supporting evidence.
Review supporting evidence
1 papersFlavonifractor plautii bacteremia following bacterial translocation from the gut: A case report and literature review.
2025Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
Relevant review or meta-analysis for the signal-disease area.